Modulatory Effect of Cucurbitacin D from on ZNF217 Oncogene Expression in NPM-Mutated Acute Myeloid Leukemia.

The expression of oncogene zinc-finger protein 217 (ZNF217) has been reported to play a central role in cancer development, resistance, and recurrence. Therefore, targeting ZNF217 has been proposed as a possible strategy to fight cancer, and there has been much research on compounds that can target ZNF217. The present work investigates the chemo-preventive properties of cucurbitacin D, a compound with a broad range of anticancer effects, in hematological cancer cells, specifically with regard to its ability to modulate ZNF217 expression.

New Shikimic Acid Derivatives From the Marine-Derived Actinomycete Streptomyces sp. G666 and Their Antimicrobial Activities.

Analysis of an antimicrobial extract from the agar-based culture of the marine-derived actinomycete Streptomyces sp. G666 led to the isolation of three new shikimic acid derivatives, streptomine A-C (1-3), along with five known compounds (4-8). Their structures were established by their spectral data analyses, including MS and NMR.

Gender Disparities and Their Impact on the Professional Experiences of Female Neurosurgery Residents in Germany: A Cross-Sectional Survey.

Background: Despite advancements in gender equality within neurosurgery, the field continues to encounter challenges related to the under-representation of women and reports of gender-based disparities. This study examines the impact of these disparities on the experiences, professional development, and well-being of female neurosurgery residents in Germany, identifying specific challenges within the neurosurgical community.

Methods: An anonymous, questionnaire-based survey was conducted among female neurosurgery residents from various German training hospitals nationwide, using a quantitative approach.

The utility of Ocimum basilicum, Perilla frutescens, and Mentha spicata essential oils to control larvae and engorged female Rhipicephalus sanguineus ticks on dogs.

The study evaluated the larvicidal and reproductive effects of essential oils from Ocimum basilicum, Perilla frutescens, and Mentha spicata on engorged female Rhipicephalus sanguineus ticks. Adult immersion and larval packet assays were used to evaluate their larvicidal efficacy and impact on tick reproductive abilities. For tick larvae, Perilla frutescens essential oil had the highest 50% lethal dose of 1.

New Cytotoxic Sesquiterpene Lactones from the Leaves of Tithonia Diversifolia and their Apoptosis Effect Evaluation in KB Cancer Cells.

From the leaves of Tithonia diversifolia, nine sesquiterpenoids (1-9), including two new ones (tagitinin J (1) and tagitinin K (2)) were isolated and structurally determined. Their chemical structures were elucidated by extensive analyses of the HRESIMS and NMR spectral data, as well as comparison with the literature. All of the isolated compounds (except compounds 7-9) significantly exhibited cytotoxic activity against four human cancer cell lines (KB, HepG2, A549 and MCF7), with IC values ranging from 0.

Secondary metabolites from marine fungus Penicillium chrysogenum VH17 and their antimicrobial and cytotoxic potential.

One new compound, methyl 3-((1-((2-carbamoylphenyl)amino)-1-oxopropan-2-yl)amino)-3-oxopropanoate (1), along with 9 known secondary metabolites (2-10) were isolated and elucidated chemical structures from the methanol extract of the marine-derived fungus Penicillium chrysogenum VH17. Subsequent bioassays showed the antimicrobial and cytotoxic potential of the isolated compounds. All compounds 1-10 displayed antimicrobial effects against at least one tested reference microorganism with MIC values ranging from 32 to 256 µg mL-1.

Mycology laboratory diagnostic capacity for invasive fungal diseases in public hospitals in Vietnam.

This was a cross-sectional study on the availability of laboratory infrastructure and capacity for the diagnosis of invasive fungal diseases in 24 public hospitals in Vietnam in 2023. Among the hospitals surveyed, 66.7% (14/21) had specialized personnel assigned for mycology testing, and 95.

Challenges and aspirations of neurosurgery residents in Germany: Insights from a questionnaire-based survey.

Objective: Neurosurgery residents in Germany face numerous challenges including receiving comprehensive surgical training with adequate learning opportunities, achieving balanced work life equilibrium, maintaining a positive work environment and navigating career prospects. The objectives of this study are to assess overall satisfaction with the training program, identify factors contributing to dissatisfaction, explore various dimensions of the training program, evaluate the psychological well-being of residents, and ascertain their preferences for future subspecialties.

Methods: A questionnaire-based survey was conducted anonymously among neurosurgery residents from various training hospitals, nationwide.

COVID-19 risk perceptions in Japan: a cross-sectional study.

We conducted a large-scale online survey in February 2023 to investigate the public's perceptions of COVID-19 infection and fatality risks in Japan. We identified two key findings. First, univariate analysis comparing perceived and actual risk suggested overestimation and nonnegligible underestimation of COVID-19 risk.

Sprouted rough rice as an alternative to corn for growth, health performance and meat quality of broilers.

Sprouted rough rice (SR) is not commly used for poultry diets but it could be a potential replacement ingredient to improve nutritional value of feed. This study aimed to evaluate the growth performance, carcass quality, blood lipids, hepatic enzymes, and fatty acid profiles of broiler meat when corn was replaced with sprouted rough rice in the feed. A completely randomized design was used with four groups and six replicate groups with 10 birds per replicate.

