Publications by authors named "Ngoc Mai Le"
Article Synopsis
- Cerebral amyloid angiopathy (CAA) leads to amyloid-beta deposition in blood vessels, causing neurovascular issues like ischemic strokes that affect brain functions, including breathing and cognition.
- The study investigates how Transforming Growth Factor Beta (TGF-β) signaling in the retrotrapezoid nucleus (RTN) impacts respiratory and cognitive functions in CAA mice, utilizing techniques like viral injections and behavioral tests.
- Results indicate that silencing TGF-βR2 in the RTN improves both respiratory and cognitive functions in CAA mice, suggesting that manipulating TGF-β signaling could be a potential therapeutic approach for these impairments.
Hyperglycemia Is Associated With Computed Tomography Perfusion Core Volume Underestimation in Patients With Acute Ischemic Stroke With Large-Vessel Occlusion.
Stroke Vasc Interv Neurol
July 2024
Background: CT Perfusion (CTP) predictions of infarct core play an important role in the determination of treatment eligibility in large vessel occlusion (LVO) acute ischemic stroke (AIS). Prior studies have demonstrated that blood glucose can affect cerebral blood flow (CBF). Here we examine the influence of acute and chronic hyperglycemia on CTP estimations of infarct core.
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- The study examines how adding endovascular stroke therapy (EST) capabilities in community hospitals affects acute ischemic stroke (AIS) admissions in a large hospital system over a period from 2014 to 2022.! -
- Data gathered from 10 hospitals showed that community hospitals transitioning to EST-performing hospitals (EPHs) experienced a 1.9% monthly increase in AIS admissions, particularly for non-large vessel occlusion strokes, while an established EPH saw a decline in admissions and treatment rates.! -
- The findings suggest that enhancing EST availability in community settings can lead to increased AIS admissions, highlighting a shift in patient care dynamics when hospitals gain EST capabilities.!
Article Synopsis
- Cerebral amyloid angiopathy (CAA) is linked to amyloid-beta deposits in blood vessels, leading to complications like ischemic strokes, metabolic issues, and respiratory dysfunctions, with a focus on the retrotrapezoid nucleus (RTN) for breathing regulation.
- The study involved CAA model mice and controls to investigate the effects of Transforming Growth Factor Beta (TGF-β) signaling in the RTN, looking at both respiratory and cognitive functions through various tests.
- Results showed that CAA mice had respiratory and cognitive impairments, but reducing TGF-β signaling in the RTN improved these functions, highlighting the role of TGF-β in contributing to dysfunction in these conditions.
The identification of ruthenium(II) polypyridyl complexes as photosensitizers in photodynamic therapy (PDT) for the treatment of cancer is progressing rapidly. Due to their favorable photophysical and photochemical properties, Ru(II)-based photosensitizers have absorption in the visible spectrum, can be irradiated via one- and two-photon excitation within the PDT window, and yield potent oxygen-dependent and/or oxygen-independent photobiological activities. Herein, we present a current overview of the mechanisms of action and subcellular localization of Ru(II)-based photosensitizers in the treatment of cancer.
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