Hybridization of short-range and long-range charge transfer boosts room-temperature phosphorescence performance.

At present, mainstream room-temperature phosphorescence (RTP) emission relies on organic materials with long-range charge-transfer effects; therefore, exploring new forms of charge transfer to generate RTP is worth studying. In this work, indole-carbazole was used as the core to ensure the narrowband fluorescence emission of the material based on its characteristic short-range charge-transfer effect. In addition, halogenated carbazoles were introduced into the periphery to construct long-range charge transfer, resulting in VTCzNL-Cl and VTCzNL-Br.

Macrophage Membrane-Encapsulated Dopamine-Modified Poly Cyclodextrin Multifunctional Biomimetic Nanoparticles for Atherosclerosis Therapy.

Atherosclerotic plaques exhibit high cholesterol deposition and oxidative stress resulting from high reactive oxygen species (ROS). These are the major components in plaques and the main pro-inflammatory factor. Therefore, it is crucial to develop an effective therapeutic strategy that can simultaneously address the multiple pro-inflammatory factors removing cholesterol and inhibiting the overaccumulated ROS.

Phenylboronic acid functionalized dextran loading curcumin as nano-therapeutics for promoting the bacteria-infected diabetic wound healing.

Chronic bacterial infections, excessive inflammation, and oxidative stress significantly hinder diabetic wound healing by prolonging the inflammatory phase and complicating the healing process. In this study, phenylboronic acid functionalized dextran (PODP) was developed to encapsulate curcumin, referred to as PODP@Cur. Experimental results indicate that PODP significantly improves the water solubility of curcumin and exhibits synergistic biological activity both in vitro and in vivo.

An integrated microfluidic platform for nucleic acid testing.

This study presents a rapid and versatile low-cost sample-to-answer system for SARS-CoV-2 diagnostics. The system integrates the extraction and purification of nucleic acids, followed by amplification via either reverse transcription-quantitative polymerase chain reaction (RT-qPCR) or reverse transcription loop-mediated isothermal amplification (RT-LAMP). By meeting diverse diagnostic and reagent needs, the platform yields testing results that closely align with those of commercial RT-LAMP and RT‒qPCR systems.

Uneven agricultural contraction within fast-urbanizing urban agglomeration decreases the nitrogen use efficiency of crop production.

Diverse development paths among cities within an urban agglomeration can lead to uneven changes in their agricultural production scale, which reshape the inter-city food supply patterns and the spatiotemporal characteristics of nitrogen (N) pollution from the food system. Here, using Guangdong-Hong Kong-Macao Greater Bay Area of China as a case, we found a substantial decrease in N use efficiency of crop production from 45.2% to 29.

Hyaluronic acid-decorated curcumin-based coordination nanomedicine for enhancing the infected diabetic wound healing.

Persistent over-oxidation, inflammation and bacterial infection are the primary reasons for impaired wound repairing in diabetic patients. Therefore, crucial strategies to promote diabetic wound repairing involve suppressing the inflammatory response, inhibiting bacterial growth and decreasing reactive oxygen species (ROS) within the wound. In this work, we develop a multifunctional nanomedicine (HA@Cur/Cu) designed to facilitate the repairing process of diabetic wound.

Correction: Sub-nL thin-film differential scanning calorimetry chip for rapid thermal analysis of liquid samples.

Correction for 'Sub-nL thin-film differential scanning calorimetry chip for rapid thermal analysis of liquid samples' by Sheng Ni , , 2023, , 1926-1934, https://doi.org/10.1039/D2LC01094A.

Metronidazole-loaded polydopamine nanomedicine with antioxidant and antibacterial bioactivity for periodontitis.

This study focused on treating periodontitis with bacterial infection and local over accumulation of reactive oxygen species. Polydopamine nanoparticles (PDA NPs) were exploited as efficient carriers for encapsulated metronidazole (MNZ). The therapeutic efficacy and biocompatibility of PDA@MNZ NPs were investigated through both and studies.

Accelerated Electrophoretic Focusing and Purification of DNA Based on Synchronous Coefficient of Drag Alteration.

Synchronous coefficient of drag alteration refers to a multidimensional transport mechanism where a net drift of molecules is achieved under a zero-time-average alternating motive force by perturbing their drag coefficient synchronously with the applied force. An electrophoretic form of the method is often applied to focus and purify nucleic acids in a gel under rotating electric fields. However, this method requires lengthy operation due to the use of limited field strengths.

Biomimetic nanoparticles to enhance the reverse cholesterol transport for selectively inhibiting development into foam cell in atherosclerosis.

