Facile Ru-catalysed synthesis of quinazolin-4(3)-ones by tandem cyclization of 2-nitrobenzonitrile and alcohol derivatives under air.

We have developed an efficient approach for the first Ru-catalysed synthesis of 2-arylquinazolin-4(3)-ones from 2-nitrobenzonitriles and alcohols. This method features a broad substrate scope, high yields, and functional group tolerance and does not require any oxidant or reductant, allowing for simple, practical and sustainable synthesis.

Alchemical approach performance in calculating the ligand-binding free energy.

Alchemical binding free energy calculations are one of the most accurate methods for estimating ligand-binding affinity. Assessing the accuracy of the approach over protein targets is one of the most interesting issues. The free energy difference of binding between a protein and a ligand was calculated the alchemical approach.

Orally ingestible medication utilizing layered double hydroxide nanoparticles strengthened alginate and hyaluronic acid-based hydrogel bead for bowel disease management.

In the treatment of bowel diseases such as ulcerative colitis through oral administration, an effective drug delivery system targeting the colon is crucial for enhancing efficacy and minimizing side effects of therapeutic agents. This study focuses on the development of a novel nanocomposite hydrogel bead comprising a synergistic blend of biological macromolecules, namely sodium alginate (ALG) and hyaluronic acid (HA), reinforced with layered double hydroxide nanoparticles (LDHs) for the oral delivery of dual therapeutics. The synthesized hydrogel bead exhibits significantly enhanced gel strength and controllable release of methylprednisolone (MP) and curcumin (CUR), serving as an anti-inflammatory drug and a mucosal healing agent, compared to native ALG or ALG/HA hydrogel beads without LDHs.

A Vulvovaginal Yeast Infection Caused by in Vietnam: A Rare Case Report.

Cases of vulvovaginitis caused by genus are exceedingly uncommon, with only a handful of instances having been described for this causative species. This report describes a rare case of vulvovaginitis suspected to be caused by in a 58-year-old woman residing in an urban area of Hanoi city, Vietnam. The patient with a 10-year history of depression and type 2 diabetes mellitus was admitted to the hospital due to vulvar itching and vaginal discharge.

Anti-inflammatory and Antiphytopathogenic Fungal Activity of 2,3--Tirucallane Triterpenoids Meliadubins A and B from Cav. Barks with ChemGPS-NP and In Silico Prediction.

Two new rearranged 2,3--tirucallane triterpenoids, meliadubins A () and B (), along with four known compounds, -, were isolated from the barks of Cav. Compound exhibited a significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC at 5.54 ± 0.

Promoting High-Oxidation-State Metal Active Sites in a Hollow Ternary Metal Fluoride Nanoflake Array for Urea Electrolysis.

The adsorption ability of hydrogen, hydroxide, and oxygenic intermediates plays a crucial role in electrochemical water splitting. Electron-deficient metal-active sites can prompt electrocatalytic activity by improving the adsorption ability of intermediates. However, it remains a significant challenge to synthesize highly abundant and stable electron-deficient metal-active site electrocatalysts.

Crystallization Pathways and Evolution of Morphologies and Structural Defects of α-MnO under Air Annealing.

Manganese dioxide nanomaterials have wide applications in many areas from catalysis and Li-ion batteries to gas sensing. Understanding the crystallization pathways, morphologies, and formation of defects in their structure is particularly important but still a challenging issue. Herein, we employed an arsenal of X-ray diffraction (XRD), scanning electron microscopy (SEM), neutron diffraction, positron annihilation spectroscopies, and calculations to investigate the evolution of the morphology and structure of α-MnO nanomaterials prepared via reduction of KMnO solution with CHOH prior to being annealed in air at 200-600 °C.

Tumour microbiomes and Fusobacterium genomics in Vietnamese colorectal cancer patients.

