Identification of candidate genes associated with resistance to aflatoxin production in peanut through genetic mapping and transcriptome analysis.

Two major QTLs qAftA07and qAftB06.2 for peanut aflatoxin production resistance were identified and candidate genes for them were predicted. Peanut (Arachis hypogaea L.

Fluorine-modified passivator for efficient vacuum-deposited pure-red perovskite light-emitting diodes.

Vacuum-deposited perovskite light-emitting diodes (PeLEDs) have demonstrated significant potential for high-color-gamut active-matrix displays. Despite the rapid advance of green PeLEDs, red ones remain a considerable challenge because of the inferior photophysical properties of vacuum-deposited red-light-emitting materials. Here, a rationally designed fluorine-modified phosphine oxide additive was introduced to in-situ passivate vacuum-deposited perovskites.

MTMU: Multi-domain Transformation based Mamba-UNet designed for unruptured intracranial aneurysm segmentation.

The management of Unruptured Intracranial aneurysm (UIA) depends on the shape parameters assessment of lesions, which requires target segmentation. However, the segmentation of UIA is a challenging task due to the small volume of the lesions and the indistinct boundary between the lesion and the parent arteries. To relieve these issues, this article proposes a multi-domain transformation-based Mamba-UNet (MTMU) for UIA segmentation.

Enteric GABAergic neuron-derived γ-aminobutyric acid initiates expression of Igfbp7 to sustain ILC3 homeostasis.

Neuronal signals have emerged as critical factors that regulate group 3 innate lymphoid cell (ILC3) response and tissue homeostasis, but the molecular mechanisms underlying this regulation remain largely elusive. Here, we identified that the enteric GABAergic neuron-derived neurotransmitter γ-aminobutyric acid (GABA) inhibited proliferation and IL-17A production in ILC3s in a manner dependent on the GABA receptors Gabbr1 and Gabbr2. Conditional deletion of Gabbr1 or ablation of GABAergic neurons caused increased IL-17A production and aggravated colitis.

Prediction of pathological response to neoadjuvant immunochemotherapy with baseline and post-treatment F-FDG PET imaging biomarkers in patients with locally advanced gastric cancer.

Background: Neoadjuvant immunochemotherapy (NICT) has shown promising therapeutic benefits in patients with locally advanced gastric cancer (LAGC). Our study aimed to predict the pathological response to NICT in LAGC before surgery by correlating the metabolic parameters of baseline and post-treatment F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) of the primary lesion with the pathological response following radical surgery.

Methods: Thirty-six LAGC patients who received three cycles of NICT (combination of sintilimab and CapeOx), followed by radical surgery, were included in this study.

[Clinical Analysis of Listeriosis in Treatment of Multiple Myeloma with Novel Agents].

Objective: To analyze the clinical characteristics and outcomes of multiple myeloma (MM) patients infected with (LM) in novel agent era, so as to improve clinicians' understanding.

Methods: Clinical data of 4 MM patients infected with LM in Beijing Chao-yang Hospital from October 2018 to October 2022 was analyzed retrospectively.

Results: The average age of the 4 patients was (57.

Lithium Levels in Umbilical Cord Blood from Two Cities in China: Indicating Unidentified Sources of Human Exposure.

As lithium demand continues to grow, increasing environmental lithium concentrations pose potential health risks to sensitive populations, particularly pregnant women and fetuses. However, data on fetal lithium exposure and umbilical cord blood lithium concentrations in nonpolluted regions remain scarce. To address this gap, we monitored lithium concentrations in maternal and umbilical cord blood in Beijing and Changsha, and analyzed exposure sources using a one-compartment model.

Multi-sequence MRI-based nomogram for prediction of human epidermal growth factor receptor 2 expression in breast cancer.

Objective: To develop a nomogram based on multi-sequence MRI (msMRI) radiomics features and imaging characteristics for predicting human epidermal growth factor receptor 2 (HER2) expression in breast cancer (BC).

Methods: 206 women diagnosed with invasive BC were retrospectively enrolled and randomly divided into a training set (n = 144) and a validation set (n = 62) at the ratio of 7 : 3. Tumor segmentation and feature extraction were performed on dynamic contrast-enhanced (DCE) MRI, T2-weighted imaging (T2WI), and apparent diffusion coefficient (ADC) map.

