Publications by authors named "Nguyen Ngoc Thanh Luan"
Article Synopsis
- Researchers successfully synthesized nine isoflavone natural products using 2,4,6-trihydroxyacetophenone as the starting material.
- The key reaction employed in constructing the isoflavone structure was the Suzuki-Miyaura coupling.
- Among the compounds studied, millexatin F showed the best potential as a therapeutic agent for transthyretin (TTR) amyloidosis, making it a promising candidate for further development.
Transthyretin amyloidosis is a fatal disorder caused by transthyretin amyloid aggregation. Stabilizing the native structure of transthyretin is an effective approach to inhibit amyloid aggregation. To develop kinetic stabilizers of transthyretin, it is crucial to explore compounds that selectively bind to transthyretin in plasma.
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