Relationship of Biochemical and Hematological Markers With Alcohol Withdrawal Severity.

Background Alcohol withdrawal severity is widely assessed and objectified using the Clinical Institute Withdrawal Assessment for Alcohol revised (CIWA-Ar) scale. However, the subjective nature of this scale has led to several studies that scrutinized the relationship of various blood parameters to assess withdrawal severity. The aim of this study was to analyze the relationship of various laboratory biomarkers with the severity of alcohol withdrawal.

The Effect of the Charlson Comorbidity Index On In-Hospital Complications, Hospital Length of Stay, Mortality, and Readmissions Among Patients Hospitalized for Acute Stroke.

Aim A notable number of people who develop stroke have comorbid medical conditions. The aim of this study is to evaluate the use of the Charlson Comorbidity Index (CCI) to predict in-hospital complications, mortality, length of stay, and readmission rates in stroke patients. Method It is a retrospective study that analyzed patients who were admitted for stroke in a six-month time duration.

Increasing venous thromboembolism risk assessment through a whole hospital-based intervention: a pre-post service evaluation to demonstrate quality improvement.

Venous thromboembolism (VTE) is a primary cause of morbidity and mortality in hospitalized patients. VTE risk assessment is a crucial part of the VTE prevention guideline. However, VTE risk assessment was not consistently undertaken for admitted patients.

Duration and aetiology of extended hospitalization among COVID-19 patients in United Arab Emirates.

Background: A retrospective review of the early stages of the COVID-19 pandemic in 2020 and the challenges faced by hospitals is essential in the post-pandemic era of 2022.

Aim: To identify the reasons for prolonged hospitalization after recovery for COVID-19 patients in the United Arab Emirates.

Methods: This was a retrospective observational study of 150 (18.

Efficacy and safety of direct oral anticoagulants with and without Aspirin: A systematic review and Meta-analysis.

Background: Various anticoagulant therapies are prescribed to patients under physicians' discretion and recently Direct Oral Anticoagulants(DOAC) have been under trials to evaluate their safety and efficacy. In addition to this, the regimen of DOACs and Aspirin is of keen interest as researchers continue to find an optimal regimen to treat blood clots in patients. This study is a systematic review and -analysis of randomized controlled trials and observational studies that asses the safety and efficacy of DOAC with and without Aspirin.

Physicians' perceptions and preferences for implementing venous thromboembolism (VTE) clinical practice guidelines: a qualitative study using the Theoretical Domains Framework (TDF).

Background: Venous thromboembolism is a primary cause of morbidity and mortality in hospitalised patients. Clinical practice guidelines were developed to prevent venous thromboembolism events. This study adopted the Theoretical Domains Framework to explore the beliefs and perceptions of physicians adoption of clinical practice guidelines for the uptake of venous thromboembolism prevention guidelines.

Complement-mediated autoimmune haemolytic anaemia as an initial presentation of Legionnaires' disease.

A 42-year-old diabetic man presented to the hospital with severe sepsis and multiorgan dysfunction. A probable respiratory source of sepsis was suspected because of suggestive clinical and radiological findings. He was critically ill and was therefore admitted to intensive care for further management including ventilatory support and renal replacement therapy.

Blood pressure control measured as "time in range" during initial 24 h for inpatients with spontaneous nontraumatic intracerebral haemorrhage.

Background And Purpose: Blood pressure (BP) control is an integral part in the management of spontaneous nontraumatic intracerebral haemorrhage. The aim of this study is to propose a novel concept of blood pressure control measured as 'Time in Range'(TiR) and assess its relationship to neurological deterioration.

Method: Retrospective study of 120 patients with Intracerebral haemorrhage who were admitted within 6 h of the symptom onset.

COVID-19-associated leukocytoclastic vasculitis leading to gangrene and amputation.

A 41-year-old male with type 2 diabetes mellitus (T2DM) presented with complaints of recent onset limb weakness, diffuse body rash and fever. Computerized Tomography (CT) scan of the brain did not reveal a stroke but laboratory investigations of the patient portrayed multi-systemic involvement. Naso-pharyngeal swab for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was taken which resulted as positive.

Rapidly worsening pneumonia in a middle-aged woman: a rare diagnosis and a crucial management decision.

A 54-year-old Indian female presented to the hospital with a 4-day history of fever, shortness of breath and blood-streaked sputum. Chest radiograph showed consolidation and she was admitted as a case of bilateral bronchopneumonia. She was started on broad-spectrum antibiotics and antivirals but she continued to deteriorate clinically with increasing oxygen requirement and worsening lung infiltrates.

