Publications by authors named "Nicaise A N'guessan"
Article Synopsis
- A study by the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) in Côte d'Ivoire evaluated the effectiveness of school-based treatments (SBT) with praziquantel on controlling schistosomiasis mansoni among children.
- Initial infection levels showed a prevalence of 22.1%, which significantly dropped to 12.8% in the follow-up one year later, indicating the treatment's effectiveness while some schools showed a rise in infection despite sufficient treatment coverage.
- The overall findings suggest that while SBT led to a reduction in schistosomiasis prevalence, challenges remain in certain schools, highlighting the need for ongoing monitoring and potentially adjusted intervention strategies.
Article Synopsis
- A baseline survey was conducted in 75 schools in western Côte d'Ivoire to assess the prevalence of Schistosoma mansoni before a 4-year intervention trial using praziquantel.
- The study involved nearly 12,000 children, revealing a prevalence rate of 5.4% in first graders and 22.1% in older children, highlighting significant differences based on age.
- Key factors such as open defecation practices were noted, as they may influence transmission dynamics, providing essential context for evaluating treatment impacts over the trial period.
Article Synopsis
- Schistosomiasis is a parasitic disease prevalent in tropical regions, especially in Africa, where around 230 million people need preventive treatment with praziquantel; a significant study is being conducted in Côte d'Ivoire to assess the effectiveness of different treatment strategies.
- A large-scale eligibility survey screened over 12,000 children for Schistosoma mansoni in western Côte d'Ivoire, leading to the selection of schools with varying infection rates for a multi-treatment trial approved by ethics committees in Basel and Côte d'Ivoire.
- The study aims to track changes in infection rates and intensity over five years while collecting data on treatment costs and various environmental and political factors to understand their impact on schistosomiasis control effectiveness.
The Taabo Health and Demographic Surveillance System (HDSS) is located in south-central Côte d'Ivoire, approximately 150 km north-west of Abidjan. The Taabo HDSS started surveillance activities in early 2009 and the man-made Lake Taabo is a key eco-epidemiological feature. Since inception, there has been a strong interest in research and integrated control of water-associated diseases such as schistosomiasis and malaria.
View Article and Find Full Text PDFBackground: Treatment and morbidity control of schistosomiasis relies on a single drug, praziquantel. Hence, there is a pressing need to develop additional therapeutics against schistosomiasis. The antimalarial drug mefloquine shows antischistosomal activity in animal models and clinical trials, which calls for further investigations.
View Article and Find Full Text PDFSchistosomiasis control efforts mainly target school-aged children. We studied the epidemiology of schistosomiasis in two high-risk communities in south Côte d'Ivoire, placing particular emphasis on pre-school-aged children. We used a suite of diagnostic techniques, including Kato-Katz, urine filtration, reagent strips, and urine circulating cathodic antigen cassettes.
View Article and Find Full Text PDFBackground: The Kato-Katz technique is widely used for the diagnosis of Schistosoma mansoni, but shows low sensitivity in light-intensity infections. We assessed the accuracy of a commercially available point-of-care circulating cathodic antigen (POC-CCA) cassette test for the diagnosis of S. mansoni in preschool-aged children before and after praziquantel administration.
View Article and Find Full Text PDFBackground: Promising results have been reported for a urine circulating cathodic antigen (CCA) test for the diagnosis of Schistosoma mansoni. We assessed the accuracy of a commercially available CCA cassette test (designated CCA-A) and an experimental formulation (CCA-B) for S. mansoni diagnosis.
View Article and Find Full Text PDFBackground: Morbidity control of schistosomiasis relies on a single drug, praziquantel. The antimalarial drug mefloquine possesses interesting antischistosomal properties, yet no clinical studies have been performed.
Methods: We conducted a randomized, exploratory open-label trial to assess the efficacy and safety of mefloquine (25 mg/kg), artesunate (3 doses of 4 mg/kg), mefloquine-artesunate (3 doses of 100 mg artesunate plus 250 mg mefloquine), and praziquantel (40 mg/kg) against Schistosoma haematobium.
Background: New efforts are being made to improve understanding of the epidemiology of the helminths and intensifying the control efforts against these parasites. In contrast, relatively few studies are being carried out in this direction for the intestinal protozoa. To contribute to a better comprehension of the epidemiology of the intestinal protozoa, prevalence, and spatial distribution of Entamoeba histolytica/dispar and Giardia lamblia, and their association with drinking water supplies, were determined in the Agboville department in southeast Côte d'Ivoire.
View Article and Find Full Text PDFTwo cross-sectional surveys were carried out in rural Côte d'Ivoire, the first in 5 primary schools in the Lake Taabo area, and the second in the primary school of Azaguié-Institute de Recherche sur les Fruits et Agrumes. Overall, 251 school children were screened for Strongyloides stercoralis by using either the Baermann method, or the Koga agar plate method, or both techniques. The prevalence of S.
View Article and Find Full Text PDFArtemether is an efficacious antimalarial drug that also displays antischistosomal properties. Laboratory studies have found that artemether curtails the development of adult worms of Schistosoma japonicum, S. mansoni and S.
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