Publications by authors named "Nian Sheng"
Article Synopsis
- - Endothelial cell dysfunction and vascular leakage are key issues in blood stasis syndrome (BSS), prompting research into treatments that can restore vascular integrity.
- - A novel acidic polysaccharide (TPP-4) from Typhae Pollen was isolated and characterized using advanced techniques like spectroscopy and chromatography, revealing its structure as a heteropolysaccharide.
- - TPP-4 demonstrated significant potential in improving vascular integrity in both lab (HUVECs) and live models (zebrafish), acting through the VEGFA/PI3K/mTOR signaling pathway and impacting lipid metabolism, particularly in cases of inflammation.
Ethnopharmacological Relevance: Shixiao San (SXS) is a traditional Chinese formula that has been widely used in clinical practice to treat blood stasis syndromes, such as hyperlipidemia, atherosclerotic, thrombosis and coronary heart disease. However, the effectiveness and mechanism of SXS have not been studied in detail yet.
Aim Of The Study: Current study aimed to identify the compounds in SXS, evaluate the formula efficacies using network pharmacology, molecular docking, and verify the pharmacological effects by in vivo and in vitro experiments.
The ongoing corona virus disease 2019 (COVID-19) pandemic, caused by SARS-CoV-2 infection, has resulted in hundreds of thousands of deaths. Cellular entry of SARS-CoV-2, which is mediated by the viral spike protein and ACE2 receptor, is an essential target for the development of vaccines, therapeutic antibodies, and drugs. Using a mammalian cell expression system, a genetically engineered sensor of fluorescent protein (Gamillus)-fused SARS-CoV-2 spike trimer (STG) to probe the viral entry process is developed.
View Article and Find Full Text PDFHepatitis B e antigen (HBeAg) is a widely used marker both for chronic hepatitis B (CHB) clinical management and HBV-related basic research. However, due to its high amino acid sequence homology to hepatitis B core antigen (HBcAg), most of available anti-HBe antibodies are cross-reactive with HBcAg resulting in high interference against accurate measurement of the status and level of HBeAg. In the study, we generated several monoclonal antibodies (mAbs) targeting various epitopes on HBeAg and HBcAg.
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