Prediction of risk of adverse events related to percutaneous endoscopic gastrostomy: a retrospective study.

Background: Percutaneous endoscopic gastrostomy (PEG) is a popular method for long-term enteral feeding. Our aim was to determine potential risk factors for adverse events related to PEG, as well as consequent prolonged hospitalization.

Methods: Data were retrospectively collected from the admission records of a tertiary center between July 2015 and June 2018.

Rhabdomyolysis: a rare adverse effect of levetiracetam.

A 62-year-old previously healthy male was admitted with new onset generalised tonic-clonic seizures. Treatment was initiated with the antiepileptic levetiracetam and he had no further episodes of seizures. Creatine kinase (CPK) level was 1812 IU/L 12-hour postadmission.

An extraordinary case of recurrent stroke, disseminated thrombosis and endocarditis.

A 43-year-old woman with no known cardiovascular risk factors was admitted with a second episode of ischaemic stroke. She was not a known case of connective tissue disease like systemic lupus erythematosus or antiphospholipid syndrome (APS). During the current episode, she was found to have markedly deranged coagulation parameters and laboratory evidence of microangiopathic haemolysis, but no evidence of sepsis or active bleeding.

Ackerman syndrome: a rare cause of arthritis with dermatitis.

We present a case of a middle-aged woman who presented with acute onset of non-erosive oligoarthritis and cutaneous lesions. Her laboratory work up revealed mild anaemia with positive antinuclear antibody. Her skin biopsy confirmed the presence of interstitial granulomatous dermatitis.

A young patient with recurrent respiratory tract infection and anasarca.

A young man with a history of recurrent respiratory tract infections for the past 8 years presented with generalised anasarca. He was found to have advanced renal disease (stage 4) and a profound proteinuria of 82.9 g/day.

Vitamin D deficiency in fibromyalgia.

Objective: To check the Vitamin D levels in patients diagnosed as fibromyagia in our population.

Methods: Study was done at Medical OPD of Civil Hospital Karachi, from January to March 2009. Female patients diagnosed as Fibromyalgia according to American College of Rheumatology (ACR) criteria and exclusion of systemic illness on examination, and normal reports of blood CP, ESR, serum calcium, phosphate and Alkaline Phosphatase, were asked to get Vitamin D levels in their serum.

Liver histology in hepatitis C virus positive patients with normal and elevated alanine amino transferase levels.

Objective: To compare liver histology in HCV RNA positive patients with normal and elevated Alanine Aminotransferase Level (AST).

Methods: This Cohort (prospective) study was conducted at Civil Hospital Karachi from Jan 2007 to July 2007. Forty patients with positive HCV RNA were included.

Frequency, characteristics and risk factors of carotid artery stenosis in ischaemic stroke patients at Civil Hospital Karachi.

Objective: To determine the frequency and characteristics of carotid artery stenosis in acute ischaemic stroke patients and to assess the significance of common risk factors for carotid stenosis in these patients.

Method: One hundred consecutive patients admitted with acute ischaemic stroke were included in the study. The relevant history, physical examination and laboratory investigations were done as per the Performa.

Acute acalculous cholecystitis in dengue fever.

Objective: To investigate the frequency, clinical features, management and outcome of acute acalculous cholecystitis in dengue fever patients.

Methods: Forty patients were admitted with the diagnosis of dengue fever, according to the clinical manifestations and laboratory investigations. The diagnosis of dengue fever was confirmed by a positive IgM antibody test result for a late or convalescent phase blood specimen.

Three consecutive audits to achieve acceptable colonoscopy completion rates.

Objective: To compare the acceptable colonoscopy completion rates in three successive audits, identifying the reasons for failure of completion and rectifying them to improve the performance at our endoscopy unit.

Methods: Study was conducted at Endoscopy unit of Medical Unit One Civil Hospital Karachi. The first audit was conducted retrospectively on the colonoscopy results, done from November 2004 to November 2005.

Platelet count/splenic size ratio: a parameter to predict the presence of esophageal varices in cirrhotics.

Objective: To evaluate platelet count/ splenic size ratio as a non-invasive parameter to predict the presence and absence of esophageal varices in patients with cirrhosis of liver.

Design: An observational, cross- sectional study.

Place And Duration Of Study: The medical units of the Civil Hospital, Karachi, between October 2003 and October 2004.