The effect of autologous demineralized dentin matrix on postoperative complications and wound healing following lower third molar surgery: A split-mouth randomized clinical trial.

Background/purpose: Autologous dentin materials are among the most promising bone substitutes for preventing osseous defects on the distal side of the lower second molar. This study aimed to investigate the effects of autologous demineralized dentin matrix on postoperative complications and wound healing after lower third molar surgery.

Materials And Methods: Thirteen patients with bilateral symmetrical lower third molars participated in this split-mouth randomized clinical trial.

Cognitive component of auditory attention to natural speech events.

The recent progress in auditory attention decoding (AAD) methods is based on algorithms that find a relation between the audio envelope and the neurophysiological response. The most popular approach is based on the reconstruction of the audio envelope from electroencephalogram (EEG) signals. These methods are primarily based on the exogenous response driven by the physical characteristics of the stimuli.

In Vitro Biological Evaluation and In Silico Studies of a New Anthraquinone From Zingiber Cassumunar Roxb. in Type 2 Diabetes Management.

A novel diphenyl-anthraquinone compound, cassuquinone A (CA), was isolated from the rhizomes of Zingiber cassumunar. Structural elucidation was accomplished using detailed nuclear magnetic resonance and high-resolution mass spectroscopy-electrospray ionization techniques, revealing a symmetrical anthraquinone core with methoxylated aromatic rings. CA exhibited potent α-glucosidase (AR) inhibitory activity with an IC₅₀ of 11.

Assessment of the Performance of the Dose Calibrator Used in Radioactivity Measurement.

Aims: This study aimed to evaluate the principal technical characteristics of a well-type gas-filled ionization chamber dose calibrator used in measuring radiopharmaceutical activity, namely accuracy, repeatability, and linearity. Furthermore, this work also explored the correlation between the device's response and the position and volume of the radiopharmaceutical I-131.

Materials And Methods: Experimental measurements were conducted on the ATOMLAB 500 dose calibrator using NIST traceable Cs-137 source to determine the accuracy and repeatability.

Immune regulatory adjuvant approach to mitigate subcutaneous immunogenicity of monoclonal antibodies.

Introduction: Immunogenicity continues to be a challenge for development and clinical utility of monoclonal antibodies, and there are gaps in our current ability to prevent anti-drug antibody development in a safe and antigen-specific manner.

Methods: To mitigate immunogenicity of monoclonal antibodies administered subcutaneously, O-phospho-L-serine (OPLS)-the head group of the tolerance-inducing phospholipid, phosphatidylserine-was investigated as an immunoregulatory adjuvant.

Results: Formulations of adalimumab, trastuzumab or rituximab with OPLS showed reduction in relative immunogenicity in mice compared to vehicle formulations, indicated by reduced anti-drug antibody development and significant reductions in CD138+ plasma cell differentiation in bone marrow.

Phased Array Antenna Calibration Based on Autocorrelation Algorithm.

The problem of calibrating phased array antennas in a noisy environment using an autocorrelation algorithm is investigated and a mathematical model of the autocorrelation calibration method is presented. The proposed calibration system is based on far-field scanning of the phased array antenna in an environment with internal noise and external interference. The proposed method is applied to a phased array antenna and compared with traditional rotating-element electric-field vector methods, which involve identifying the maximum and minimum vector-sum points (REVmax and REVmin, respectively).

ProteinReDiff: Complex-based ligand-binding proteins redesign by equivariant diffusion-based generative models.

Proteins, serving as the fundamental architects of biological processes, interact with ligands to perform a myriad of functions essential for life. Designing functional ligand-binding proteins is pivotal for advancing drug development and enhancing therapeutic efficacy. In this study, we introduce ProteinReDiff, an diffusion framework targeting the redesign of ligand-binding proteins.

ISG15 Drives Immune Pathology and Respiratory Failure during Systemic Lymphocytic Choriomeningitis Virus Infection.

ISG15, an IFN-stimulated gene, plays a crucial role in modulating immune responses during viral infections. Its upregulation is part of the host's defense mechanism against viruses, contributing to the antiviral state of cells. However, altered ISG15 expression can also lead to immune dysregulation and pathological outcomes, particularly during persistent viral infections.

Three undescribed phenylbutenoids derivatives from Roxb. rhizomes and their biological activities.

Phenylbutenoids belong to polyphenolic compounds that have demonstrated distinctive biological activities and are primarily characterised in the genus Zingiber (Zingiberaceae) species. From the EtOAc extract of the rhizomes of Roxb., three phenylbutenoid-type compounds, cassudimin B (), cassumunol O (), and cassumunol P (), were isolated, along with five known compounds (-).

Rating pome fruit quality traits using deep learning and image processing.

Quality assessment of pome fruits (i.e. apples and pears) is used not only for determining the optimal harvest time but also for the progression of fruit-quality attributes during storage.

Systemic dysregulation and molecular insights into poor influenza vaccine response in the aging population.

Vaccination-induced protection against influenza is greatly diminished and increasingly heterogeneous with age. We investigated longitudinally (up to five time points) a cohort of 234 vaccinated >65-year-old vaccinees with adjuvanted vaccine FluAd across two independent seasons. System-level analyses of multiomics datasets measuring six modalities and serological data revealed that poor responders lacked time-dependent changes in response to vaccination as observed in responders, suggestive of systemic dysregulation in poor responders.

