Miliutine C methyl ester, a new drimane sesquiterpene and bioactive alkaloids from the stems of .

Previous results from the our research group have isolated numerous compounds, including novel ones, but the anticancer activity of has not been demonstrated. In this study, from the most active ethyl acetate extract of the stems of , seven compounds were isolated and determined structures, including a new drimane sesquiterpenoid compound named miliutine C methyl ester () and three bioactive alkaloids (-). These three alkaloids (-) exhibited strong anticancer activities against various cancer cell lines such as MCF-7, HepG2, HeLa, NCI H460 and normal fibroblasts.