Publications by authors named "Ngoc-Trinh Tran"
Objectives: The recent expansion of eligibility for cochlear implantation (CI) by the U.S. Food and Drug Administration (FDA) to include infants as young as 9 months has reignited debates concerning the clinically appropriate cut-off age for pediatric CI.
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- Osteoarthritis (OA) results from an imbalance in cartilage tissue synthesis and degradation, and a new therapeutic agent that can help with both is needed, as existing treatments show limited long-term success in cartilage repair.
- This study focuses on the human fetal cartilage progenitor cells-secretome (ShFCPC), analyzing its effects in comparison to human bone marrow-derived mesenchymal stem cells-secretome (ShBMSC) and hyaluronan (HA) through secretome analysis and evaluations in both lab and animal models of OA.
- Key findings reveal that ShFCPC is rich in extracellular matrix molecules that aid in maintaining cellular activities during OA, and it effectively protects against cell death and promotes cartilage repair by reducing inflammation and improving the healing
Stem cells are known to have excellent regenerative ability, which is primarily facilitated by indirect paracrine factors, rather than via direct cell replacement. The regenerative process is mediated by the release of extracellular matrix molecules, cytokines, and growth factors, which are also present in the media during cultivation. Herein, we aimed to demonstrate the functionality of key factors and mechanisms in skin regeneration through the analysis of conditioned media derived from fetal stem cells.
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