Publications by authors named "Nian-Jing Rao"
Article Synopsis
- - The study investigated how zoledronic acid (ZA) impacts blood vessel structure in jaw and long bones using a rat model, with 24 female rats receiving either ZA or saline for 4 weeks.
- - Following surgical procedures, including tooth extractions and bone defects, the rats continued receiving their respective treatments until they were sacrificed at different intervals.
- - Results indicated that while ZA-treated rats showed a trend toward reduced blood vessel density and numbers, the differences were not statistically significant, suggesting that ZA may suppress new blood vessel formation but this does not significantly contribute to conditions like MRONJ (medication-related osteonecrosis of the jaw).
This study is to investigate the effect of bisphosphonates on the osseointegration of dental implants in a rabbit model. Twenty female New Zealand White rabbits were equally assigned into control and experiment groups which received saline or zoledronic acid treatment 4 weeks prior to surgery. Titanium dental implant was placed on the calvarial bone.
View Article and Find Full Text PDFBisphosphonates (BPs) have been extensively used for management of bone diseases with pathologically high resorption. Despite the great clinical benefits, a severe complication known as medication-related osteonecrosis of the jaw (MRONJ) has been reported. It is found that most of the reported MRONJ cases were limited in the jawbones/craniofacial bones instead of long bones.
View Article and Find Full Text PDFObjectives: This study aimed to assess the effect of zoledronic acid on an immunocompromised mice model with periapical disease.
Materials And Methods: Thirty C57BL/6N mice were randomly divided into three groups ( = 10). All animals were subjected to bilateral ovariectomy (OVX) and then treated with saline (Veh), zoledronic acid (ZA), or concomitant zoledronic acid and dexamethasone (ZA/Dx) for 12 weeks.
Objective: The present study aimed to investigate the role of periapical diseases in inducing medication-related osteonecrosis of the jaws (MRONJ) using an ovariectomized (OVX) mice model.
Materials And Methods: Twenty C57BL/6N female mice were randomly assigned to two groups. All mice were subjected to bilateral ovariectomy and then treated with oncologic dose of zoledronic acid (ZA) or vehicle for twelve weeks.
Objectives: The compromised capacity of bone healing in osteoporotic population renders a serious concern of patients and clinicians. This study aimed to investigate the influence of G-CSF on bone reconstruction using an osteoporotic animal model.
Materials And Methods: Sixty skeletal mature female Spraque-Dawley rats underwent bilateral ovariectomy (OVX) and were assigned into three groups (n = 20).
Background: Bone regeneration approaches that mimic the natural processes of bone repair have generated significant attention. We hypothesized that early delivery of an angiogenic factor combined with sustained exposure to an osteogenic factor would recapitulate the critical aspects of natural bone repair.
Materials And Methods: Basic fibroblast growth factor (bFGF) and sonic hedgehog (Shh) were constructed to the recombinant adeno-associated virus, respectively (rAAV2-tet-off-bFGF and rAAV2-Shh).