Perturbations in the gut microbiome have been associated with colorectal cancer (CRC), with the colonic overabundance of Fusobacterium nucleatum shown as the most consistent marker. Despite its significance in the promotion of CRC, genomic studies of Fusobacterium is limited. We enrolled 43 Vietnamese CRC patients and 25 participants with non-cancerous colorectal polyps to study the colonic microbiomes and genomic diversity of Fusobacterium in this population, using a combination of 16S rRNA gene profiling, anaerobic microbiology, and whole genome analysis.

Role of Polyoxometalate Contents in Polypyrrole: Linear Actuation and Energy Storage.

A combination of polyoxometalates with polypyrrole is introduced in this work. Our goal was to include phosphotungstic acid (PTA) in different molar concentrations (0.005, 0.

Isolation and optimization of a glyphosate-degrading Rhodococcus soli G41 for bioremediation.

A widely used herbicide for controlling weeds, glyphosate, is causing environmental pollution. It is necessary to remove it from environment using a cost-effective and eco-friendly method. The aims of this study were to isolate glyphosate-degrading bacteria and to optimize their degradative conditions required for bioremediation.

Gut Mucosal Microbiome Is Perturbed in Rheumatoid Arthritis Mice and Partly Restored after TDAG8 Deficiency or Suppression by Salicylanilide Derivative.

Rheumatoid arthritis (RA), an autoimmune disease, is characterized by chronic joint inflammation and pain. We previously found that the deletion of T-cell death-associated gene 8 (TDAG8) significantly reduces disease severity and pain in RA mice. Whether it is by modulating gut microbiota remains unclear.

Inhibition of α-Glucosidase, Acetylcholinesterase, and Nitric Oxide Production by Phytochemicals Isolated from -In Vitro and Molecular Docking Studies.

The phytochemical constituents from the roots of were investigated by chromatographic isolation, and their chemical structures were characterized using the MS and NMR spectroscopic methods. A total of 10 compounds, including six triterpenoids, two flavonoids, and two phenolic compounds, were identified from the roots of . Out of the isolated compounds, eight showed inhibitory effects on NO production in lipopolysaccharide (LPS)-stimulated RAW 264.

Chemical Composition Analysis and Antioxidant Activity of Monofloral Honeys from Vietnam.

Monofloral honey samples () from Vietnam were determined for their chemical compositions. This is the first report on the chemical composition and antioxidant activity of coffee honey from Vietnam. These samples were characterized by their high contents of total and reducing sugars, total phenolic contents, and total flavonoid contents.

Polypyrrole Polyethylene Composite for Controllable Linear Actuators in Different Organic Electrolytes.

Controllable linear actuation of polypyrrole (PPy) is the envisaged goal where only one ion dominates direction (here anions) in reversible redox cycles. PPy with polyethylene oxide (PEO) doped with dodecylbenzenesulfonate forms PPy-PEO/DBS films (PPy-PEO), which are applied in propylene carbonate (PC) solvent with electrolytes such as 1-ethyl-2,3-dimethylimidazolium trifluoromethanesulfonate (EDMICFSO), sodium perchlorate (NaClO) and tetrabutylammonium hexafluorophosphate (TBAPF) and compared in their linear actuation properties with pristine PPy/DBS samples. PPy-PEO showed for all applied electrolytes that only expansion at oxidation appeared in cyclic voltammetric studies, while pristine PPy/DBS had mixed-ion actuation in all electrolytes.

Constituents from the Fruiting Bodies of and in Vietnam and Their Anti-Inflammatory Bioactivity.

It is reported that various fungi have been used for medicine and edible foods. The tropical genus is popular and well-known in Vietnam for its health effects and bioactivities. In this study, the fruiting bodies of the edible fungi and were collected in Vietnam.

Steel slag quality control for road construction aggregates and its environmental impact: case study of Vietnamese steel industry-leaching of heavy metals from steel-making slag.

Steel slag is an industrial by product of steel manufacturing processes and has been widely utilized within civil and construction materials for road materials and environmental remediation in countries like Japan, USA, and European Union nations. However, the current utilization of steel slag in Vietnam is very low mainly because of lack of quality control of slag treatment and chances for reuse of treated steel slag. This paper presents the up to date steel slag production status in Vietnam through the extensive survey and sampling at seven large steel factories.

