Publications by authors named "Ngoc-Hanh Hau Desbat"
Article Synopsis
- - Purpose: The study aims to evaluate the prevalence, characteristics, and management of pain in a radiotherapy department at a French hospital, while also suggesting ways to improve pain screening and treatment.
- - Methods: A cross-sectional study involving a standardized questionnaire was conducted over two days with 91 patients undergoing radiotherapy treatment, focusing on pain experiences and management.
- - Results: 63.7% of patients reported experiencing pain in daily life, especially those with brain tumors, bone metastasis, and head/neck cancers. While 70.7% received pain relief, awareness of the hospital's pain specialist unit was low, with only 5.5% offered a consultation, highlighting the need for better integration of pain management
Article Synopsis
- The study examines the link between post-radiation therapy overreactions (OR) in patients and their clinical radiosensitivity, highlighting the lack of consensus on effective prediction methods since 2003.
- Researchers collected skin biopsy samples from patients with varying degrees of OR, focusing on skin fibroblasts from different sensitivity groups and analyzing their DNA damage response after radiation.
- Findings suggest that OR patients experience a delay in the ATM protein's activity rather than a complete repair defect, leading to a proposed classification of human radiosensitivity into three groups based on their reaction severity.
Since the 1990, chemoradiation has become the standard treatment for locally advanced anal cancer. Recent progress in molecular biology and the growing number of elderly patients invite the clinicians to personalize the multimodal therapy strategy. However, data about anal cancer and elderly patients or targeted therapy are extremely sparse.
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