Publications by authors named "Nhan Hau Tran"
The potential of standard methods of radiation therapy is limited by the dose that can be safely delivered to the tumor, which could be too low for radical treatment. The dose efficiency can be increased by using radiosensitizers. In this study, we evaluated the sensitizing potential of biocompatible iron oxide nanoparticles coated with a dextran shell in A172 and Gl-Tr glioblastoma cells in vitro.
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- - The text discusses the growing interest in improving proton therapy (PT) methods in radiation oncology to enhance their biological effectiveness.
- - It highlights the use of binary technologies that enhance proton radiation's damaging effect by selectively targeting radiosensitizers to specific tissues.
- - The review focuses on proton boron capture therapy (PBCT), which aims to increase tumor dose by using a reaction between protons and boron isotopes, generating three alpha particles, and summarizes relevant theoretical and experimental studies.
Article Synopsis
- Proton boron capture therapy (PBCT) aims to improve proton therapy's effectiveness by utilizing proton-boron fusion reactions that theoretically increase dose delivery in cancer cells.
- The study investigated the effectiveness of sodium borocaptate (BSH) in enhancing proton radiation's effects on glioma cells, showing only minimal improvement in cell viability and colony formation after treatment.
- Findings suggest that the anticipated benefits of PBCT may not materialize due to the complicated interactions within irradiated tissues, indicating a need for further research into secondary effects rather than just direct dose enhancements.