Identification and Biodegradation Potential of a Novel Strain of Kosakonia oryzae Isolated from a Polyoxyethylene Tallow Amine Paddy Soil.

Polyoxyethylene tallow amine (POEA) is a nonionic surfactant added to insecticide and herbicide formulations. Experimental data have been shown the toxic effects of POEA on aquatic organisms and remain to be a serious concern. In this study, total of thirty-two potential bacteria that were isolated from herbicide-contaminated soil samples showed the ability to use POEA as the sole carbon and energy source.

The Use of Laminates of Commercially Available Fabrics for Anti-Stab Body-Armor.

Modern personal protective armor has been generally based on the Kevlar fabrics, with the main goal to offer defense against bullets. In addition to the high cost and poor processability, Kevlar has the disadvantage of limited stab-proofing capability. On the other hand, a large number of crimes involving deadly injures represent knife attacks.

Antagonist Concepts of Polypyrrole Actuators: Bending Hybrid Actuator and Mirrored Trilayer Linear Actuator.

Following the natural muscle antagonist actuation principle, different adaptations for "artificial muscles" are introduced in this work. Polypyrrole (PPy) films of different polymerization techniques (potentiostatic and galvanostatic) were analyzed and their established responses were combined in several ways, resulting in beneficial actuation modes. A consecutive "one-pot" electrosynthesis of two layers with the different deposition regimes resulted in an all-PPy bending hybrid actuator.

Insulinoma-associated protein 1 (INSM1): a potential biomarker and therapeutic target for neuroendocrine tumors.

Background: Insulinoma-associated protein 1 (INSM1), a transcriptional regulator with a zinc-finger DNA-binding domain, has been validated as a cytoplasmic marker for neuroendocrine differentiation of tumor cells. Next to its abundant expression in the fetal pancreas, it is expressed in brain tumors, pheochromocytomas, medullary thyroid carcinomas, insulinomas and pituitary and small-cell lung carcinomas. INSM1 is not expressed in normal adult tissues and/or most non-neuroendocrine tumors.

Printed PEDOT:PSS Trilayer: Mechanism Evaluation and Application in Energy Storage.

Combining ink-jet printing and one of the most stable electroactive materials, PEDOT:PSS (poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)), is envisaged to pave the way for the mass production of soft electroactive materials. Despite its being a well-known electroactive material, widespread application of PEDOT:PSS also requires good understanding of its response. However, agreement on the interpretation of the material's activities, notably regarding actuation, is not unanimous.

Alfa glucosidase inhibitory, anti inflammatory activities and a new furanocoumarin derivative of .

L. is used for treatment of diabetes mellitus, anti-inflammation, etc. However, its hypoglycaemic and anti inflammatory activities has not been investigated so far.

Draft genome sequence data of VN1, a strain capable of producing natural astaxanthin.

strain VN1 is of special interest because of its capability for high astaxanthin production. Here, we report the draft genome sequence of VN1, which comprises 20.01 Mb in 424 contigs with an overall G + C content of 61.

A new triterpenoid and other compounds from lichens Makhija & Patw.

Ten compounds () were purified from the extract of lichens , and among these one new triterpenoid, cryptothecin A () was characterized through mass spectrometric and 2D NMR spectroscopic analyses. Some of the isolated compounds were assessed for their antimicrobial (, , and ) and cytotoxic activity (, , and ), but only weak inhibitory effects were observed.

Triterpenoids and steroids from the fruiting bodies of and their cytotoxicity.

One new triterpenoid, hexagonin F () was characterized from the fruiting bodies of with the assistance of spectroscopic and spectrometric analytical methods. In addition, two triterpenoids and two steroids were also identified by comparison of their physical and spectroscopic data with those reported. The purified compounds were examined for their cytotoxicity against five tumor cell lines, however, only weak cytotoxicity was demonstrated.