[Quality control of zhuanggu shenjin capsules].

Studies have been made on the microscopic identification of red jinseng, dog bone, indian bread, yanhusuo and datura flower in Zhuanggu Shenjin Capsules, as well as on the identification of ginsengside and tetrahydropalmatine by TLC and the determination of icariin by dual wavelength TLC-scanning. The content of the latter compound should be no less than 0.380mg/g and the average rate of recovery 97.

Effects of hyperbaric oxygen on S-180 sarcoma in mice.

The contents of oxygen free radicals (OFRs) and malondialdehyde (MDA) in S-180 sarcoma tissues were measured in four groups of mice: an untreated normoxic group, a normoxic hyperbaric group, a hyperbaric oxygen group, and an HBO group treated with superoxide dismutase (SOD). Measurements were done by electron resonance and spectrophotometry, and observations were made on the volume, weight, necrosis incidence rate of sarcoma tissues, and mortality in all groups. The OFR and MDA content in sarcoma tissues in the HBO group was significantly higher than those of the control groups (P < 0.

The relationship between dietary factors and serum lipids in southern Chinese population samples.

As part of the PRC-USA collaborative research project on the epidemiology of cardiovascular disease, baseline surveys were conducted in four random urban and rural samples in Guangzhou, Guangdong Province in southern China on 334 men and women aged 35-54 in the fall of 1983-84 with the aim of studying the correlation between dietary intakes and serum lipids. Methods standardized by the US Centers for Disease Control were used for measuring different parameters, and quality control was emphasized to assure comparability between workers and farmers. Three 24-hour recalls were collected from each participant in each survey.

Expression levels of IL-6 mRNA in PBMNCs from patients with IDDM, NIDDM and normals by RT-PCR procedure.

Although it has been confirmed that insulin dependent diabetes mellitus (IDDM) is a kind of autoimmune disease, islet cell autoantibodies (ICAs), insulin autoantibodies (IAA) and anti-GAD-glutamic acid decardaxylase antibodies have been found in the sera of patients with IDDM and immunotherapies have been used in some patients with IDDM, yet the manner in which the dysfunctional immunosystem acts on beta cells and causes damage to them remains to be clarified. Recently, possible involvement of the abnormal production of IL-6 in autoimmune symptoms was suggested in patients with cardiac myxomas, Castleman's disease and rheumatoid arthritis. However reports of IL-6 abnormal production in patients with IDDM are rare.

[Changes of Leu-enkephalin in striatum and hypothalamus of rats during hyperbaric oxygen exposure].

The purpose of this study is to investigate the changes of Leu-Enkephalin (L-Enk) content in striatum and hypothalamus of rats during hyperbaric (HBO) oxygen exposure. Thirty-two male rats in the experiment were randomly divided into four groups: normobaric air group, normoxic hyperbaric nitrox group, nonconvulsion HBO group and convulsion HBO group. L-Enk content in striatum and hypothalamus was determined by radioimmunoassay.

Comparative tissue distribution of 125I- and U-14C-labeled recombinant human interleukin-2 in the rat.

The distribution of recombinant human interleukin-2 (rhIL-2) after intravenous administration of 125I- or U-14C-labeled rhIL-2 is reported in the major organs of the rat. Five minutes after the administration of U-14C-labeled rhIL-2, the radioactivity had been rapidly cleared from the plasma, while 38% of the dose was found in the kidneys, confirming that the major site of clearance for rhIL-2 is the kidney. After 1 h, a large fraction of the radioactivity had disappeared from the kidney and was found in the carcass.

[The short-term results of intrapericardial total pneumonectomy in the treatment of advanced lung cancer].

Seventy two cases of lung cancer treated by intrapericardial total pneumonectomy were reported. Pre-operative vital capacity were 50% of the estimated values. After the operation, 5 cases were complicated by respiratory failure, but none was related to pericardiotomy.

[Surgical treatment of destructive pulmonary tuberculosis].

Total pneumonectomy combined with thoracoplasty should be applied to tuberculosis-destructed lungs unresponsive to anti-TB treatment, of which the clinical symptoms are evident and both the maximum ventilation and vital capacity are 50% of the estimated values, and in which no organic disorders of the heart are found on examination. But for those below the age of 18, or with the left lung destructed alone, obvious left deviation of the mediastinum, relatively smaller residual cavity on the left side and negative sputum, simple total pneumonectomy should be considered. Postoperative care to improve the resistance of the respiratory system and to prevent recurrent infection is of significance to better long-term response.

Primary dapsone resistance in China.

Ninety-seven strains of Mycobacterium leprae recovered from patients with previously untreated multibacillary leprosy were tested for dapsone susceptibility. The specimens originated from Shanghai Municipality, Jiang-su Province and Fu-jian Province. Approximately 28% of the strains either did not infect the mice or the results of susceptibility were inconclusive due to the low proportion of viable organisms in the bacterial populations.

Antimycobacterial activities of two newer ansamycins, R-76-1 and DL 473.

The antimycobacterial activities of two newer ansamycins, isobutylpiperazinylrifamycin SV (R-76-1) and cyclopentylrifamycin SV (DL 473), were compared with those of rifampin (RMP) both in vitro and in vivo. In terms of minimal inhibitory concentrations against a number of cultivable mycobacteria, R-76-1 was about eight times more active in vitro than RMP; whereas DL 473 was only slightly more active than RMP. Therapeutic activities of R-76-1 versus RMP and DL 473 versus RMP were compared, respectively, in the experimental infection of mice with Mycobacterium lepraemurium by different treatment schedules (immediate and delayed) and dosage regimens.