Publications by authors named "Nhu Ngoc Quynh Vo"
Natural drimane-type sesquiterpenes, including drimenol, display diverse biological activities. These active compounds are distributed in plants and fungi; however, their accumulation in bacteria remains unknown. Consequently, bacterial drimane-type sesquiterpene synthases remain to be characterized.
View Article and Find Full Text PDFPentacyclic triterpenes may be active agents and provide a rich natural resource of promising compounds for drug development. The inhibitory activities of 29 natural oleanane and ursane pentacyclic triterpenes were evaluated against four major enzymes involved in the inflammatory process: 5-LOX, 15-LOX-2, COX-1, and COX-2. It was found that 3--acetyl-β-boswellic acid potently inhibited human 15-LOX-2 (IC = 12.
View Article and Find Full Text PDFArticle Synopsis
- Researchers studied 41 types of triterpenoid saponins and sapogenins, determining how their structure affects hemolytic activity (the destruction of red blood cells).
- They found that oleanane-type sapogenins were more effective at causing hemolysis compared to ursane and dammarane types, with certain polar groups enhancing this effect.
- The study highlights the importance of sugar structures and functional groups at specific locations on the molecules in determining their potential toxicity, offering valuable insights for future drug development.