Publications by authors named "Nguyen Tuong Ho"
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder afflicting the elderly population worldwide. The identification of potential gene candidates for AD holds promises for diagnostic biomarkers and therapeutic targets. Employing a comprehensive strategy, this study integrated transcriptomic data from diverse data sources, including microarray and single-cell datasets from blood and tissue samples, enabling a detailed exploration of gene expression dynamics.
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- The study aimed to evaluate if using an explainable AI model improves the accuracy and clarity of predicting embryo ploidy status based on various embryonic and clinical data.
- The research involved analyzing a dataset of 1908 blastocyst embryos with multiple machine learning models, where the Random Forest model showed the best performance in predicting ploidy status.
- Findings suggest that XAI techniques, like SHAP and LIME, effectively enhance understanding of the model's predictions, potentially aiding in better embryo selection and patient consultations.
This study investigates the effect of GnRHa pretreatment on pregnancy outcomes in artificial endometrial preparation for frozen-thawed embryo transfer (AC-FET) cycles. A systematic review of English language studies published before 1 September 2022, was conducted, excluding conference papers and preprints. Forty-one studies involving 43,021 participants were analyzed using meta-analysis, with a sensitivity analysis ensuring result robustness.
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- Telemedicine is being utilized in assisted reproduction technology (ART) for remote consultations and patient support, and this study evaluates its benefits through virtual consultations.
- Eleven studies analyzing 4697 patients revealed that telemedicine showed similar success rates in fertility treatments compared to in-office care, with an odds ratio of 1.02.
- Patients using telemedicine reported a high satisfaction rate of 91%, indicating that it could be a valuable complement to traditional fertility treatments without negatively impacting outcomes.
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- The study investigates how factors like age, ethnicity, and BMI affect serum anti-mullerian hormone (AMH) levels in Asian women receiving fertility treatments.
- A total of 4,556 women aged 20-43 from various Asian ethnic backgrounds participated in a multi-center study, revealing that AMH levels decline significantly with age and are influenced by obesity and conditions like polycystic ovarian syndrome (PCOS).
- The findings show a mean AMH level of 3.44 ng/ml across all ages, with optimal PCOS diagnosis at a concentration of 4.0 ng/ml, indicating poorer reproductive outcomes for older women.
Osteopontin (OPN) isoforms, including OPNb and OPNc, promote malignancy and may contribute to the pathogenesis of endometriosis, a benign disorder with multiple characteristics resembling malignant tumors. In our experiments, OPNb and OPNc were significantly overexpressed in both endometriosis and adenomyosis compared to the normal endometrium. Upregulation of CD44v and the epithelial-mesenchymal transition (EMT) process was also present in endometriotic lesions.
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