Publications by authors named "Nguyen-Thanh Phuong"
To meet various industrial requirements such as ease of motion, scalability, and cost efficiency, it is necessary to innovate the design of robotic platforms. In this research, a novel approach, from mechanical design to control implementation, is introduced for launching a robotic platform using a parallelogram mechanism. First, a reverse engineering process is applied, progressing from kinematics to dynamics.
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- Austronesian is the second-largest language family globally, mainly found in Island Southeast Asia and Oceania, with limited understanding of its spread in Mainland Southeast Asia.
- This study analyzed genetic data from 369 individuals with mitogenomes and 170 individuals' Y-chromosomal SNPs from Vietnamese Austronesian and neighboring Austroasiatic groups to uncover population connections.
- Results showed some genetic consistency with matrilocality among certain VN-AN groups and closer genetic ties with VN-AA groups, indicating that the spread of AN speakers involved both cultural and demic diffusion.
Article Synopsis
- The paper introduces CORING, a new method for pruning filters in neural networks that focuses on efficient tensor decomposition, moving away from traditional vectorized techniques.
- CORING utilizes the HOSVD tensor decomposition to maintain the multidimensional quality of filters while significantly lowering computational complexity.
- Experiments show CORING surpasses existing methods in reducing MACs (Multiply-Accumulate operations) and parameters, while improving validation accuracy across various vision tasks, supported by an in-depth ablation study and qualitative results.
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- Epithelia require mechanical resistance to maintain tissue integrity, with tight junctions (TJs) playing a significant but not fully understood role.
- Research shows that cells lacking TJs due to missing proteins claudins and JAM-A experience junction fractures when stretched.
- Further studies indicate that actin organization and the protein CAR are essential for maintaining the integrity of apical junctions in epithelial cells.
Enhanced Network Compression Through Tensor Decompositions and Pruning.
IEEE Trans Neural Netw Learn Syst
March 2024
Article Synopsis
- NORTON is a new network compression method that combines tensor decompositions and pruning to improve model efficiency and performance.
- It features a unique filter decomposition process that maintains the complex properties of the network weights while allowing for more detailed analysis.
- Extensive testing shows that NORTON outperforms existing state-of-the-art techniques in both accuracy and complexity, with code available for further research.
Article Synopsis
- Antimicrobial photodynamic therapy (APDT) utilizes light-activated compounds called photosensitizers to combat antibiotic-resistant bacteria.
- This study tested various plant extracts as photosensitizers against gram-negative (Pseudomonas aeruginosa) and gram-positive (Staphylococcus aureus) bacteria, showing them to be effective in generating singlet oxygen for bacterial inactivation.
- The results indicated that exposing P. aeruginosa to 405 nm light produced a significant reduction in bacterial counts, while S. aureus showed a similar effectiveness across all tested light wavelengths and doses.
Article Synopsis
- FAF1 is a protein that interacts with various partners and has important roles in cellular processes, particularly in modulating the mineralocorticoid receptor through specific SUMO-interacting motifs.
- The study found that SAP130 can be modified by SUMO1 at specific lysine residues, and mutations at these sites affect SAP130's association with FAF1 and its cellular functions.
- Furthermore, FAF1 enhances the degradation of SUMO-modified SAP130, thus regulating its ability to repress transcription and promote cell growth, highlighting FAF1's role in controlling the stability and activity of SAP130 through sumoylation.
Article Synopsis
- - The study developed non-toxic quantum dots (QDs) using a starch paste stabilizer, revealing improved compatibility with antibodies due to the -CH-OH group in the starch.
- - Different concentrations of manganese-doped ZnS in the QDs were tested, finding that a 3% Mn ratio yielded the best luminescence and quantum yield, enhancing fluorescence intensity compared to other formulations.
- - The incorporation of protein A and EDC bridging technology demonstrated that the ZnSe/ZnS:3%Mn/ZnS-starch QDs exhibited strong signals and sensitivity, while being non-toxic to harmful bacteria like E. coli and MRSA.
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- Psidium guajava L. (guava) has immune-modulatory effects in humans and some fish, but the specific molecular mechanisms in fish are not fully understood.
- This study tested two guava extract fractions (dichloromethane and ethyl acetate) on striped catfish both in lab experiments (in vitro) and live fish (in vivo) to assess their immune responses.
- Results showed that the guava fractions can differently affect immune responses, particularly enhancing pathways related to inflammation and apoptosis, and suggest that these extracts could be beneficial for fish health by modulating immune and inflammatory pathways.
