Publications by authors named "Niaboula Kone"
Background: Limited data exist on drug resistance and antiretroviral treatment (ART) outcomes in HIV-1-infected children in West Africa. We determined the prevalence of baseline resistance and correlates of virologic failure (VF) in a cohort of ART-naive HIV-1-infected children <10 years of age initiating ART in Mali.
Methods: Reverse transcriptase and protease genes were sequenced at baseline (before ART) and at 6 months.
Introduction: Current knowledge on morbidity and mortality in HIV-infected children comes from data collected in specific research programmes, which may offer a different standard of care compared to routine care. We described hospitalization data within a large observational cohort of HIV-infected children in West Africa (IeDEA West Africa collaboration).
Methods: We performed a six-month prospective multicentre survey from April to October 2010 in five HIV-specialized paediatric hospital wards in Ouagadougou, Accra, Cotonou, Dakar and Bamako.
Article Synopsis
- HIV-2 is primarily found in West Africa, and there are currently no solid guidelines for its diagnosis and treatment, prompting the creation of a collaborative research network to address these gaps.
- Data was collected from 1,754 patients across 13 clinics in five West African countries, detailing ART initiation ages, clinical stages, and CD4 counts among HIV-2 and dual-infection patients.
- Results showed that while there was some increase in CD4 counts after ART, management and treatment outcomes indicated that current clinical practices are insufficient, highlighting a need for further research and clinical trials.