Numerical study on a facing electrode configuration dielectrophoresis microfluidic system for efficient biological cell separation.

Circulating tumor cell separation has been the focus of numerous studies owing to its importance in the diagnosis, prognosis, and therapy of cancer. This study reports a highly efficient microfluidic device that integrates a specialized dielectrophoresis configuration, namely the facing-electrode configuration dielectrophoresis (FEC-DEP) structure, to isolate circulating tumor cells (CTCs) from various blood components, including red blood cells, white blood cells, and platelets. The FEC-DEP design features a bottom-slanted electrode array positioned parallel to a basic rectangular top electrode.

Mineralized Biopolymers-Based Scaffold Encapsulating with Dual Drugs for Alveolar Ridge Preservation.

Mineralization of scaffolds is essential for alveolar ridge preservation and bone tissue engineering, enhancing the mechanical strength and bioactivity of scaffolds, and promoting better integration with natural bone tissue. While the in situ mineralization method using concentrated SBF solutions is promising, there is limited comprehensive research on its effects. In this study, it is demonstrate that soaking gelatin/alginate scaffolds (GAS) in fivefold concentrated SBF significantly reduces the mineralization time to 3-7 days but also leads to considerable degradation and loss of the scaffold's original microstructure.

Polypyrrole/iron-glycol chitosan nanozymes mediate M1 macrophages to enhance the X-ray-triggered photodynamic therapy for bladder cancer by promoting antitumor immunity.

X-ray Photodynamic Therapy (XPDT) is an emerging, deeply penetrating, and non-invasive tumor treatment that stimulates robust antitumor immune responses. However, its efficacy is often limited by low therapeutic delivery and immunosuppressant within the tumor microenvironment. This challenge can potentially be addressed by utilizing X-ray responsive iron-glycol chitosan-polypyrrole nanozymes (GCS-I-PPy NZs), which activate M1 macrophages.

Phototactic/Photosynthetic/Magnetic-Powered Chlamydomonas Reinhardtii-Metal-Organic Frameworks Micro/Nanomotors for Intelligent Thrombolytic Management and Ischemia Alleviation.

Thrombosis presents a critical health threat globally, with high mortality and incidence rates. Clinical treatment faces challenges such as low thrombolytic agent bioavailability, thrombosis recurrence, ischemic hypoxia damage, and neural degeneration. This study developed biocompatible Chlamydomonas Reinhardtii micromotors (CHL) with photo/magnetic capabilities to address these needs.

Sequential management of burn wound healing stages through biointelligence-inspired platelet extracellular vesicle-encapsulated photodynamic diferuloylmethane.

The process of wound healing is a complex, multi-phase phenomenon crucial for optimal tissue regeneration. Traditional drug delivery systems often target specific phases of wound repair, neglecting the dynamic interplay among the stages. This limitation highlights the need for comprehensive delivery systems that cater to the holistic needs of wound healing, enhancing tissue regeneration efficiency.

Bio-intelligent plasma-engineered diferuloylmethane/fucoidan/neutrophil lysate/iron oxide nanoclusters for phototherapeutic and magnetotherapeutic with in situ magnetic gelation mitigating inflammatory diseases.

Creating a versatile and remotely self-assembling biocomposite for delivering therapeutics to alleviate inflammatory diseases poses significant challenges. This study introduces a novel biocomposite, created through cold-atmosphere plasma treatment, that combines fucoidan (Fu) and neutrophil lysate (Nu) to mediate the self-assembly of diferuloylmethane (DIF) and iron oxide (IO) nanoclusters, termed DIF-Nu/Fu-IO NC. This biocomposite forms a phototherapeutic and magnetically-driven in situ gel with open-porous architecture loaded with DIF, offering non-invasive theranostic capabilities for treating inflammatory diseases.

Advancing teeth whitening efficacy via dual-phototherapeutic strategy incorporating molybdenum disulfide embedded in carrageenan hydrogel for dental healthcare.

