Preservation of satellite cell number and regenerative potential with age reveals locomotory muscle bias.

Background: Although muscle regenerative capacity declines with age, the extent to which this is due to satellite cell-intrinsic changes vs. environmental changes has been controversial. The majority of aging studies have investigated hindlimb locomotory muscles, principally the tibialis anterior, in caged sedentary mice, where those muscles are abnormally under-exercised.

GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner.

Glucagon-like peptide 1 (GLP-1) is known to suppress glucagon secretion, but the mechanism by which GLP-1 exerts this effect is unclear. In this study, we demonstrated GLP-1 receptor (GLP-1R) expression in α-cells using both antibody-dependent and antibody-independent strategies. A novel α-cell-specific GLP-1R knockout (αGLP-1R) mouse model was created and used to investigate its effects on glucagon secretion and glucose metabolism.

Anticoagulation Management Outcomes in Veterans: Office vs Telephone Visits.

Patients on anticoagulation therapy who transitioned to telephone visits from office visits showed no change in therapeutic outcomes.

Mode of anesthesia and clinical outcomes of patients undergoing Cesarean delivery for invasive placentation: a retrospective cohort study of 50 consecutive cases.

Purpose: Invasive placentation is one of the most important causes of postpartum hemorrhage and Cesarean hysterectomies (CHyst). The optimal mode of anesthesia in the management of these patients remains uncertain. The purpose of this study was to review the impact of mode of anesthesia on maternal and neonatal outcomes in women with invasive placentation undergoing Cesarean delivery (CD).

Carbetocin at Cesarean delivery for labour arrest: a sequential allocation trial to determine the effective dose.

Purpose: The aim of this study was to estimate the effective dose 90% (ED90) of carbetocin to provide adequate uterine tone at Cesarean delivery (CD) for labour arrest.

Methods: We conducted a double-blind dose-finding study of carbetocin using a biased-coin up-and-down design in women undergoing CD for labour arrest under epidural anesthesia. Forty healthy term pregnant women who had received at least three hours of oxytocin infusion during labour were recruited for the study.

Controversy between anesthesiologists and obstetricians on the labour ward: the Delphi method is used as a consensus-building technique.

Purpose: Obstetricians and anesthesiologists may interpret medical evidence differently, which could potentially generate conflict and compromise patient care. We sought to identify the most important controversial topics involving obstetricians and anesthesiologists on the labour ward that had the potential to affect patient outcome.

Methods: We conducted a consensus-building study based on the Delphi technique.

Population-based cancer survival in sites in Viet Nam.

Background: Very few population-based cancer survival studies have been performed in Viet Nam. The aim of the present study was to estimate observed and relative cancer survival rates in populations of Phu Tho, Hanoi and Hue city.

Methods: A retrospective-cohort study was performed for all 12 districts of Phu Tho province (semi-highland area in the north), eight districts of Hanoi city (Capital) and four districts of Hue city in central area).