A disorder of cholesterol homeostasis is one of the main initiating factors in the progression of atherosclerosis (AS). Metabolism and removal of excess cholesterol facilitates the prevention of foam cell formation. However, the failure of treatment with drugs (e.

Effect of green finance reform and innovation pilot zone on improving environmental pollution: an empirical evidence from Chinese cities.

Under the strategic deployment of dual carbon goals, China has entered the stage of high-quality development of low-carbon economic transformation. Green finance is an important tool to provide financing support for the development of green low-carbon projects and prevent environmental and climate financial risks. Whether and how it can help the implementation of the dual carbon goals is worth pondering and studying.

Continuous-flow label-free size fractionation of extracellular vesicles through electrothermal fluid rolls and dielectrophoresis synergistically integrated in a microfluidic device.

Extracellular vesicles (EVs) are cell-derived bioparticles that play significant roles in various biological processes including cell-to-cell communication and intercellular delivery. Additionally, they hold great potential as liquid biopsy biomarkers for pre-diagnostic applications. However, the isolation of EV subpopulations, especially exosomes from a biological fluid remains a challenge due to their submicron range.

Sub-nL thin-film differential scanning calorimetry chip for rapid thermal analysis of liquid samples.

Differential scanning calorimetry (DSC) is a popular thermal analysis technique. The miniaturization of DSC on chip as thin-film DSC (tfDSC) has been pioneered for the analysis of ultrathin polymer films at temperature scan rates and sensitivities far superior to those attainable with DSC instruments. The adoption of tfDSC chips for the analysis of liquid samples is, however, confronted with various issues including sample evaporation due to the lack of sealed enclosures.

Clarifying the relationship among green investment, clean energy consumption, carbon emissions, and economic growth: a provincial panel analysis of China.

As a financial activity with the main purpose of ecological protection and environmental governance, green investment has important practical significance for promoting sustainable economic development. Previous studies have not addressed the relationship between green investment, clean energy consumption, carbon emissions, and economic growth. We use panel data from 30 provinces and cities in China from 2003 to 2017 to build a simultaneous equation model, which can evaluate the nonlinear relationship and avoid the endogeneity of the model.

Identifying the status and differences between urban and rural residents' behaviors and attitudes toward express packaging waste management in Guangdong Province, China.

With the rapid development of the express delivery industry, the environmental issues of express packaging waste (EPW) have gradually attracted public attention worldwide. As important participants, consumers' behaviors and attitudes will play a vital role in solving the problem. This study uses the conditional value method (CVM) to evaluate the differences in the attitudes and willingness to pay of urban and rural residents toward EPW in Guangdong Province, China.

Ordered surface crack patterns formed under confinement on fluidic microchannel boundaries in polydimethylsiloxane.

We present ordered surface crack patterns discovered in microfluidic channels/chambers in polydimethylsiloxane (PDMS). The cracks are formed in situ under confinement due to compression applied following an oxygen plasma step in a soft lithography process. The crack patterns are noticeable only after fluorescent labeling and vary with fluidic layout as well as material compliance.

ADORA1 Promotes Hepatocellular Carcinoma Progression via PI3K/AKT Pathway.

Objective: Hepatocellular carcinoma (HCC) is a common malignancy worldwide. Although the contradictory role of ADORA1 has been explored in certain types of cancers, its clinical significance and function in hepatocellular carcinoma cells are largely unknown.

Materials And Methods: The level of ADORA1 in HCC tissues and cells was evaluated by RT-PCR.

The vision of point-of-care PCR tests for the COVID-19 pandemic and beyond.

Infectious diseases, such as the most recent case of coronavirus disease 2019, have brought the prospect of point-of-care (POC) diagnostic tests into the spotlight. A rapid, accurate, low-cost, and easy-to-use test in the field could stop epidemics before they develop into full-blown pandemics. Unfortunately, despite all the advances, it still does not exist.

Rapid Characterization of Biomolecules' Thermal Stability in a Segmented Flow-Through Optofluidic Microsystem.

Optofluidic devices combining optics and microfluidics have recently attracted attention for biomolecular analysis due to their high detection sensitivity. Here, we show a silicon chip with tubular microchannels buried inside the substrate featuring temperature gradient (∇T) along the microchannel. We set up an optical fluorescence system consisting of a power-modulated laser light source of 470 nm coupled to the microchannel serving as a light guide via optical fiber.

Evaluation of urban inland waterway traffic noise using a modified Nord 2000 prediction model.

This study developed a prediction model for estimating urban inland waterway traffic noise emission level. The model based on the Scandinavian Nord 2000 method, which was modified by adding two categories of traffic flow, comprising light and heavy vessels, as well as vessel average speed to the calculating equations. Meanwhile, the influences of the water surface and embankment were also considered in the established model.