A Model for Gastric Cancer Risk Prediction Based on Polymorphisms and Health-risk Behaviors in a Vietnamese Population.

Background/aim: Although the expression of mucin 1(MUC1) and prostate stem cell antigen (PSCA) genes is correlated with gastric cancer development and progression, the utility of these two genes as biomarkers of gastric cancer prognosis still needs to be confirmed in clinical practice. This study aimed to develop a model predictive of gastric cancer that integrates several significant single nucleotide polymorphisms (SNPs) of MUC1 and PSCA genes, and some health-risk behavior factors in a Vietnamese population.

Patients And Methods: A total of 302 patients with primary gastric carcinoma and 304 healthy persons were included in a case-control study.