Pulmonary mucinous adenocarcinoma: A case report and literature review.

Rationale: Pulmonary mucinous adenocarcinoma (PMA) is a rare subtype of lung adenocarcinoma. Computed tomography images of PMA show pneumonia-like findings, solitary pulmonary nodules or ground-glass opacity with consolidation. Misdiagnosis can delay genetic diagnosis.

Metabolic restoration: Rhubarb polysaccharides as a shield against non-alcoholic fatty liver disease.

Non-alcoholic fatty liver disease (NAFLD) accounts for remarkable burden of death and costs worldwide with no recommended pharmacological intervention for the clinical management. This study aimed to investigate the efficacy and underlying mechanisms of rhubarb-derived polysaccharides (RP) in mitigating high-fat diet (HFD)-induced NAFLD and to analyze the primary monosaccharide components of RP. Forty male C57BL/6 mice were subjected to a dietary intervention consisting of either a high fat or chow diet for a duration of 12 weeks.

Albumin Promotes the Absorption of Pb in the Intestine: A Possible Pathway Linking to the High Absorption of Pb in Adolescence.

High blood lead (Pb) levels have long been a significant environmental issue affecting the health and development of adolescents. However, the main reasons behind this phenomenon, especially the absorption and transportation processes of Pb in the intestine, have not been elucidated, which is the major barrier to reducing blood Pb levels in the human body, especially in adolescents. In this study, we explored the intestinal absorption process of Pb in rats of different ages at environmentally relevant concentrations.

A Bidirectional Mendelian Randomization Study of Tea-Drinking Habits and Risk of Elevated Serum Uric Acid Levels.

Background: Although recent animal experiments have revealed that tea intake improves elevated serum uric acid (SUA) levels, a causal link between the consumption of different types of tea and SUA levels remains undetermined.

Methods: Bidirectional Mendelian randomization (MR) analysis based on genome-wide association studies was used to assess the causal relationship between consumption of different types of tea and the risk of elevated SUA levels in European and Asian populations.

Results: Forward MR analysis showed that tea intake was significantly associated with lower SUA levels (p = 0.

Molecular heterogeneity in pediatric sepsis: identification of oxidative stress-related subtypes and diagnostic biomarkers through integrated bioinformatics analysis.

Background: Pediatric sepsis is a life-threatening condition characterized by a dysregulated immune response to infection, often involving heightened oxidative stress. Understanding the molecular heterogeneity of sepsis can provide insights into potential therapeutic targets and diagnostic biomarkers.

Methods: Machine learning approaches were employed to identify diagnostic biomarkers.

Characterization of gene expression profiles in Alzheimer's disease and osteoarthritis: A bioinformatics study.

Background: Alzheimer's disease (AD) and Osteoarthritis (OA) have been shown to have a close association in previous studies, but the pathogenesis of both diseases are unclear. This study explores the potential common molecular mechanisms between AD and OA through bioinformatics analysis, providing new insights for clinical treatment strategies.

Methods: The AD and OA-related datasets were downloaded from the gene expression database GEO.

Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8 T-cell antitumor activity via the non-canonical P53/STING pathway.

Background: Clofarabine (Clo) is a Food and Drug Administration (FDA)-approved drug for the treatment of acute lymphoblastic leukemia; however, its effects on solid tumors remain largely unknown.

Methods: In vitro and in vivo experiments have demonstrated the cytotoxic effects of Clo on melanoma and lung cancer. The molecular mechanisms of Clo-induced tumor cell death were analyzed using western blotting, ELISA, reverse transcription-PCR, immunofluorescence, co-immunoprecipitation (CO-IP), short hairpin RNA, co-culture, chromatin immunoprecipitation, and flow cytometry.

Feasibility and Safety of Pulsed-Field Ablation for Persistent Atrial Fibrillation: A Prospective Study.

Introduction: Pulsed-field ablation (PFA) is a novel nonthermal ablation approach using rapid electrical pulses to cause cardiac cell apoptosis via electroporation. Our study aims to investigate the feasibility and safety of PFA for persistent atrial fibrillation (PeAF).

