Expanding Radical Chloropentafluorosulfanylation of Alkynes.

The chloropentafluorosulfanylation of alkynes is a delicate but crucial operation for accessing SF-alkynes that serve as substrates in numerous transformations. Dolbier's procedure using EtB/O was the most efficient approach, while recent efforts make use of other initiators and light activation. We found that THF, as a single stimulus, is sufficient to trigger the reaction of SFCl with alkynes.

Tracking SF I in the Iodopentafluorosulfanylation of Alkynes.

In the vibrant field of SF chemistry, SF X reagents (X=F, Cl, Br) are at the heart of current investigations in radical pentafluorosulfanylation reactions. SF I is the missing link whose existence has not been reported despite its potential as SF donor. This study reports the formal addition of the hitherto unknown SF I reagent to alkynes by means of a combination of SF Cl/KI/18-crown-6 ether.

Iridium-Catalyzed Direct Reductive Amination of Ketones and Secondary Amines: Breaking the Aliphatic Wall.

Invited for the cover of this issue are Matthieu Jouffroy from Discovery Process Research at Janssen Pharmaceutica N.V. and the group of Rafael Gramage-Doria at the University of Rennes.

Whether planar or corrugated graphitic carbon nitride combined with titanium dioxide exhibits better photocatalytic performance?

The density functional theory method was performed to study the electronic structures of planar (pGN), corrugated (cGN) graphitic carbon nitride and their interactions with titanium dioxide cluster (TiO). The transfer of photoinduced electrons was analyzed and electronic excitations were calculated. The obtained results show that cGN is thermodynamically more stable than pGN.

Iridium-Catalyzed Direct Reductive Amination of Ketones and Secondary Amines: Breaking the Aliphatic Wall.

Direct reductive amination (DRA) is a ubiquitous reaction in organic chemistry. This transformation between a carbonyl group and an amine is most often achieved by using a super stoichiometric amount of hazardous hydride reagents, thus being incompatible with many sensitive functional groups. DRA could also be achieved by means of chemo- or biocatalysis, thereby attracting the interest of industry as well as academic laboratories due to the virtually perfect atom economy.

Access to [2,1]Benzothiazine ,-Dioxides from β-Substituted -Nitrostyrenes and Sulfur.

[2,1]Benzothiazine ,-dioxides were synthesized by simply heating -nitrostyrenes with elemental sulfur in 3-picoline with complete atom economy. This reaction was found to occur without any added catalyst and consist of a cascade of reduction of the nitro group, sulfuration of a C-H of the double bond, oxidation of a sulfur atom to its highest oxidation state by the migration of two oxygen atoms from the nitro group, and formation of new N-S bonds. Furthermore, the method could also be applied to -nitrocinnamamides and cinnamate esters.

Transport and bioaccumulation of polychlorinated dibenzo-p-dioxins and dibenzofurans at the Bien Hoa Agent Orange hotspot in Vietnam.

The Bien Hoa airbase (south of Vietnam) is known as one of the Agent Orange hotspots which have been seriously contaminated by Agent Orange/dioxin during the Vietnam War. Hundreds of samples including soil, sediment and fish were collected at the Bien Hoa Agent Orange hotspot for assessment of the environmental contamination caused by dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs). The toxicity equivalency quotient (TEQ) concentration of PCDD/Fs in soil and sediment varied from 7.