Intelligent identification and warning method of disc cutter abnormal wear in TBM construction based on extreme learning machine.

Abnormal cutter wear has a serious impact on TBM construction. If not found in time, it may lead to the cutterhead overall failure. Aiming at this problem, a general model and method to identify and warn the abnormal cutter wear using Extreme Learning Machine (ELM) is proposed.

Evaluation of Salt Resistance of Six Apple Rootstocks.

Apples ( are important fruits in China; however, salt stress is severe in northern regions, and the key to plant resistance to salt stress lies in the rootstock. Therefore, it is necessary to explore rootstocks with strong salt resistance for the development of the apple industry. This study used tissue culture seedlings of six apple rootstocks, namely, '71-3-150', '54-118', 'M9T337', 'GM256', 'ML176', and 'ML2', as experimental materials.

The detrimental effects and mechanisms of Orlistat in disrupting energy homeostasis and reproduction in Daphnia magna.

Orlistat (ORL) has been employed as an anti-obesity pharmaceutical for several decades. Given its low absorption rate, the majority of administered ORL is excreted into the environment with feces. It is crucial to collect scientific information regarding the possible ecological risks associated with ORL.

Application of artificial intelligence-based dual source CT scanning in the differentiation of lung adenocarcinoma in situ and minimally invasive adenocarcinoma.

Background And Objective: Lung adenocarcinoma is the most common type of lung cancer with highly incidence and mortality. Due to the overlap of morphological features, it is difficult to distinguish clinically between preinvasive lesions (in situ adenocarcinoma, AIS) and invasive lesions (minimally invasive adenocarcinoma, MIA), which appear as ground glass cloudy nodules. This study was performed to probe the application value of artificial intelligence (AI)-based dual source CT scanning in the differentiation of AIS as well as MIA.

Vibration prediction and analysis of the main beam of the TBM based on a multiple linear regression model.

The vibration of tunnel boring machine (TBM) is very difficult to monitor on sites, and related research on prediction methods is rare. Based on the field tunnelling test of a TBM in the Xinjiang Ehe project, the vibration information of the main beam of the TBM under different surrounding rock conditions is collected. The relationships among the tunnelling parameters, surrounding rock parameters and vibration parameters were studied.

E2F family play important roles in tumorigenesis.

Tumors are serious threats to human health. The transcription factors are regarded as the potential targets for tumor treatment. As an important family of transcription factors, E2F family transcription factors (E2Fs) play vital roles in cell proliferation and regulation.

Nitrogen addition increased soil particulate organic carbon via plant carbon input whereas reduced mineral-associated organic carbon through attenuating mineral protection in agroecosystem.

Nitrogen (N) addition can have substantial impacts on both aboveground and belowground processes such as plant productivity, microbial activity, and soil properties, which in turn alters the fate of soil organic carbon (SOC). However, how N addition affects various SOC fractions such as particulate organic carbon (POC) and mineral-associated organic carbon (MAOC), particularly in agroecosystem, and the underlying mechanisms remain unclear. In this study, plant biomass (grain yield, straw biomass, and root biomass), soil chemical properties (pH, N availability, exchangeable cations and amorphous Al/Fe - (hydr) oxides) and microbial characteristics (biomass and functional genes) in response to a N addition experiment (0, 150, 225, 300, and 375 kg ha) in paddy soil were investigated to explore the predominant controls of POC and MAOC.

Adverse effects of sulfamethoxazole on locomotor behavior and lipid metabolism by inhibiting acetylcholinesterase and lipase in Daphnia magna.

Sulfamethoxazole (SMZ), a kind of sulfonamide antibiotic, is widely used in both human and veterinary medicine. Frequent detection of SMZ in natural aquatic environments has prompted growing attention and posed ecological risks to the ecosystem and human health. In this study, we investigated the ecotoxicological properties of SMZ upon Daphnia magna, and the mechanisms of the deleterious effects of SMZ were attempted to be elucidated by investigating a chain of parameters, including survival, reproduction, growth, locomotor behavior, metabolism, as well as levels of related enzyme activity and gene expression.

Resveratrol inhibits HeLa cell proliferation by regulating mitochondrial function.

The beneficial roles of resveratrol (RES) in affecting proliferation of multiple cancer cells have attracted intensive attention. However, the underlying mechanism remains unclear. This study aims to bridge the knowledge gap by investigating RES-induced growth inhibition of HeLa cells.