Secondhand Smoke and Socio-Demographic Associated Factors: Results From the Vietnam Population-Based Provincial Global Adult Tobacco Survey in 2022.

Secondhand smoke (SHS) has detrimental effects on community health, including coronary heart diseases, stroke, lung cancer etc. This manuscript exploited data from the Vietnam Population-based Provincial Global Adult Tobacco Survey (PGATS) in 2022 to update the prevalence of adult exposure to SHS and associated socio-demographic factors. With the sample size of 71,981 adults aged 15+ throughout 30 provinces and cities in Vietnam, data was collected using the Global Adult Tobacco Survey (GATS) questionnaire.

New -lignans from the leaves of guillaumin.

Phytochemical study of the leaves of Guillaumin resulted in the isolation of a new natural product egonol-3''-sulphate (), and two new derivatives egonol-3-methylD-galactopyranoside () and 7-methoxy-2-(3',4'-methylenedioxyphenyl)-benzofuran-5-carboxamide (). Their chemical structures were -elucidated by spectroscopic data. Compounds and significantly established a great role for the chemotaxonomic aspect.

Factors affecting highly pathogenic avian influenza vaccination practices at poultry farms in Tra Vinh, Vietnam.

Background: The increased number of cases of highly pathogenic avian influenza (HPAI) as a zoonosis has raised concerns in terms of poultry and human health. Farmers' preventive practices are an effective way of reducing zoonosis. However, this practice may have been affected by many factors, including production behaviors, awareness, and farmers' perceptions of farmers toward zoonosis.

Identification and nitric oxide production inhibitory activity of phenolic derivatives from the trunks of .

Phytochemical investigation of the trunks from led to the isolation of a novel phenolic glucoside, 2-2,4-di-(3,4-dihydroxyphenyl)but-2-en-1-yl---D-glucopyranoside (), along with five known stilbene derivatives (). Their structures were determined mainly using high-resolution electrospray ionisation mass spectrometry and nuclear magnetic resonance spectroscopic analyses, followed by comparisons of observed spectral data with reported values. The novel compound in was found to be useful as a chemotaxonomic marker.

Effect of ambient air pollution on hospital admission for respiratory diseases in Hanoi children during 2007-2019.

Air pollution poses a threat to children's respiratory health. This study aims to quantify the association between short-term air pollution exposure and respiratory hospital admissions among children in Hanoi, Vietnam, and estimate the population-attributable burden using local data. A case-crossover analysis was conducted based on the individual records where each case is their own control.

Two new flavonoids with antimicrobial activity from the roots of Colebr. ex Wall (Malvaceae).

Two new flavonoids, 4',5,7-trihydroxy-5'-methoxy-6,8-dimethylisoflavone () and 2',5',7-trihydroxy-5-methoxy-6,8-dimethylflavanone () together with the known flavonoids 4´,5,7-trihydroxy-3´-methoxy-6.8-dimethylflavone (), epigallocatechin (), 4´-O-methylepicatechin () and quercetin () were isolated from the roots of . The structures of these compounds were determined by means of spectroscopic methods.

Individual-, social- and policy- factors associated with smoking cessation among adult male cigarette smokers in Hanoi, Vietnam: a longitudinal study.

Background: Nearly one-in-two Vietnamese men smoke cigarettes placing them among the highest tobacco consumers in the world. Despite the need for smoking cessation to curb the burden of tobacco-related diseases in Vietnam, this rate remains at less than 30%. Therefore, this study examines individual-, social- and policy factors associated with smoking cessation among adult male smokers in Vietnam.

Oleanane-type triterpenoid sulphates, two new α-glucosidase inhibitors from .

In connection with our interest in the phytochemical investigation of Oliv. (Elaeocarpaceae) growing in Vietnam, two new sulphated oleanane triterpenes were obtained herein and structurally identified. Based on the combination of the extensive 1D-, 2D NMR and HR ESI MS spectroscopic data analysis, their chemical structures have been elucidated as 1,3-dihydroxy-olean-18-ene 1-sulphate () and 1,3-dihydroxy-olean-12-ene 1-sulphate ().

Drought-Stress-Related Reprogramming of Gene Expression in Barley Involves Differential Histone Modifications at ABA-Related Genes.

Plants respond to drought by the major reprogramming of gene expression, enabling the plant to survive this threatening environmental condition. The phytohormone abscisic acid (ABA) serves as a crucial upstream signal, inducing this multifaceted process. This report investigated the drought response in barley plants (, cv.

Effects of dietary β-glucan and rice fermented on growth performance, fatty acids, and Newcastle disease immune response in turkey broilers.

Poultry production has been developing in Vietnam with challenges of disease. Thus, feed additive should be investigated not only growth but also health enhancement. Here, we aimed to determine the effects of -fermented rice (FR) and β-glucan on turkey's growth performance, carcass characteristics, immune and fatty acid (FA) profiles.

Smoking Cessation, Quit Attempts and Predictive Factors among Vietnamese Adults in 2020.

Objective: This study aims to describe the updated smoking cessation and quit attempt rates and associated factors among Vietnamese adults in 2020.

Methods: Data on tobacco use among adults in Vietnam in 2020 was derived from the Provincial Global Adult Tobacco Survey. The participants in the study were people aged 15 and older.