Effect of the tumor vascular-damaging agent, ZD6126, on the radioresponse of U87 glioblastoma.

Purpose: The effect of ZD6126 on tumor oxygen tension and tumor growth delay in combination with ionizing radiation was examined in the human U87 glioblastoma tumor model. Resistance to ZD6126 treatment was investigated with the nitric oxide synthase inhibitor, l-N(G)-nitroarginine methyl ester (hydrochloride; l-NAME/active form, l-NNA).

Methods: U87 human xenografts were grown in athymic nude mice.