Publications by authors named "Ni-Chang Fu"
The function and survival of melanocytes is regulated by an elaborate network of paracrine factors synthesized mainly by epidermal keratinocytes (KCs). KCs and melanocytes respond to UV exposure by eliciting a tanning response. However, how KCs and melanocytes interact in the absence of UV exposure is unknown.
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- Psoriasis involves excessive skin cell growth and immune cell infiltration, with the exact causes remaining uncertain.
- Researchers found that glycyl-tRNA synthetase (GARS), typically involved in protein synthesis, is overexpressed in the skin and blood of psoriasis patients, promoting skin inflammation and abnormal growth when present in high levels.
- The study suggests that targeting GARS could be a potential new treatment strategy for psoriasis, as reducing its expression showed improvements in inflammation and skin condition in laboratory models.
Proinflammatory cytokines, such as IL-1β, are important mediators of psoriasis. UBE2L3, an E2 enzyme, is thought to be an indirect target of IL-1β secretion by binding to ubiquitin ligases such as TRIM21. However, its role in psoriasis remains unknown.
View Article and Find Full Text PDFBackground: The Isoleucyl-tRNA synthetase (IARS) catalyzes isoleucine to the corresponding tRNA, maintaining the accuracy of gene translation. Its role in psoriasis has been not investigated so far. In this study, we aimed to investigate the mechanisms underlying the efficacy of IARS inhibitor, mupirocin, treatment for psoriasis.
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