Constituents, Nutrient Content, and In Vitro Antioxidant and Anti-Inflammatory Activity of Tricholomopsis aurea (Agaricomycetes) from Cameroon.

Tricholomopsis aurea is used as food in different parts of the world, but has not been investigated for its nutrients, metabolites, and biological potentials like other edible mushrooms. This work aimed to quantify the metabolic and nutrient content of T. aurea and evaluate the antioxidant and anti-inflammatory activities of the extract and isolated compounds.

Cytotoxicity of epunctanone and four other phytochemicals isolated from the medicinal plants Garcinia epunctata and Ptycholobium contortum towards multi-factorial drug resistant cancer cells.

Introduction: Resistance of cancer cells is a serious impediment to chemotherapy and several phytochemicals are active against multi-drug resistant (MDR) phenotypes. The cytotoxicity of five naturally occurring compounds: betulin (1), mundulea lactone (2), seputhecarpan A (3), seputheisoflavone (4) and epunctanone (5) was evaluated on a panel of 9 cancer cell lines including various sensitive and drug-resistant cell lines. The modes of action of compound 5 were further investigated.

Cytotoxicity of seputhecarpan D, thonningiol and 12 other phytochemicals from African flora towards human carcinoma cells.

Background: Despite the remarkable progress in cancer therapy in recent years, this disease still remains a serious public health concern. The use of natural products has been and continues to be one of the most effective ways to fight malignancies. The cytotoxicity of 14 compounds from African medicinal plants was evaluated in four human carcinoma cell lines and normal fibroblasts.

Two new pterocarpans and a new pyrone derivative with cytotoxic activities from (N.E.Br.) Brummitt (Leguminosae): revised NMR assignment of mundulea lactone.

Background: is a genus related to which comprises only three species. Compared to , which has been phytochemically and pharmacologically studied, species have only few or no reports on their chemical constituents. Moreover, no studies on the cytotoxic activities of its secondary metabolites have been previously documented.