Clinical Utility of Computer-Aided Diagnosis of Vertebral Fractures From Computed Tomography Images.

Osteoporotic vertebral compression fractures (VCFs) are a risk factor for morbidity and mortality, frequently asymptomatic and often present in computed tomography (CT) scans performed for unrelated conditions. Computer-aided diagnosis (CAD) of VCF from such images can potentially improve identification and treatment of osteoporosis. This single-blinded, single tertiary center study compared a CAD (Zebra Medical Vision®) to an adjudicated imaging specialist reevaluation using a retrospective consecutive sample of abdominal and thoracic CT scans (n = 2357) performed as part of routine care.

Validation of longitudinal DXA changes in body composition from pre- to mid-adolescence using MRI as reference.

Dual-energy X-ray absorptiometry (DXA) has been used extensively for bone mineral density and body composition assessments. Surprisingly, the role of DXA in monitoring changes in children's body composition, using direct imaging methods such as magnetic resonance imaging (MRI) as reference, is still yet to be validated. We aimed at validating the use of DXA in monitoring change in the thigh lean soft tissue mass (LSTM) and fat mass (FM) when compared with thigh skeletal muscle mass (SM) and FM, measured using MRI as the reference standard, from childhood to midadolescence.

Prediction of appendicular skeletal and fat mass in children: excellent concordance of dual-energy X-ray absorptiometry and magnetic resonance imaging.

Background: Body composition studies in children have great potential to help understand the aetiology and evolution of acute and chronic. diseases.

Aim: To validate appendicular lean soft tissue mass (LSTM) and fat mass (FM) measured using dual energy X-ray absorptiometry (DXA), with magnetic resonance imaging (MRI) as the reference standard, in healthy peri-pubertal adolescents.

Bone mineral density, body mass index and cigarette smoking among Iranian women: implications for prevention.

Background: While risk factors of osteoporosis in Western populations have been extensively documented, such a profile has not been well studied in Caucasians of non-European origin. This study was designed to estimate the modifiable distribution and determinants of bone mineral density (BMD) among Iranian women in Australia.

Methods: Ninety women aged 35 years and older completed a questionnaire on socio-demographic and lifestyle factors.

Reproducibility and concordance in quantitative ultrasound measurements between densitometers: a comparative study.

Although calcaneal quantitative ultrasound (QUS) is an independent predictor of osteoporotic fracture, its role in monitoring changes in bone status remains limited because of its relatively poor precision compared to the rate of bone loss. Recently, imaging QUS has been developed that can standardize the region of interest in the calcaneus with the potential of improving precision. We assessed the concordance and precision of an imaging QUS scanner (UBIS 5000) and a nonimaging scanner (LUNAR Achilles+) in 52 subjects aged between 27 and 79 yr.

Limited utility of clinical indices for the prediction of symptomatic fracture risk in postmenopausal women.

Bone mineral density (BMD) is the primary predictor of fracture, and is utilised in the definition of osteoporosis. Mass screening for osteoporosis is, however, currently not recommended. The primary objective of this study was to develop, validate and assess a simple, non-invasive scoring system to identify women at high risk of fracture.

The diagnostic role of dual femur bone density measurement in low-impact fractures.

A high correlation has been documented between the left and right femoral bone mineral densities in the normal population. This suggests that dual femur measurements are not justified in clinical practice. This study evaluated whether this premise holds for subjects who have lost bone mass and have sustained fractures with minimal trauma.