Publications by authors named "Nguyen V B Pham"
Saccharomyces cerevisiae Coq8 is a member of the ancient UbiB atypical protein kinase family. Coq8, and its orthologs UbiB, ABC1, ADCK3, and ADCK4, are required for the biosynthesis of coenzyme Q in yeast, E. coli, A.
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- - Coenzyme Q (CoQ) is crucial for energy metabolism and acts as an antioxidant in cells, with deficiencies linked to various diseases and potential benefits from supplementation.
- - The study investigates the human proteins COQ10A and COQ10B, finding that they can restore certain functions in yeast mutants lacking CoQ but do not restore CoQ biosynthesis itself.
- - The findings suggest that yeast Coq10 may depend on interactions with other proteins, like Coq11 (absent in humans), highlighting differences in CoQ biosynthesis pathways between yeast and humans.