Publications by authors named "Nghia Trung Tran"
Article Synopsis
- The study investigates the use of human pretreated umbilical cord arteries (hUCAs) as viable small-diameter vascular grafts, bypassing the need for immunosuppression.
- Findings show that hUCAs do not provoke significant immune responses, as indicated by mixed lymphocyte reaction assays and in vivo tests, where they remained stable in size and showed good integration after 30 days.
- Post-transplantation assessments in rats demonstrated positive blood flow, normal motor function, and no significant adverse effects, suggesting that hUCAs could be a promising option for vascular grafting.
Article Synopsis
- The study investigated the biocompatibility of squid ink melanin nanoparticles (NPs) on various human stromal cells and zebrafish embryos, finding they are generally non-toxic and compatible.
- The NPs did not induce cell aging or affect cell movement in human fibroblasts and stem cells, but they hindered tube formation in endothelial cells at certain concentrations.
- In zebrafish embryos, melanin NPs were shown to be safe, indicating potential for use in biomedical applications, particularly in contexts involving radiation exposure.
Background: Although umbilical cord blood (UCB) is identified as a source of mesenchymal stem cells (MSCs) with various advantages, the success in cell isolation is volatile. Therefore, it is necessary to optimize methods of cord blood-derived MSC (UCB-MSC) isolation and culture. In this study, we evaluated the efficiency of UCB-MSC isolation and expansion using different commercially available serum- and xeno-free media and investigated the capacity of autologous serum and plasma as a supplement to support cell proliferation.
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