Plasmonic Porous ZIF-8/Au NPs Platforms: A Complex Matrix Enhances SERS Substrate for Micromolar-Trace Detection of Several Analytes.

Surface-enhanced Raman scattering (SERS) is an advantageous method for organic chemical and biological sensing. Benzoic acid, benzisothiazolinone, and thiram are common model compounds used to study the interaction of toxic substances with metal surfaces using SERS spectroscopy. Metal-organic frameworks, with their high porosity and large surface area, have recently received a lot of attention in sensing applications.

Successful management of cesarean scar pregnancy progressive to placenta accreta spectrum: An uncommon condition in Vietnam and mini-review of the literature.

Introduction And Importance: Cesarean scar pregnancy (CSP) is an uncommon ectopic pregnancy that could be progressive to the placenta accreta spectrum (PAS). It is defined as abnormal trophoblast invasion of part or all of the placenta into the myometrium of the uterine wall, with varying degrees of severity. These abnormal pathologies of placental implantation could lead to life-threatening complications for pregnant women.

Polyethylene glycol hexadecyl ether modified heparin for paclitaxel nano-delivery system.

A paclitaxel (PTX) nano-delivery system using modified heparin and polyethylene glycol hexadecyl ether (Brij 58) was developed in this study. Brij 58 was conjugated to the heparin backbone via the cystamine bridge and donated as Hep-Brij 58 to facilitate the self-assembly into stable nanoparticles in aqueous. The self-assembled formation of Hep-Brij nanoparticles was demonstrated through DLS and TEM, whereas the iodine method identified the critical concentration for the self-assembled process.

Analytic and Monte Carlo calculations of dose-mean lineal energy for 1 MeV-1 GeV protons with application to radiation protection quality factor.

Radiation quality for determining biological effects is commonly linked to the microdosimetric quantity lineal energy ( ) and to the dose-mean lineal energy ( ). Calculations of are typically performed by specialised Monte Carlo track-structure (MCTS) codes, which can be time-intensive. Thus, microdosimetry-based analytic models are potentially useful for practical calculations.

Metallothionein-3-mediated intracellular zinc mediates antioxidant and anti-inflammatory responses in the complete Freund's adjuvant-induced inflammatory pain mouse model.

Chronic inflammatory pain is often caused by peripheral tissue damage and persistent inflammation. This disease substantially affects patients' physical and social well-being. We investigated the role of metallothionein-3 (MT3) in modulating complete Freund's adjuvant (CFA)-induced intracellular Zn activity in an MT3 knockout mouse model of inflammatory pain in the hind paw.

Isolation and Evaluation of Potential Use of Prebiotics-Utilizing Butyrate-Producing Bacteria in .

Butyrate-producing bacteria (BPB) benefit the health of aquatic animals. This current study aimed to isolate BPB from the intestines of and assess their probiotic potential. The results showed that nine isolates were obtained in vitro from the gut of , including six , two , and one .

AAVone: A Cost-Effective, Single-Plasmid Solution for Efficient AAV Production with Reduced DNA Impurities.

Currently, the most common approach for manufacturing GMP-grade adeno-associated virus (AAV) vectors involves transiently transfecting mammalian cells with three plasmids that carry the essential components for production. The requirement for all three plasmids to be transfected into a single cell and the necessity for high quantities of input plasmid DNA, limits AAV production efficiency, introduces variability between production batches, and increases time and labor costs. Here, we developed an all-in-one, single-plasmid AAV production system, called AAVone.

Fabricating ZnO@C composites based on shell-derived cellulose for high performance lithium-ion battery anodes.

In this study, shell-derived cellulose was successfully produced, and the hydrothermal method was employed to generate ZnO@C (ZOC) composites, which were then subjected to calcination in N gas at a temperature of 600 °C for varying durations. X-ray diffraction and thermogravimetric analyses demonstrated that the annealing duration had a substantial impact on the quantities of C and ZnO in the ZOC composites. The scanning electron microscope images indicated the presence of ZnO nanoparticles on the surface of the C phase and revealed a similar morphology among the ZOC composites.

