Publications by authors named "Nguyen-Thi-Bich H"
Background: Obstructive sleep apnea (OSA) is the most common form of respiratory disorders during sleep in children, especially those with severe asthma. However, optimal treatment of asthma might significantly improve OSA severity.
Methods: It was a cohort study including children aged >5 years old and diagnosed with asthma according to GINA (Global Initiative for Asthma).
Introduction: Inhaled corticosteroid (ICS) is the most widely used and effective treatment of asthma. However, some patients do not respond to ICS, which might be due to various genetic factors. Hence, understanding the genetic factors involved in the ICS response could help physicians to individualize their treatment decision and action plans for given patients.
View Article and Find Full Text PDFIn children with asthma, the responsiveness of inhaled corticosteroids (ICS) is depended on asthma endotype and phenotype. This study aimed to describe the clinical and biological characteristics, and its correlation with polymorphism of rs28364072 in FCER2 of asthmatic children. This work aimed to study the correlation between fractional concentration of exhaled nitric oxide (FE) level and rs28364072 polymorphism of FCER2 gene with ICS responsiveness and disease control in children with asthma.
View Article and Find Full Text PDFNumerous studies have examined the association between pharmacogenetic effects and the response to inhaled corticosteroids (ICS) in patients with asthma. In fact, several single nucleotide polymorphisms of a number of candidate genes have been identified that might influence the clinical response to ICS in children with asthma. Their direct or indirect effects depend on their role in the inflammatory process in asthma or the anti-inflammatory action of corticosteroids, respectively.
View Article and Find Full Text PDFArticle Synopsis
- Fractional exhaled nitric oxide (FENO) serves as a key biomarker for assessing airway inflammation in children with asthma and supports diagnosis and treatment, particularly for those using inhaled corticosteroids.
- The study evaluated FENO levels in 42 Vietnamese children with uncontrolled asthma, analyzing correlations with atopic status, blood eosinophil levels, FCER2 gene mutations, and asthma control, finding significant relationships particularly with blood eosinophils and allergen sensitivity.
- After three months of treatment, FENO levels significantly decreased, indicating treatment efficacy, though a notable percentage of children still had uncontrolled asthma, highlighting the need for ongoing monitoring and management.