Polymer-based micro-optical components are very important for applications in optical communication. In this study, we theoretically investigated the coupling of polymeric waveguide and microring structures and experimentally demonstrated an efficient fabrication method to realize these structures on demand. First, the structures were designed and simulated using the FDTD method.
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- The metabotropic glutamate receptor 1 (mGlu) is crucial for synaptic transmission and neuronal plasticity, but its protein interactions in specific brain regions, like the cerebellum, are not fully understood.
- Researchers used a proteomic approach to identify associated proteins, discovering well-known complexes and a novel interactor called KCTD12.
- Further experiments showed that KCTD12 and mGlu are located close to each other in Purkinje cell spines, suggesting a potential but indirect interaction, without being mediated by GABA receptors.
Article Synopsis
- A One Health surveillance approach was used in Vietnam to monitor biological samples from bats, pigs, and humans for zoonotic viruses at high-risk locations.
- Over 1,600 samples were tested for five types of viruses, revealing a significant presence of coronaviruses in bats near pigs, indicating a potential spillover risk due to high pig density.
- While direct human infections from these bat viruses weren't found, serological tests indicated possible past exposure to other dangerous viruses, showcasing the importance of coordinated surveillance in tracking viral threats.
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- Targeted radionuclide therapy (TRT) and immunotherapy are emerging cancer treatments, with research focused on their potential combinations for enhanced effectiveness.
- TRT offers the advantage of treating multiple disease sites through intravenous administration, making it particularly useful in cases of metastatic cancer.
- While preclinical studies show promise for combining TRT with immune checkpoint blockade, clinical results have been inconsistent, leading to ongoing trials to better understand their interactions and clinical applications.
Article Synopsis
- - This study introduces a new hybrid algorithm combining particle swarm optimization (PSO) and genetic algorithm (GA) with neural networks to predict leakage current in insulators, enhancing online monitoring for Taiwan's power transmission towers.
- - The algorithm uses local weather data and specific image data related to spark discharges as input to improve prediction accuracy, offering significant reductions in Mean Squared Error (MSE) and Mean Absolute Percentage Error (MAPE) compared to traditional methods.
- - The improved methodology not only increases prediction accuracy but also helps reduce operational and maintenance costs for Taiwan Power Company, demonstrating its practical value in the field.
Combined Gap-Polymerase Chain Reaction and Targeted Next-Generation Sequencing Improve α- and β-Thalassemia Carrier Screening in Pregnant Women in Vietnam.
Tuan-Thanh Lam Doan-Tu Nguyen Quang Thanh Le Duy-Anh Nguyen Diem-Tuyet Thi Hoang Kim Phuong Thi Doan Phuong-Anh Ngoc Vo Thanh-Phuong Thi Nguyen Ngoc-Phuong Thi Cao
Hemoglobin
July 2022
Article Synopsis
- Vietnam has a significant thalassemia issue, with a study of 5,880 pregnant women revealing a 13.13% carrier frequency for thalassemia.
- The breakdown of carriers included 7.82% for α-thalassemia and 5.31% for β-thalassemia, with common mutations identified in both types.
- The study highlights the effectiveness of combining next-generation sequencing with gap-PCR for comprehensive thalassemia screening, estimating that around 5,021 babies could be born with severe thalassemia in Vietnam each year.
Article Synopsis
- Claudin-based tight junctions (TJs) are crucial for cell-cell adhesion in epithelial cells, typically found at the apical region.
- The study investigates the role of scaffolding proteins ZO-1 and ZO-2 in the positioning of TJs by using a mutant form of claudin-3 that does not bind to these proteins.
- Results show that this mutant claudin-3 can still localize and form functional TJs, indicating that the interaction with ZO proteins is not essential for forming TJs at cell contacts.
Article Synopsis
- * This study created a high-quality genome assembly of striped catfish, crucial for the aquaculture industry in Vietnam, resulting in a 788.4 Mb genome with 381 scaffolds and improved structuring into 30 chromosome groups.
- * The new assembly shows significant enhancements over previous versions, including higher identification of repeat elements and BUSCO genes, and will serve as an important genomic resource for research in genetics, conservation, and breeding of striped catfish.
Massively parallel sequencing uncovered disease-associated variant spectra of glucose-6-phosphate dehydrogenase deficiency, phenylketonuria and galactosemia in Vietnamese pregnant women.
Tat-Thanh Nguyen Quang-Thanh Le Diem-Tuyet Thi Hoang Huu Du Nguyen Thi Minh Thi Ha Kim Phuong Thi Doan Lan-Phuong Thi Nguyen Lan Phuong Thi Nguyen
Mol Genet Genomic Med
July 2022
Article Synopsis
- A study in Vietnam assessed the prevalence of inherited metabolic diseases (G6PD, PKU, and GAL) among pregnant women using massively parallel sequencing (MPS), a method that allows for simultaneous screening of multiple genetic variants.
