Publications by authors named "Nianyu Jiang"
We report a low-cost, portable biosensor composed of an aptamer-functionalized nanoporous anodic aluminum oxide (NAAO) membrane and a commercial microcontroller chip-based impedance reader suitable for electrochemical impedance spectroscopy (EIS)-based sensing. The biosensor consists of two chambers separated by an aptamer-functionalized NAAO membrane, and the impedance reader is utilized to monitor transmembrane impedance changes. The biosensor is utilized to detect amodiaquine molecules using an amodiaquine-binding aptamer (OR7)-functionalized membrane.
View Article and Find Full Text PDFThe Ebola virus glycoprotein (GP) gene templates several mRNAs that produce either the virion-associated transmembrane protein or one of two secreted glycoproteins. Soluble glycoprotein (sGP) is the predominant product. GP1 and sGP share an amino terminal sequence of 295 amino acids but differ in quaternary structure, with GP1 being a heterohexamer with GP2 and sGP a homodimer.
View Article and Find Full Text PDFArticle Synopsis
- Researchers developed a biosensor using NK-lysin peptide-functionalized nanoporous anodized aluminum oxide (NAAO) to detect bacterial endotoxin, showing that NK-lysin peptides have antimicrobial properties.* -
- The study confirmed its effectiveness against both Gram-negative and Gram-positive bacteria and demonstrated the ability of the biosensor to detect lipopolysaccharides (LPS) at low concentrations.* -
- The results indicated that the specific interaction between NK2A and LPS was crucial for detection, making this biosensor a promising tool for rapid and sensitive identification of bacterial toxins without labels.*