Methods: Thirty-two consecutive patients diagnosed with PeAF were enrolled in our study.

The role of the estimated glomerular filtration rate and body roundness index in the risk assessment of uric acid-lowering therapy-resistant gout in U.S. adults: evidence from the National Health and Nutrition Examination Survey (2007-2018).

Objective: To explore the risk factors for uric acid-lowering therapy-resistant gout (UALT-RG) and its relationships with the estimated glomerular filtration rate (eGFR), body roundness index (BRI), and visceral adiposity index (VAI) 2007-2018 National Health and Nutrition Examination Survey (NHANES) data.

Methods: We calculated the BRI using waist circumference and standing height; the VAI using triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), and body mass index (BMI); and the eGFR from serum creatinine levels. We also collected gout data.

Research on desiliconization of brown corundum fly dust and bauxite based on roasting-alkali leaching method.

The raw material for smelting brown corundum is high-quality bauxite. As the quality of bauxite decreases, the main impurity, silicon content, increases, which affects the product quality and smelting energy consumption. Additionally, the smelting process produces a significant amount of brown corundum fly dust (BCFD) with a low utilization rate, resulting in resource wastage.

Chain assembly of Rhodococcus bacteria with O-doped g-CN for photocatalysis mediated high-performance partial nitrification: From nitrite resource evolution to device application.

Nitrogen conversion via partial nitrification-anammox (PN/A), utilizing nitrite as a key intermediate, is an ideal low-carbon approach for wastewater nitrogen removal. However, the partial nitrification process, which is rate-limited and relies on less common bacteria with slow reaction kinetics, poses challenges for high-throughput PN/A implementation. Herein, we developed a microbial/photocatalysis coupling system using Rhodococcus bacterial and O-doped g-CN (OCN) photocatalysts.

Intrinsic gallium-68 labeling of nanoclays for tracking.

Intrinsic gallium-68 labeling of nanoclays was developed with high labeling yield and radiostability that did good for their tracking.Image 1.

Pro-adrenomedullin as an independent predictive biomarker for heart failure in atrial fibrillation and flutter.

Aims: This study aimed to investigate potential biomarkers for predicting incident heart failure (HF) in patients with atrial fibrillation and flutter (AF and AFL), utilizing proteomic data from the UK Biobank Pharma Proteomics Project (UKB-PPP).

Methods: This study analysed data from AF and AFL patients, split into discovery (n = 1050) and replication (n = 305) cohorts. Plasma biomarkers were screened using a multivariable-adjusted Cox proportional hazards model.

Ferroptosis and tumor immunity.

Ferroptosis is a unique form of cell death driven by iron-dependent lipid peroxidation, with regulatory mechanisms involving metabolic dysregulation and imbalance in redox systems. Ferroptosis is closely related to various immune cells in the tumor immune microenvironment, including both anti-tumor and pro-tumor immune cells, and it demonstrates significant potential in tumor immunotherapy. A systematic review of the regulatory mechanisms of ferroptosis and its relationship with immune cells can provide deeper insights into its application prospects in tumor immunotherapy.

Mechanism of Yinxu Weitong Capsule in the treatment of precancerous lesions of gastric cancer based on network pharmacology and experimental validation.

Ethnopharmacological Relevance: Yinxu Weitong Capsule (YXWTC) is a Chinese patent medicine used to treat chronic gastritis. However, its efficacy and mechanisms of action in treating precancerous lesions of gastric cancer (PLGC) remain unclear.

Aim Of The Study: To evaluate the effects of YXWTC on PLGC and explore the underlying mechanisms.

Real-world efficacy of transfusion with liberal or restrictive strategy in traumatic brain injury.

Objective: The short-term efficacy of red blood cell (RBC) transfusion among general traumatic brain injury (TBI) patients is unclear.

Methods: We used the MIMIC database to compare the efficacy of liberal (10 g/dL) versus conservative (7 g/dL) transfusion strategy in TBI patients. The outcomes were neurological progression (decrease of Glasgow coma scale (GCS) of at least 2 points) and death within 28 days of ICU admission.