Synopsis of recent research by authors named "Nia Soetandyo"
- Nia Soetandyo's research primarily focuses on the mechanisms of endoplasmic reticulum-associated degradation (ERAD), investigating the roles of ubiquitin ligases, deubiquitinases, and associated chaperones in maintaining protein quality control within cells
- Key findings highlight the complex interactions between proteins involved in ERAD, such as the identification of the Bag6 complex and its role in preventing aggregation of misfolded proteins en route to the proteasome, enabling efficient degradation
- Soetandyo's studies also reveal the impact of reactive oxygen species on the activity of deubiquitinases, showcase the mechanisms of viral evasion of immune processes involving protein dislocation, and elucidate the significance of charged residues in the quality control of T-cell receptors in the ER