Synergistic effects of butyrate-producing bacteria (Clostridium senegalense I5 or Paraclostridium benzoelyticum G5) and Gracilaria lemaneiformis-originated polysaccharides on the growth and immunity of rabbitfish.

This study evaluated the synergistic effects of dietary butyrate-producing bacteria (Clostridium senegalense I5 (I5) and Paraclostridium benzoelyticum G5 (G5) and Gracilaria lemaneiformis-derived polysaccharide (GLP) in rabbitfish (Siganus canaliculatus). Both bacterial strains demonstrated high susceptibility to most antibiotics, salt tolerance up to 6.5 %, pH tolerance ranging from 2 to 10, and strong auto-aggregation abilities.

Effects of dietary probiotic ( I9, G15, or X13) on growth, digestive enzyme activities, immunity, and intestinal microbiota of Pacific white shrimp ().

Pacific white shrimp () is one of the most productive and economically important species globally. However, the development and continuous expansion of the farming scale led to an increase in the risk of disease occurrence in shrimp farming. The application of probiotics as an effective method for controlling diseases in aquaculture has been widely considered.

Factors influencing Generation Z's intention to purchase sustainable clothing products in Vietnam.

The increasing awareness of environmental challenges has significantly influenced consumer behavior, with sustainable products, particularly sustainable clothing, becoming a top priority for Generation Z consumers. This study aims to investigate the factors influencing Generation Z's purchase intentions toward sustainable clothing in Vietnam, guided by the Stimulus-Organism-Response (SOR) model and Theory of Planned Behavior (TPB) frameworks. Specifically, it examines the effects of green perceived value, green perceived quality, perceived price, social influence, product design, environmental concern, and environmental knowledge on purchase intentions.

Frailty as an independent predictor for midterm adverse outcomes in the elderly undergoing primary percutaneous coronary intervention: A longitudinal cohort study.

Background: Frailty is associated with poor health outcomes in elderly population. However, its effect on midterm outcomes in elderly patients undergoing primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) remains unknown.

Aims: This study aimed to evaluate the association between frailty, as classified by the Clinical Frailty Scale (CFS), and midterm adverse outcomes in elderly STEMI patients after primary PCI.

Exosome-mediated viral nucleic acid presentation in a crustacean expounds innate immunity from a novel perspective.

Unlabelled: As an enduring hot topic in the field of innate immunity, apoptosis is widely considered an effective approach to eliminate pathogenic microbes and plays a crucial role during host-pathogen interactions. Recently, researchers have found that the virus-containing host cells could transmit apoptotic signals to the surrounding uninfected cells during infection, but the mechanism remains unclear. Here, we found that exosomes secreted by WSSV-infected mud crab hemocytes contain viral nucleic acid wsv277, which could be transported to the recipient cells and further expressed viral protein with phosphokinase activity.

Durvalumab Versus Chemotherapy as First-line Treatment for Metastatic NSCLC With Tumor PD-L1 Expression of 25% or Higher: Results From the Randomized Phase 3 PEARL Study.

Introduction: PEARL (NCT03003962) is an open-label, phase 3 study comparing first-line durvalumab monotherapy with chemotherapy in patients with metastatic NSCLC (mNSCLC [EGFR/ALK wild type]) with programmed cell death ligand 1 (PD-L1) tumor cell (TC) membrane expression status of 25% or higher. We report the final analysis of PEARL.

Methods: Adults (N = 669) with previously untreated stage IV mNSCLC were randomized (1:1) to durvalumab 20 mg/kg every four weeks or chemotherapy every three weeks for four to six cycles.

Trends in head and neck cancer incidence in Ho Chi Minh City, Vietnam between 1996 and 2015.

Introduction: This study provides an analysis of head and neck cancer (HNC) cases over a 20-year period in Ho Chi Minh City, Vietnam. It aims to shed light on HNC's characteristics and trends in this highly populated urban region.

Methods: The analysis encompasses 8974 HNC cases, emphasising incidence rates, gender distribution, and the prevalence of different subtypes, including oral cavity, nasopharyngeal, oropharyngeal, and laryngeal/pharyngeal cancers.

The gaming disorder test and gaming disorder scale for adolescents: translation and validation among Vietnamese young adults.

