Publications by authors named "Ngoc Tan Tran"
Microb Cell Fact
April 2015
Article Synopsis
- Salmonella enterica serovar Enteritidis (SE) is a major cause of food-borne disease, and previous attempts to use E. coli as a vaccine vehicle for its flagellar protein (H:gm) faced challenges due to the protein being cleaved.
- Researchers created a truncated version of H:gm (H:gmd) that could be expressed successfully, along with a fusion protein with the fimbrial protein SefA to improve its display and immune response.
- The study found that both H:gmd and the fusion protein were effectively displayed on E. coli's surface and could trigger a pro-inflammatory response in intestinal cells, marking progress towards a potential vaccine against Salmonella infections.