Teeth discoloration poses a widespread challenge in dental health across various regions. Conventional teeth whitening methods often result in enamel deterioration and soft tissue harm due to the utilization of incompatible whitening agents and continuous intense light exposure. Here, we propose an effective phototherapy technique for teeth whitening, employing pathways of energy transition through intersystem crossing.

A review on revolutionizing ophthalmic therapy: Unveiling the potential of chitosan, hyaluronic acid, cellulose, cyclodextrin, and poloxamer in eye disease treatments.

Ocular disorders, encompassing both common ailments like dry eye syndrome and more severe situations for instance age-related macular degeneration, present significant challenges to effective treatment due to the intricate architecture and physiological barriers of the eye. Polysaccharides are emerging as potential solutions for drug delivery to the eyes due to their compatibility with living organisms, natural biodegradability, and adhesive properties. In this review, we explore not only the recent advancements in polysaccharide-based technologies and their transformative potential in treating ocular illnesses, offering renewed optimism for both patients and professionals but also anatomy of the eye and the significant obstacles hindering drug transportation, followed by an investigation into various drug administration methods and their ability to overcome ocular-specific challenges.

Relationship of Recurrence Rate with some Characteristics in Patients with Thyroid Carcinoma.

Background: Determining the clinical and subclinical characteristics related to the recurrence status in patients with a thyroid carcinoma has great significance for prognosis, prediction of recurrence and monitoring of treatment outcomes. This study aimed to determine the association between recurrence rate and some characteristics in patients with thyroid carcinoma.

Patients And Methods: The study was conducted by descriptive method with longitudinal follow-up on 102 thyroid carcinoma patients at 103 Military Hospital, Hanoi, Vietnam, from July 2013 to December 2016.

Emerging horizons and prospects of polysaccharide-constructed gels in the realm of wound healing.

Polysaccharides, with the abundant availability, biodegradability, and inherent safety, offer a vast array of promising applications. Leveraging the remarkable attributes of polysaccharides, biomimetic and multifunctional hydrogels have emerged as a compelling avenue for efficacious wound dressing. The gels emulate the innate extracellular biomatrix as well as foster cellular proliferation.

Dual anticancer and antibacterial activity of fluorescent naphthoimidazolium salts.

Cancer has emerged as a significant global health challenge, ranking as the second leading cause of death worldwide. Moreover, cancer patients frequently experience compromised immune systems, rendering them susceptible to bacterial infections. Combining anticancer and antibacterial properties in a single drug could lead to improved overall treatment outcomes and patient well-being.

Quantitative Evaluation of Caries and Calculus with Ultrahigh-Resolution Optical Coherence Tomography.

Dental caries on the crown's surface is caused by the interaction of bacteria and carbohydrates, which then gradually alter the tooth's structure. In addition, calculus is the root of periodontal disease. Optical coherence tomography (OCT) has been considered to be a promising tool for identifying dental caries; however, diagnosing dental caries in the early stage still remains challenging.

Intussusception following diaphragmatic rupture surgery: A rare case.

Introduction And Importance: Intussusception in adults is a rare manifestation after traumatic abdominal surgery, because after abdominal surgery patients often have functional bowel paralysis rather than increased intestinal motility.

Case Presentation: 39-year-old male patient with acute intussusception appeared after surgery for diaphragmatic rupture and is undergoing postoperative treatment on day 7. The patient has clinical manifestations of small bowel obstruction.

Bandgap tuning of TiO by Cu nanoparticles applied in photocatalytic antifouling-coated PES membranes through PAA-plasma grafted adhesive layer.

This study developed an antifouling coating for polyethersulfone (PES) membranes by tuning the bandgap of TiO with Cu nanoparticles (NPs) via a polyacrylic acid (PAA)-plasma-grafted intermediate layer. Cu NPs were synthesized at different molar ratios and precipitated onto TiO using the sol-gel method. The resulting Cu@TiO photocatalysts were characterized using various techniques, showing reduced bandgap, particle size range of 100-200 nm, and generation of reactive free radicals under light irradiation.

Determination of conditioning factors for mapping nickel contamination susceptibility in groundwater in Kanchanaburi Province, Thailand, using random forest and maximum entropy.

