Temperature Dependence of Optical Properties of MoS and WS Heterostructures Assessed by Spectroscopic Ellipsometry.

We report the complex dielectric function = + of MoS/WS and WS/MoS heterostructures and their constituent monolayers MoS and WS for an energy range from 1.5 to 6.0 eV and temperatures from 39 to 300 K.

Stability and magnetic properties of transition metal (V, Cr, Mn, and Fe) doped cobalt oxide clusters: a density functional theory investigation.

Co TMO ( = 6-8), (TM = V, Cr, Mn, and Fe) clusters are investigated using density functional theory calculations. The transition metal atoms preferentially replace one Co atom at sites where the number of metal-oxygen bonds is maximized, forming more stable structures. The evaporation of a Co atom is the most fragile dissociation channel for both pure and doped species.

Suaedamas A-D: Four New Compounds from the Aerial Parts of Suaeda maritima with Inhibition of NO Production Activity.

Four new compounds, suaedamas A-D (1-4), and seven known ones (5-11) were isolated from the aerial parts of Suaeda maritima. Their chemical structures were evaluated by the IR, HR-ESI-MS, 1D-, and 2D-NMR, experimental and calculated ECD spectra. Compounds 1-6 inhibited nitric oxide production in LPS activated RAW 264.

Unraveling Hydrogen Adsorption on Transition Metal-Doped [MoS] Clusters: Insights from Density Functional Theory Calculations.

Molecular and dissociative hydrogen adsorption of transition metal (TM)-doped [MoS] atomic clusters were investigated using density functional theory calculations. The introduced TM dopants form stable bonds with S atoms, preserving the geometric structure. The S-TM-S bridging bond emerges as the most stable configuration.

Oleanane-Type Triterpene Glycosides from Camellia phanii and Their α-Glucosidase Inhibitory Activity.

Three new oleanane-type triterpene saponins, named camphanosides A-C (1-3), along with five known compounds, chikusetsusaponin IVa (4), spinasaponin A 28-O-glucoside (5), (-)-epicatechin (6), (-)-epicatechin 3-O-gallate (7), and (-)-epigallocatechin 3-O-gallate (8) were isolated from the leaves Camellia phanii Hakoda & Ninh. Their structures were established by 1D and 2D-NMR and mass spectral analysis and chemical methods. Moreover, compounds 1-5 were also evaluated for α-glucosidase inhibitory activity.

Haemophilia care in Asia: Learning from clinical practice in some Asian countries.

Background: The healthcare systems in Asia vary greatly due to the socio-economic and cultural diversities which impact haemophilia management.

Methods: An advisory board meeting was conducted with experts in haemophilia care from Asia to understand the heterogeneity in clinical practices and care provision in the region.

Findings: The overall prevalence of haemophilia in Asia ranges between 3 and 8.

High-yield BMP2 expression in rice cells via CRISPR and endogenous αAmy3 promoter.

Plant cells serve as versatile platforms for the production of high-value recombinant proteins. This study explored the efficacy of utilizing an endogenous αAmy3 promoter for the expression of a bioactive pharmaceutical protein, specifically the mature region of human bone morphogenetic protein 2 (hBMP2m). Utilizing a refined CRISPR/Cas9-mediated intron-targeting insertion technique, which incorporates an artificial 3' splicing site upstream of the target gene, we achieved a transformation efficiency of 13.

Four Undescribed compounds Isolated from the Aerial Parts of Phyllanthus cochinchinensis with Antimicrobial Activity and NO Production Inhibitory Activity in LPS Activated RAW 264.7 Cells.

Four previously undescribed compounds named phyllancosides A and B (1 and 2), and phyllancochines A and B (3 and 4) together with ten known compounds (5-14) were isolated from the aerial parts of Phyllanthus cochinchinensis Spreng. Their chemical structures were elucidated on the basis of comprehensive analysis of IR, HR-ESI-MS, 1D and 2D NMR spectra. The absolute configurations of 1 and 2 were determined by electronic circular dichroism (ECD) spectra.

Robust preimplantation genetic testing of the common F8 Inv22 pathogenic variant of severe hemophilia A using a highly polymorphic multi-marker panel encompassing the paracentric inversion.

Background: Hemophilia A (HEMA) is an X-linked bleeding disorder caused by reduced/absent coagulation factor VIII expression, as a result of pathogenic variants in the F8 gene. Preimplantation prevention of HEMA should ideally include direct pathogenic F8 variant detection, complemented by linkage analysis of flanking markers to identify the high-risk F8 allele. Linkage analysis is particularly indispensable when the pathogenic variant cannot be detected directly or identified.