Gα13 controls pharyngeal endoderm convergence by regulating E-cadherin expression and RhoA activation.

Pharyngeal endoderm cells undergo convergence and extension (C&E), which is essential for endoderm pouch formation and craniofacial development. Our previous work implicates Gα13/RhoA-mediated signaling in regulating this process, but the underlying mechanisms remain unclear. Here, we have used endoderm-specific transgenic and Gα13 mutant zebrafish to demonstrate that Gα13 plays a crucial role in pharyngeal endoderm C&E by regulating RhoA activation and E-cadherin expression.

Factors predicting menstrual irregularity among university students in Ho Chi Minh City, Vietnam: A cross-sectional study.

Background: University students often face menstrual irregularities, particularly among healthcare students, due to rigorous study environments, such as night duties resembling professional staff responsibilities.

Objective: This study aimed to examine the prevalence of and factors predicting menstrual irregularities among female students in Ho Chi Minh City, Vietnam.

Methods: A cross-sectional study was conducted from April to July 2023 at the University of Medicine and Pharmacy at Ho Chi Minh City (UMP).

Pregnancy in Infertile Patient after Intrauterine Adhesiolysis by Multitherapeutic Strategy: A Case Report and Mini-review.

Asherman's syndrome, characterized by intrauterine adhesions (IUAs), represents a significant challenge in the field of female infertility. Hysteroscopic adhesiolysis has emerged as the gold standard for both the diagnosis and treatment of Asherman's syndrome. Understanding the intricate relationship between Asherman's syndrome, uterine adhesiolysis, and infertility is crucial for guiding comprehensive and effective management strategies.

Financial toxicity in patients with cancer: a cross-sectional study at an oncology hospital in central Vietnam.

Purpose: Cancer imposes a substantial financial burden on patients because of the high out-of-pocket expenses and the significant hardships. Financial toxicity describes the impact of cancer care costs at the patient level. Although the financial impact of cancer has been recognized, understanding the extent and determinants of financial toxicity in specific contexts is crucial.

Mitochondrial DNA variants correlate with a primary open-angle glaucoma subgroup.

Introduction: Primary open-angle glaucoma (POAG) is a characteristic optic neuropathy, caused by degeneration of the optic nerve-forming neurons, the retinal ganglion cells (RGCs). High intraocular pressure (IOP) and aging have been identified as major risk factors; yet the POAG pathophysiology is not fully understood. Since RGCs have high energy requirements, mitochondrial dysfunction may put the survivability of RGCs at risk.

Airway basal stem cells are necessary for the maintenance of functional intraepithelial airway macrophages.

Adult stem cells play a crucial role in tissue homeostasis and repair through multiple mechanisms. In addition to being able to replace aged or damaged cells, stem cells provide signals that contribute to the maintenance and function of neighboring cells. In the lung, airway basal stem cells also produce cytokines and chemokines in response to inhaled irritants, allergens, and pathogens, which affect specific immune cell populations and shape the nature of the immune response.

Evaluation of transfusion reactions in patients following transfusion of blood components containing antibodies to HLA class I - An attempt to prevent TRALI in patients.

In an attempt to mitigate transfusion-related acute lung injury (TRALI), the Oslo Blood Center screened 1369 thrombapheresis donors for human leucocyte antigen (HLA)-specific antibodies. Anti-HLA antibodies were found in 200 donors who were deferred from donation of plasma-rich products. In a retrospective study, 2562 transfusions of thrombocytes (both apheresis and whole blood-derived) from 150 of these donors were subject to a thorough look back-investigation.

Discovery of Alkyl Triphenylphosphonium Pinostrobin Derivatives as Potent Anti-Breast Cancer Agents.

Pinostrobin demonstrated anticancer properties, but its hydrophobic feature led to a reduction in bioavailability. The mitochondria-targeted approach successfully synthesized eight new alkyl triphenylphosphonium pinostrobin derivatives (1-8) with good yield in this study. Seven compounds (1-3, 5-8) showed greater cytotoxic potency against the human MCF-7 breast cancer cell line than pinostrobin.

biological evaluation and studies of linear diarylheptanoids from Salisb. as urease inhibitors.

Plants of the family, specifically those belonging to the species, are commonly under consideration as potential therapeutic agents for the management of gastrointestinal diseases. In this study, we carried out a phytochemical study on Salisb. (or so-called "Nghe trang" in Vietnamese) grown in Vietnam, which yields three newly discovered 3,5-diacetoxy diarylheptanoids (1-3) and six known 3,5-dihydroxyl diarylheptanoids (4-9).

Study on the concentration, composition, and recovery rate of bacterial bioaerosols after rainfall in Ho Chi Minh City.

Aerosolized microorganisms have become an important factor in assessing air quality. To determine the characteristics of bacterial bioaerosols in air and rainwater, as well as calculate the recovery rate of bacteria after rains in Ho Chi Minh City, our study was performed using the SKC Biostage sampler for airborne bacteria and Plate Count Agar (PCA) medium for bacterial concentration. Subsequently, the study determined the bacterial community composition at the phylum and order levels using the 16S rRNA (16S metabarcoding) method.

Generation of parthenocarpic tomato plants in multiple elite cultivars using the CRISPR/Cas9 system.

Unlabelled: Tomato ( L.) is one of the most important crops in the world for its fruit production. Advances in cutting-edge techniques have enabled the development of numerous critical traits related to the quality and quantity of tomatoes.