Transcriptome reprogramming of Epstein-Barr virus infected epithelial and B cells reveals distinct host-virus interaction profiles.

Epstein-Barr virus (EBV) is an opportunistic pathogen that can manifest itself as a potential contributor to human diseases years after primary infection, specifically in lymphoid and epithelial cell malignancies in immune-competent and immune-compromised hosts. The virus shuttles between B cells and epithelial cells during its infection cycle, facilitating its persistence and transmission in humans. While EBV efficiently infects and transforms B-lymphocytes, epithelial cells are not as susceptible to transformation in vitro.

Water Quality Prediction Based on Multi-Task Learning.

Water pollution seriously endangers people's lives and restricts the sustainable development of the economy. Water quality prediction is essential for early warning and prevention of water pollution. However, the nonlinear characteristics of water quality data make it challenging to accurately predicted by traditional methods.

Coupling biostimulation and phytoremediation for the restoration of petroleum hydrocarbon-contaminated soil.

Total petroleum hydrocarbons (TPH) continue to be among the most common pollutants in soil worldwide. Bioremediation and phytoremediation have become sustainable ways of dealing with TPH contamination and biostimulation-assisted phytoremediation is considered as a potential approach for the treatment of pollutants. In this study, the response surface was used to optimize the single-factor biological stimulation experiment of moisture content, leavening agent content and compound fertilizer content and got the best experimental plan of biological stimulation.

Research Progress of Thermosensitive Hydrogel in Tumor Therapeutic.

Compared with traditional tumor therapy strategies, hydrogel as a drug reservoir system can realize on-demand drug release and deep tissue penetration ability. It also exhibits great tumor-site retention to enhance the permeability and retention effect of tumor treatment. This can significantly overcome the drug's resistance and severe side effects.

Antiviral Properties of Nanoparticles on Herpes Simplex Virus Type I and .

Herpes simplex virus type 1 (HSV-1), an enveloped DNA virus, plays a key role in varieties of diseases including recurrent cold sores, keratoconjunctivitis, genital herpes and encephalitis in humans. Great efforts have been made in developing more effective and less side-effects anti-herpes simplex virus agents, including traditional Chinese herbal medicines. In the present study, we evaluated the antiviral efficacy of nanoparticles against HSV-1 and .

Assessment of a new arbidol derivative against herpes simplex virus II in human cervical epithelial cells and in BALB/c mice.

As one of the highly contagious forms, herpes simplex virus type 2 (HSV-2) commonly caused severe genital diseases and closely referred to the HIV infection. The lack of effective vaccines and drug-resistance proclaimed the preoccupation for alternative antiviral agents against HSV-2. Molecules bearing indole nucleus presented diverse biological properties involving antiviral and anti-inflammatory activities.

Antiviral activity of arbidol hydrochloride against herpes simplex virus I in vitro and in vivo.

Herpes simplex virus type 1 (HSV-1) causes significant human diseases ranging from skin lesions to encephalitis, especially in neonates and immunocompromised hosts. The discovery of novel anti-HSV-1 drugs with low toxicity is required for public health. Arbidol hydrochloride (ARB) is an indole derivative molecule with broad-spectrum antiviral activity.

Myricetin Prevents Alveolar Bone Loss in an Experimental Ovariectomized Mouse Model of Periodontitis.

Periodontitis is a common chronic inflammatory disease, which leads to alveolar bone resorption. Healthy and functional alveolar bone, which can support the teeth and enable their movement, is very important for orthodontic treatment. Myricetin inhibited osteoclastogenesis by suppressing the expression of some genes, signaling pathways, and cytokines.

Specific interference shRNA-expressing plasmids inhibit Hantaan virus infection in vitro and in vivo.

Aim: To investigate the antiviral effects of vectors expressing specific short hairpin RNAs (shRNAs) against Hantaan virus (HTNV) infection in vitro and in vivo.

Methods: Based on the effects of 4 shRNAs targeting different regions of HTNV genomic RNA on viral replication, the most effective RNA interference fragments of the S and M genes were constructed in pSilencer-3.0-H1 vectors, and designated pSilencer-S and pSilencer-M, respectively.

Antiviral effect of emodin from Rheum palmatum against coxsakievirus B5 and human respiratory syncytial virus in vitro.

Viral infections are the major causes of morbidity and mortality in elderly people and young children throughout the world. The most common pathogens include coxsackie virus (CV) and respiratory syncytial virus (RSV). However, no antiviral agents with low toxicity and drug resistance are currently available in clinic therapy.

[Efficacy of routinely used patterns for schistosomiasis diagnosis in lake and marshland regions].

Objective: To evaluate the efficacy of routinely used pattern for schistosomiasis diagnosis in lake and marshland regions.

Methods: A historically heavy endemic village of schistosomiasis named Jinggan Village from Jiangling County was selected for field survey. The residents aged 6-65 years were screened by indirect hemagglutination assay (IHA) and dipstick dye immunoassay (DDIA) in parallel.

[Construction and operation of network laboratory for schistosomiasis diagnosis in Jianglin County].

Objective: To build a high quality diagnosis system for schistosomiasis surveillance in the situation of low infection in Jianglin County.

Methods: The network laboratory for schistosomiasis diagnosis was built according to the national criteria in Jianglin County in 2012.

Results: The network laboratory for schistosomiasis diagnosis was established successfully and the operation was quiet well.

[Effect of Parasep® feces centrifuge tube method on detecting schistosome eggs].

Objective: To evaluate the effect of the Parasep® feces centrifuge tube method on detecting schistosome eggs.

Methods: A total of 803 residents aged from 6-65 years were selected in 2 schistosomiasis endemic villages, Jiangling County, Hubei Province, and their stool samples were collected and detected parallelly by the Kato-Katz technique, nylon silk egg hatching method, and Parasep® feces centrifuge tube method at the same time.

Results: Among the 803 people, 15 cases were found of schistosome egg positive, and the positive rate was 1.

[Surveillance of endemic situation of schistosomiasis in a national surveillance site in Jiangling County from 2005 to 2011].

Objective: To understand the dynamics of schistosomiasis japonica in a national surveillance site in Jiangling County, Hubei Province, China, so as to provide the evidence for formulating the intervention strategy of schistosomiasis control in the whole county.

Methods: The surveillance was performed in the surveillance village according to The National Surveillance Scheme of Schistosomiasis japonica, and the results were analyzed statistically from 2005 to 2011.

Results: The schistosome infection rates in residents and cattle decreased from 1.