Escalating Catalytic Activity for Hydrogen Evolution Reaction on MoSe@Graphene Functionalization.

Developing highly efficient and durable hydrogen evolution reaction (HER) electrocatalysts is crucial for addressing the energy and environmental challenges. Among the 2D-layered chalcogenides, MoSe possesses superior features for HER catalysis. The attractions and high surface energy, however, stack the MoSe layers, resulting in a loss of edge active catalytic sites.

Four New Flavonoid C-Glycosides Isolated from Achyranthes aspera and Their Nitric Oxide Production Inhibitory Activities.

A chemical study of the methanol extract of the aerial parts of Achyranthes aspera led to the isolation of four new flavonoid C-glycosides (1-4) along with eight known analogs (5-12). Their structures were elucidated by a combination of spectroscopic data analysis, HR-ESI-MS, 1D and 2D NMR spectra. All the isolates were evaluated their NO production inhibitory activity in LPS-activated RAW264.

Two new lignan glycosides from L. with their NO inhibition and cytotoxic activity.

A phytochemical investigation of the methanolic extract of aerial parts of the led to the isolation of two new lignan glycosides, acaniliciosides A and B ( and ), together with ten known compounds (-). The structures of isolated compounds were elucidated based on HR-ESI-MS, 1D and 2D NMR spectroscopic data. The absolute configurations of two new compounds were established by CD spectra.

Ultrasonic-assisted synthesis of magnetic recyclable FeO/rice husk biochar based photocatalysts for ciprofloxacin photodegradation in aqueous solution.

In this work, a new facile one-spot method has been designed to fabricate a magnetic recyclable FeO/rice husk biochar photocatalyst (FBP) for the removal of Ciprofloxacin (CIP) in aqueous solution. This method combines ultrasonic-assisted impregnation and precipitation, which can overcome the difficulties of long-time reactions, complex procedures, and extreme condition requirements. The successful fabrication of the FeO/biochar material has been proven by a series of material characterization techniques, including X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Raman, Fourier Transform Infrared Spectroscopy (FTIR), X-ray Photoelectron Spectroscopy (XPS), and vibrating sample magnetometer (VSM).

Green and Facile Synthesis of Porous SiO@C Adsorbents from Rice Husk: Preparation, Characterization, and Their Application in Removal of Reactive Red 120 in Aqueous Solution.

In this work, a green, novel, fast, and facile approach for synthesizing a SiO/C nanocomposite series from rice husk (RH) through quenching and grinding techniques has been reported along with its application for the adsorptive removal of Reactive Red 120 (RR120) dye from an aqueous solution. The effect of carbonization temperature on the textural and interfacial features of RH was confirmed by scanning electron microscopy (SEM), while the structure and elemental composition of the as-synthesized RH were investigated via XRD, Brunauer-Emmett-Teller (BET), FT-IR, Raman, and X-ray photoelectron spectroscopy (XPS). The RH had a high surface area (521.

Immunomodulatory effects of graded levels of docosahexaenoic acid (DHA) in common carp (Cyprinus carpio) - In vitro and in vivo approaches.

The D-series resolvins formed from docosahexaenoic acid (DHA) work as anti-inflammatory mediators indicating the role of this long-chain polyunsaturated fatty acid in the immune system of mammals. However, such information is still limited in fish. The current study was conducted to evaluate the immunomodulatory effects of graded levels of DHA in common carp Cyprinus carpio by in vitro and in vivo approaches.

Achyranbidens A-C: three new compounds from Blume.

Phytochemical study on the roots of Blume led to the isolation of sixteen compounds including three new ones (). Their chemical structures were determined as oleanolic acid 28---D-glucopyranoside-3--[-D-glucopyranosyl-(1→3)--D-galactopyranoside) (), methyl (8,11)-5,6,7-trihydroxytetradeca-8,11-dienoate (), methyl (6,11)-5,8,9-trihydroxytetradeca-6,11-dienoate (), fulgidic acid (), (9,11)-13-oxooctadeca-9,11-dienoic acid (), (9,11,15)-13-hydroxyoctadeca-9,11,15-trienoic acid (), oleanolic acid 28---D-glucopyranoside-3---L-rhamnopyranosyl-(1→4)--D-glucuronopyranoside (), oleanolic acid 28---D-glucopyranoside-3---Dglucopyranosyl-(1→2)-[-L-rhamnopyranosyl-(1→3)]--D-glucuronopyranoside (), oleanolic acid 3---Dglucopyranosyl-(1→2)-[-L-rhamnopyranosyl-(1→3)]--D-glucuronopyranoside (), oleanolic acid 3---L-rhamnopyranosyl-(1→3)--D-glucuronopyranoside (), blumenol C glucoside (), citroside A (), 6,9-roseoside (), ginsenoside Rg1 (), 20-hydroxyecdysone (), and benzyl -L-rhamnopyranosyl-(1→6)]--D-glucopyranoside () by spectroscopic analysis. Compounds , and inhibited NO production in LPS-activated RAW264.