Groundwater pollution from nickel (Ni) has been a severe concern in Kanchanaburi Province, Thailand. Recent assessments revealed that the Ni concentration in groundwater, particularly in urban areas, often exceeded the permissible limit. The challenge for groundwater agencies is therefore to delineate regions with high susceptibility to Ni contamination.

Chitosan Modified by Kombucha-Derived Bacterial Cellulose: Rheological Behavior and Properties of Convened Biopolymer Films.

This work investigates the rheological behavior and characteristics of solutions and convened biopolymer films from Chitosan (Chi) modified by kombucha-derived bacterial cellulose (KBC). The Arrhenius equation and the Ostwald de Waele model (power-law) revealed that the Chi/KBC solutions exhibited non-Newtonian behavior. Both temperature and KBC concentration strongly affected their solution viscosity.

Antifouling CuO@TiO coating on plasma-grafted PAA/PES membrane based on photocatalysis and hydrogen peroxide activation.

Because of the small size effect leading to the high bandgap of TiO P25, the photocatalytic membrane using this photocatalyst has low antifouling efficiency. This study prepared CuO@TiO composite photocatalyst with a lower bandgap than TiO P25 and used it as antifouling coatings on the PES membrane with PAA intermediate adhesive layer. PAA was grafted onto the surface of the PES membranes through free radicals generated by the cold plasma treatment of the PES membrane.

Gellan gum/bacterial cellulose hydrogel crosslinked with citric acid as an eco-friendly green adsorbent for safranin and crystal violet dye removal.

In this study, ex-situ crosslinked gellan gum (GG)/bacterial cellulose (BC) hydrogels have been investigated as good absorbents for the removal of safranin and crystal violet dye pollutants. The preparation involves a cost-effective and easy-to-perform crosslinking procedure, using citric acid (CA) as a green crosslinker. The physicochemical and mechanical properties of the crosslinked hydrogels were examined by FTIR, TGA, SEM, XRD, and unconfined compression analyses.

Antifouling catalytic mixed-matrix membranes based on polyethersulfone and composition-optimized Zn-Cu-Fe-O CWAO catalyst under dark ambient conditions.

Besides photocatalysts, novel catalytic wet-air oxidation (CWAO) catalysts capable of operating under mild conditions are a potential candidate to fabricate antifouling filtration membranes. This study optimized the CWAO catalyst consisting of three metal oxide components (ZnO, CuO, and FeO) and used it to fabricate composite membranes with PES (polyethersulfone). The catalyst was characterized by methods such as FTIR, BET, XRD, UV-Vis DRS, XPS, ESR.

Seroprevalence of SARS-CoV-2 Neutralizing Antibodies among Blood Donors in Ho Chi Minh City, Vietnam, August-November 2020.

Relatively little is known about the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG antibodies and COVID-19-related behaviors in the general population in Vietnam, where the first case of COVID-19 was detected on January 22, 2020. We surveyed a group of 885 blood donors at community blood donation sessions in Ho Chi Minh City from August 27 to November 7, 2020. Blood was collected to test for SARS-CoV-2 IgG antibodies using the plaque reduction neutralization test.

Pesticide production wastewater treatment by Electro-Fenton using Taguchi experimental design.

In this study, the electro-Fenton (EF) method was applied to remove total organic carbon (TOC) from the pesticide production wastewater containing tricyclazole (TC). Statistical Taguchi method was used to optimize the treatment performance. Analysis of variance (ANOVA) indicated that the polynomial regression model fitted experimental data with R of 0.

Enzymatically triggered graphene oxide released from multifunctional carriers boosts anti-pathogenic properties for promising wound-healing applications.

Spurred by recent progress in biomaterials and therapeutics, stimulus-responsive strategies that deliver an active substance in temporal-, spatial-, and dose-controlled fashions have become achievable. Implementation of such strategies necessitates the use of bio-safe materials that are sensitive to a specific pathological incitement or that, in response to a precise stimulus, undergo hydrolytic cleavage or a change in biomolecular conformation. An innovative design of polymeric stimulus-responsive systems should controllably release a drug or degrade the drug carrier in response to specific lesion enzymes.