Publications by authors named "Ni-Na Hong"
Article Synopsis
- Adipocytes primarily store fatty acids, but they have a low synthesis rate, raising questions about the reason behind this.
- Excessive fatty acid synthesis in these cells can trigger necroptosis (a form of cell death) and lead to a condition called lipodystrophy, where there's an abnormal distribution of fat.
- The study identifies MED20 as a negative regulator of fatty acid synthesis and shows that reducing reactive oxygen species (ROS) can improve metabolic issues in models of lipodystrophy, underscoring the role of ROS in these diseases.
MED20 is a non-essential subunit of the transcriptional coactivator Mediator complex, but its physiological function remains largely unknown. Here, we identify MED20 as a substrate of the anti-obesity CRL4-WDTC1 E3 ubiquitin ligase complex through affinity purification and candidate screening. Overexpression of WDTC1 leads to degradation of MED20, whereas depletion of WDTC1 or CUL4A/B causes accumulation of MED20.
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