Preimplantation genetic testing (PGT) for hemophilia A: Experience from one center.

Objective: Hemophilia A (HA) is an X-linked recessive bleeding disease caused by a deficiency or dysfunction of blood coagulation factor VIII (FVIII). Available treatment to replenish the missing factor may not reach a good outcome for all patients because of potential complications that include the development of inhibitor antibodies directed against factor VIII. Therefore, the prevention of transmitting pathogenic mutations to the next generation is the best solution for this disease.

Density Functional Study of Size-Dependent Hydrogen Adsorption on Ag Cr ( = 1-12) Clusters.

Increasing interest has been paid for hydrogen adsorption on atomically controlled nanoalloys due to their potential applications in catalytic processes and energy storage. In this work, we investigate the interaction of H with small-sized Ag Cr ( = 1-12) using density functional theory calculations. It is found that the cluster structures are preserved during the adsorption of H either molecularly or dissociatively.

Constituents of and their nitric oxide inhibitory activities.

One new phenylpropanoid glycoside, tinosinen A () and 13 known compounds, tinosinen (), citrusin B (), picraquassioside C (), -guaiacylglycerol---4'-coniferyl alcohol (), -guaiacylglycerol-8--4'-(sinapyl alcohol) ether (), -syringylglycerol-8--4'-(sinapyl alcohol) ether (), -isolariciresinol 9--D--glucopyranoside (), tinosposide A (), pinoresinol-4'--D-glucopyranoside (), syringaresinol-4'---D-glucopyranoside (), pinoresinol (), syringaresinol (), and lirioresino--dimethyl ether () were isolated from the stems of (Lour.) Merr. Their structures were established by detailed spectroscopic studies and comparisons with those reported in the literature.

Intestinal histopathology and immune responses following Escherichia coli lipopolysaccharide challenge in Nile tilapia fed enriched black soldier fly larval (BSF) meal supplemented with chitinase.

This study aimed to determine to what extend the addition of chitinase to black soldier fly larvae (BSF) meals enriched with either PUFA or LC-PUFA could improve the gut health of Nile tilapia and increase its immune status. Two types of BSF meals enriched with either α-linolenic acid (ALA) or ALA + eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) were produced using BSF larvae cultured on vegetable substrates (VGS) or fish offal substrates (FOS), respectively. Seven diets were formulated: a control FMFO diet and two other control diets VGD0 vs FOD0 containing the meals of each type of BSF meal as total replacement for fishmeal (FM) and fish oil (FO), as well as four diets supplemented with chitinase.

One new furostane saponin from and lipid accumulation inhibitory activity.

A new furostane saponin, ramosaponin (), and four known furostane saponins, protodioscin (), dehydrotomatoside (), (25 )-26--(-D-glucopyranosyl)-furost-5-ene-3,22,26-triol 3---D-glucopyranosyl-(1→4)--D-galactopyranoside (), and anguivioside A () were isolated from the methanol extract of seeds. Their structures were identified based on spectroscopic evidence and comparison with those reported in the literature. All compounds were evaluated for reduction of lipid accumulation in HepG2 cell line.

Predicting High Blood Pressure Using DNA Methylome-Based Machine Learning Models.

DNA methylation modification plays a vital role in the pathophysiology of high blood pressure (BP). Herein, we applied three machine learning (ML) algorithms including deep learning (DL), support vector machine, and random forest for detecting high BP using DNA methylome data. Peripheral blood samples of 50 elderly individuals were collected three times at three visits for DNA methylome profiling.

A computationally affordable approach for accurate prediction of the binding affinity of JAK2 inhibitors.

Janus kinase 2 (JAK2) inhibitors are potential anticancer drugs in the treatment of lymphoma, leukemia, thrombocytosis and particularly myeloproliferative diseases. However, the resemblance among JAK family members has challenged the identification of highly selective inhibitors for JAK2 to reduce undesired side effects. As a result, a robust search for promising JAK2 inhibitors using a computational approach that can effectively nominate new potential candidates to be further analyzed through laborious experimental operations has become necessary.