- Out of 3,259 pregnant women screened, 13.8% were found to carry disease-associated variants, with G6PD being the most common and GAL being very rare.
- The findings underscore the importance of routine carrier screening during prenatal care in Vietnam, suggesting MPS as an effective tool for identifying both common and rare genetic variants to aid in public health planning.
Article Synopsis
- Juvenile striped catfish were exposed to increasing salinity levels from freshwater to 20 psu over a 14-day period, and their intestinal microbial profiles and gene expressions were analyzed at the beginning and end of exposure.
- The study found that as salinity increased, the diversity of gut bacteria decreased, with notable changes in specific bacterial genera; Vibrio increased while Akkermansia decreased, and the presence of Sulfurospirillium was higher in fish subjected to saline treatments.
- Additionally, the fish showed changes in gene expression related to osmoregulation and stress response, indicating adaptations to higher salinity levels, especially at 15 and 20 psu.
Article Synopsis
- Researchers studied pangolins and civets in Viet Nam to identify possible sources of SARS-related coronaviruses, screening 696 specimens for various viral RNA, but found most were negative for these viruses.
- They discovered 12 specimens from confiscated pangolins that tested positive for Sarbecoviruses, which were related to coronaviruses found in pangolins from other parts of China.
- Data collection on wildlife confiscation showed that many pangolins in Viet Nam were being trafficked toward consumers in China, highlighting the global trade issue surrounding these animals.
Salinity affects growth performance, physiology, immune responses and temperature resistance in striped catfish (Pangasianodon hypophthalmus) during its early life stages.
Dang Quang Hieu Bui Thi Bich Hang Do Thi Thanh Huong Najlae El Kertaoui Frédéric Farnir Nguyen Thanh Phuong
Fish Physiol Biochem
December 2021
Article Synopsis
- The study investigated how striped catfish larvae responded to increasing salinity levels over a 10-day period, followed by exposure to a heat shock at 39 °C to assess their stress tolerance.
- Results indicated that the highest salinity treatment (20 psu) led to a significantly lower survival rate (28.6%) compared to other levels, with the best survival found at 5 psu (68.9%).
- Additionally, digestive enzyme activities generally increased with salinity, but deformities were more common in fish raised at higher salinities, suggesting optimal rearing conditions are between 5 to 10 psu for improved survival and stress tolerance.
Article Synopsis
- Accurate profiling of recessive diseases in the Vietnamese population is crucial for developing effective carrier screening programs, but minorities are often underrepresented in genetic research.
- A comprehensive study analyzed genetic data from 985 Vietnamese individuals, identifying 118 recessive diseases and 164 variants, with some diseases having significantly higher carrier frequencies compared to global populations.
- The research revealed three prevalent diseases—beta-thalassemia, citrin deficiency, and phenylketonuria—with notable carrier rates, and introduced seven novel pathogenic variants, enhancing the understanding of recessive disorders specific to Vietnamese individuals.
Article Synopsis
- The study focused on how striped catfish (Pangasianodon hypophthalmus) use air-breathing to handle high levels of carbon dioxide (hypercarbia) in water and how this behavior varies with different exposure methods.
- Results showed that the fish can tolerate high hypercarbia, maintaining stable gill ventilation, heart rate, and blood pressure even at elevated CO2 levels.
- Individual fish showed varying responses to air-breathing, with the method of exposure affecting when they started to breathe air; air-breathing generally began at lower CO2 levels during a step-wise approach compared to a progressive one.
Article Synopsis
- A significant portion of the global population suffers from metabolic diseases (MD), with projections indicating a potential doubling of cases in the coming decades, leading to additional health challenges like NAFLD and cardiomyopathy.
- The investigation of genetic factors contributing to MD typically uses biological network analysis but faces issues like data bias and complexity in methodology.
- The proposed approach introduces a straightforward, parameter-free method that considers the effects of database dependence and network topology, helping to identify key genes linked to MD and suggesting new candidates for further research.
Article Synopsis
- * A collaborative investigation in Laos, Vietnam, and Cambodia aimed to assess the interaction between domestic pigs and wild boars, identify risks for ASF transmission, and search for the virus in wild boars.
- * Significant overlap in habitats for domestic pigs and wild boars was found, with confirmed ASF cases in wild boars in Laos and Vietnam, marking the first detection in Southeast Asia and underscoring the need for effective monitoring and biosecurity measures.