Publications by authors named "Niall Gallop"
Article Synopsis
- FOCUS4 was a clinical trial for advanced colorectal cancer from 2014 to 2020, focusing on molecular profiling of tumor samples to guide patient treatment and randomization.
- The trial involved analyzing 1,291 tumor samples using DNA extraction and immunohistochemistry, initially employing pyrosequencing and later next-generation sequencing for thorough mutation status assessment.
- Despite facing logistical challenges like poor sample quality and integration with health services, the laboratories achieved high assay success rates (98% concordance) and developed effective biomarker testing protocols for the trial.
Aims: Screening all patients newly diagnosed with colorectal cancer (CRC) for possible Lynch syndrome (LS) has been recommended in the United Kingdom since the National Institute for Health and Care Excellence (NICE) released new diagnostics guidance in February 2017. We sought to validate the NICE screening pathway through a prospective regional programme throughout a 5.2-million population during a 2-year period.
View Article and Find Full Text PDFPurpose: There is potential for fecal microbiome profiling to improve colorectal cancer screening. This has been demonstrated by research studies, but it has not been quantified at scale using samples collected and processed routinely by a national screening program.
Experimental Design: Between 2016 and 2019, the largest of the NHS Bowel Cancer Screening Programme hubs prospectively collected processed guaiac fecal occult blood test (gFOBT) samples with subsequent colonoscopy outcomes: blood-negative [ = 491 (22%)]; colorectal cancer [ = 430 (19%)]; adenoma [ = 665 (30%)]; colonoscopy-normal [ = 300 (13%)]; nonneoplastic [ = 366 (16%)].