Ternary Complexes of BiI/CuI and SbI/CuI with Tetrahydrothiophene.

Reactions of BiI/CuI mixtures with tetrahydrothiophene (THT) in toluene produce 2-D sheet networks BiCuI(THT) ( = 2, 3, or 4), depending on reaction conditions. All three structures are based on BiI octahedra, which share pairs of (μ-I) with Cu(THT) units. BiCuI(THT) features Cu(μ-I) rhombs with close Cu···Cu interactions and is accompanied by formation of the very complex HBiCuI(THT).

HIF2α-Targeted RNAi Therapeutic Inhibits Clear Cell Renal Cell Carcinoma.

Targeted therapy against VEGF and mTOR pathways has been established as the standard-of-care for metastatic clear cell renal cell carcinoma (ccRCC); however, these treatments frequently fail and most patients become refractory requiring subsequent alternative therapeutic options. Therefore, development of innovative and effective treatments is imperative. About 80%-90% of ccRCC tumors express an inactive mutant form of the von Hippel-Lindau protein (pVHL), an E3 ubiquitin ligase that promotes target protein degradation.

Protease-triggered siRNA delivery vehicles.

The safe and efficacious delivery of membrane impermeable therapeutics requires cytoplasmic access without the toxicity of nonspecific cytoplasmic membrane lysis. We have developed a mechanism for control of cytoplasmic release which utilizes endogenous proteases as a trigger and results in functional delivery of small interfering RNA (siRNA). The delivery approach is based on reversible inhibition of membrane disruptive polymers with protease-sensitive substrates.