Publications by authors named "Nianxuan Wu"

As the important barrier of intraocular tissue, cornea is easy to suffer various kinds of injuries. Among them, acute alkali burn is a thorny ophthalmic emergency event, which can lead to corneal persistent epithelial defects, ulcers, and even perforation. Ferroptosis, a mode of regulatory cell death, has been found to play a key role in the process of corneal alkali burn, of which lipid peroxidation and intracellular iron levels are considered to be the possible therapeutic targets.

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Persistent corneal epithelial defects (PED) can lead to irreversible blindness, seriously affecting the social function and life quality of these patients. When it comes to refractory PED, such as limbal stem cell deficiency (LSCD), that does not respond to standard managements, stem cell therapy is an ideal method. Oral mucosal epithelium (OME) abundant with stem cells within the base, is a promising autologous biomaterial, with much resemblance to corneal epithelial structures.

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Eyelid plays a vital role in protecting the eye from injury or infection. Inflammation related eyelid diseases, such as blepharitis, are the most common ocular disorders that affect human's vision and quality of life. Due to the physiological barriers and anatomical structures of the eye, the bioavailability of topical administrated therapeutics is typically less than 5%.

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Purpose: This study aimed to investigate the therapeutic effects and underlying mechanisms of locally delivered regulatory T cells (Tregs) on acute corneal wound healing after alkali burn.

Methods: After corneal alkali burn, the mice were injected subconjunctivally with regulatory T cells (Tregs) isolated from syngeneic mice. The wound healing process was monitored by clinical manifestation, flow cytometry, and enzyme-linked immunosorbent assay (ELISA).

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Conjunctival restoration is indispensable to help maintain the ocular surface microenvironment by secreting lubricative mucins. However, conventional amniotic membrane transplantation therapy has many limitations in its application due to risks involved with disease transmission and alloreactivity. As decellularized tissues have been frequently used for tissue engineering and adipose mesenchymal stem cells (ADMSCs) have been acknowledged for their low immunogenicity, we fabricated a decellularized matrix of adipose-derived mesenchymal stromal cells (DMA) to study the therapeutic potential of DMA in healing conjunctival defects.

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Article Synopsis
  • Severe conjunctival diseases lead to scarring that restricts eye movement and vision, making reconstruction difficult due to limited methods for enriching stem cells.
  • The study found that p75 positive conjunctival epithelial cells (CjECs) are primarily found in the basal layer of the conjunctiva, expressing high levels of stem cell markers and showing strong growth potential for conjunctival reconstruction.
  • Adding nerve growth factor (NGF) enhances the differentiation of CjECs through a specific signaling pathway, while its precursor, proNGF, inhibits this process, highlighting the potential of p75++ CjECs in eye recovery therapies.
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Article Synopsis
  • This article corrects errors in previously published research related to bioengineering.
  • The DOI reflects the unique identifier for the original article, ensuring proper attribution.
  • The correction highlights the importance of accuracy in scientific publications for reliability.
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Article Synopsis
  • Conjunctival fibrosis occurs due to injury or inflammation, leading to extracellular matrix buildup that can hinder glaucoma surgery effectiveness.
  • The study found that autophagy plays a crucial role in managing this fibrosis, specifically induced by the protein TGF-β1, and can be influenced by substances like rapamycin and trehalose.
  • Trehalose was shown to reduce fibrosis by activating autophagy, offering potential new avenues for treating conjunctival fibrosis in clinical settings.
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Tarsal plate regeneration has always been a challenge in the treatment of eyelid defects. The commonly used clinical treatments such as hard palate mucosa grafts cannot achieve satisfactory repair effects. Tissue engineering has been considered as a promising technology.

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