The association of magnetic resonance imaging features with five molecular subtypes of breast cancer.

Objective: To identify the association of magnetic resonance imaging (MRI) features with molecular subtypes of breast cancer (BC).

Materials And Methods: A retrospective study was conducted on 112 invasive BC patients with preoperative breast MRI. The confirmed diagnosis and molecular subtypes of BC were based on the postoperative specimens.

Structure based innovative approach to analyze aptaprobe-GPC3 complexes in hepatocellular carcinoma.

Background: Glypican-3 (GPC3), a membrane-bound heparan sulfate proteoglycan, is a biomarker of hepatocellular carcinoma (HCC) progression. Aptamers specifically binding to target biomolecules have recently emerged as clinical disease diagnosis targets. Here, we describe 3D structure-based aptaprobe platforms for detecting GPC3, such as aptablotting, aptaprobe-based sandwich assay (ALISA), and aptaprobe-based imaging analysis.