Desiccation does not drastically increase the accessibility of exogenous DNA to nuclear genomes: evidence from the frequency of endosymbiotic DNA transfer.

Background: Although horizontal gene transfer (HGT) is a widely accepted force in the evolution of prokaryotic genomes, its role in the evolution of eukaryotic genomes remains hotly debated. Some bdelloid rotifers that are resistant to extreme desiccation and radiation undergo a very high level of HGT, whereas in another desiccation-resistant invertebrate, the tardigrade, the pattern does not exist. Overall, the DNA double-strand breaks (DSBs) induced by prolonged desiccation have been postulated to open a gateway to the nuclear genome for exogenous DNA integration and thus to facilitate the HGT process, thereby enhancing the rate of endosymbiotic DNA transfer (EDT).

Facile Preparation of a Superhydrophobic iPP Microporous Membrane with Micron-Submicron Hierarchical Structures for Membrane Distillation.

A facile method combining micro-molding with thermally-induced phase separation (TIPS) to prepare superhydrophobic isotacticpolypropylene (iPP) microporous membranes with micron-submicron hierarchical structures is proposed in this paper. In this study, the hydrophobicity of the membrane was controlled by changing the size of micro-structures on the micro-structured mold and the temperature of the cooling bath. The best superhydrophobicity was achieved with a high water contact angle (WCA) of 161° and roll-off angle of 2°, which was similar to the lotus effect.

Characterization of Human Dosage-Sensitive Transcription Factor Genes.

Copy number changes in protein-coding genes are detrimental if the consequent changes in protein concentrations disrupt essential cellular functions. The dosage sensitivity of transcription factor (TF) genes is particularly interesting because their products are essential in regulating the expression of genetic information. From four recently curated data sets of dosage-sensitive genes (genes with conserved copy numbers across mammals, ohnologs, and two data sets of haploinsufficient genes), we compiled a data set of the most reliable dosage-sensitive (MRDS) genes and a data set of the most reliable dosage-insensitive (MRDIS) genes.

Heterologous expression and biochemical characterization of a thermostable xylulose kinase from Bacillus coagulans IPE22.

Xylulose kinase is an important enzyme involved in xylose metabolism, which is considered as essential biocatalyst for sustainable lignocellulosic-derived pentose utilization. Bacillus coagulans IPE22 is an ideal bacterium for refinery due to its strong ability to ferment xylose at high temperature. However, the B.

[Differentially expressed genes identified in the main olfactory epithelium of mice with deficiency of adenylate cyclase 3 by using suppression subtractive hybridization approach].

Adenylate cyclase 3 (AC3) is one of the major players in the olfactory signaling within the main olfactory epithelium (MOE) of mice. However, we are not ascertained whether deficiency of AC3 will lead to the differential expression of related genes in the MOE. Forward and reverse subtractive libraries were constructed by suppression subtractive hybridization (SSH) approach, with MOEs from AC3(-/-) and AC3(+/+) mice.

[Estimation of soil organic carbon density and storage in Zhejiang Province of East China by using 1:50000 soil database].

As an important component of the carbon pool of terrestrial ecosystem, soil carbon pool plays a key role in the studies of greenhouse effect and global change. By using a 1:50000 soil database, the organic carbon density in the 0-100 cm layer of 277 soil species in Zhejiang Province was estimated, and the soil organic carbon (SOC) density and storage in the whole Province as well as the spatial distribution of the SOC density and storage in the main soil types of the Province were analyzed. In the whole Province, the SOC density ranged from 5 kg.

Glucocorticoids improve renal responsiveness to atrial natriuretic peptide by up-regulating natriuretic peptide receptor-A expression in the renal inner medullary collecting duct in decompensated heart failure.

In heart failure, the renal responsiveness to exogenous and endogenous atrial natriuretic peptide (ANP) is blunted. The mechanisms of renal hyporesponsiveness to ANP are complex, but one potential mechanism is decreased expression of natriuretic peptide receptor-A (NPR-A) in inner medullary collecting duct (IMCD) cells. Newly emerging evidence shows that glucocorticoids could produce potent diuresis and natriuresis in patients with heart failure, but the precise mechanism is unclear.