Publications by authors named "Ngoc Quynh H Nguyen"
Article Synopsis
- Researchers studied plasma proteomic profiles linked to subclinical mutations in blood cells, particularly focusing on clonal hematopoiesis of indeterminate potential (CHIP) and its connection to various health outcomes, including coronary artery disease (CAD).
- The study involved a large, diverse group of participants and identified a significant number of unique proteins associated with key driver genes, showing differences based on genetics, sex, and race.
- Methods like Mendelian randomization and mouse model tests helped clarify the causal effects of these proteins, revealing shared plasma proteins between CHIP and CAD that could inform future clinical insights.
The abundance of Lp(a) protein holds significant implications for the risk of cardiovascular disease (CVD), which is directly impacted by the copy number (CN) of KIV-2, a 5.5 kbp sub-region. KIV-2 is highly polymorphic in the population and accurate analysis is challenging.
View Article and Find Full Text PDFFully characterizing the genetic architecture of circulating proteins in multi-ancestry populations provides an unprecedented opportunity to gain insights into the etiology of complex diseases. We characterized and contrasted the genetic associations of plasma proteomes in 9,455 participants of European and African (19.8%) ancestry from the Atherosclerosis Risk in Communities Study.
View Article and Find Full Text PDFBackground: Older adults have markedly increased risks of heart failure (HF), specifically HF with preserved ejection fraction (HFpEF). Identifying novel biomarkers can help in understanding HF pathogenesis and improve at-risk population identification. This study aimed to identify metabolites associated with incident HF, HFpEF, and HF with reduced ejection fraction and examine risk prediction in older adults.
View Article and Find Full Text PDFArticle Synopsis
- Age-related changes in DNA methylation patterns in blood are linked to health issues like blood cancer and coronary artery disease (CAD), particularly through a condition called clonal hematopoiesis of indeterminate potential (CHIP).
- The study focused on two frequently mutated genes associated with CHIP, DNMT3A and TET2, which exhibit opposite patterns of DNA methylation despite both supporting the self-renewal of hematopoietic stem cells.
- Findings suggest that certain methylation changes connected to DNMT3A and TET2 could increase the risk for coronary artery disease, as verified by analyses in two different participant groups.
Article Synopsis
- Uromodulin (UMOD) is a key gene linked to both simple and complex kidney diseases, with its protein being abundant in urine and associated with conditions like chronic kidney disease and hypertension.
- Researchers conducted genome-wide screens using different assays to find significant genomic loci related to circulating uromodulin, identifying several key areas that influence its expression and functionality.
- Their findings also connect uromodulin to other complex traits and suggest that certain genetic variants can affect serum uromodulin levels, providing a deeper understanding of its systemic roles and glycosylation patterns.
Background: Age-related clonal hematopoiesis of indeterminate potential (CHIP), defined as clonally expanded leukemogenic sequence variations (particularly in DNMT3A, TET2, ASXL1, and JAK2) in asymptomatic individuals, is associated with cardiovascular events, including recurrent heart failure (HF).
Objectives: This study sought to evaluate whether CHIP is associated with incident HF.
Methods: CHIP status was obtained from whole exome or genome sequencing of blood DNA in participants without prevalent HF or hematological malignancy from 5 cohorts.
Protecting the rights of the lesbians, gays, bisexuals, transgender, intersex, and queers (LGBTIQ) population requires, first and foremost, a proper understanding of their sexual orientation and gender identity. This study highlights a severe misunderstanding and lack of knowledge among health professionals in Vietnam with regard to the men who have sex with men (MSM) and transgenders. This study uses (i) a survey based on the convenience sampling method among 150 health workers that covered 61 questions and (ii) 12 in-depth interviews in two metropolitan centres in Vietnam, Hanoi and Ho Chi Minh city.
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