Background: Previous studies have shown that the Gaming Disorder Test (GDT) and Gaming Disorder Scale for Adolescents (GADIS-A) have promising validity and reliability when assessing symptoms of gaming disorder among young adults. However, validity and reliability properties of the two scales have not been established among a Vietnamese population.

Objective: The present study translated the GDT and GADIS-A into Vietnamese and examined their factor structures, measurement invariance, convergent validity, concurrent validity, and divergent validity among university students.

Low shear-induced fibrillar fibronectin: comparative analyses of morphologies and cellular effects on bovine aortic endothelial cell adhesion and proliferation.

Wall shear stress (WSS) is a critical factor in vascular biology, and both high and low WSS are implicated in atherosclerosis. Fibronectin (FN) is a key extracellular matrix protein that plays an important role in cell activities. Under high shear stress, plasma FN undergoes fibrillogenesis; however, its behavior under low shear stress remains unclear.

NovoBoard: A Comprehensive Framework for Evaluating the False Discovery Rate and Accuracy of De Novo Peptide Sequencing.

De novo peptide sequencing is one of the most fundamental research areas in mass spectrometry-based proteomics. Many methods have often been evaluated using a couple of simple metrics that do not fully reflect their overall performance. Moreover, there has not been an established method to estimate the false discovery rate (FDR) of de novo peptide-spectrum matches.

Comparing smell identification ability among different motor subtypes of Parkinson's disease using the Vietnamese Smell Identification Test and the Brief Smell Identification Test.

Introduction: Olfactory dysfunction is one of the most common non-motor symptoms of Parkinson's disease (PD). The association between smell identification ability and motor subtypes of PD is not uniform in previous studies. This study aimed to compare the odor identification ability among different motor subtypes of PD in Vietnamese participants.

Crystalline Ru-Decorated MOF-Derived Amorphous CoMo-LDH Nanosheet Arrays as Bifunctional Catalysts for Overall Natural Seawater Electrolysis.

The construction of an amorphous/crystalline heterostructure of MOF-derived electrocatalysts offers an intriguing pathway to improve hydrogen production efficiency, but it has received little attention. Here, we report crystalline Ru-decorated MOF-derived amorphous CoMo-LDH nanosheet arrays as highly active and robust bifunctional electrocatalysts for natural seawater electrolysis. Benefiting from the abundant interfaces, the Ru-CoMo-LDH catalyst exhibits excellent activity toward OER under fresh and natural seawater, in particular; it requires only 257 and 406 mV overpotential at 10 and 500 mA cm in 1 M KOH + Seawater, outperforming the benchmark RuO.

Rapidly evolving genome and epigenome editing technologies.

Genome editing technologies are rapidly evolving, from the early zinc-finger nucleases, transcription activator-like effector nucleases (TALENs), and CRISPR-Cas9 (Figure 1, initial genome editing technologies), which generate double-strand breaks (DSBs), to base editing, which makes precise nucleobase conversion without inducing DSBs, and prime editing, which can carry out all types of edits without DSBs or donor DNA templates. The emergence of these revolutionary technologies offers us unprecedented opportunities for biomedical research and therapy development.

Quantitative analysis of dose dependent DNA fragmentation in dry pBR322 plasmid using long read sequencing and Monte Carlo simulations.

Exposure to ionizing radiation can induce genetic aberrations via unrepaired DNA strand breaks. To investigate quantitatively the dose-effect relationship at the molecular level, we irradiated dry pBR322 plasmid DNA with 3 MeV protons and assessed fragmentation yields at different radiation doses using long-read sequencing from Oxford Nanopore Technologies. This technology applied to a reference DNA model revealed dose-dependent fragmentation, as evidenced by read length distributions, showing no discernible radiation sensitivity in specific genetic sequences.

In vitro validation of helium ion irradiations as a function of linear energy transfer in radioresistant human malignant cells.

Purpose: Based on considerable interest to enlarge the experimental database of radioresistant cells after their irradiation with helium ions, HTB140, MCF-7 and HTB177 human malignant cells are exposed to helium ion beams having different linear energy transfer (LET).

Materials And Methods: The cells are irradiated along the widened 62 MeV/u helium ion Bragg peak, providing LET of 4.9, 9.