Publications by authors named "Ngan Kim Thi Ly"
Article Synopsis
- Valproic acid and phenytoin, common antiepileptic drugs, have narrow therapeutic indices and can cause cardiovascular and respiratory toxicity, making therapeutic drug monitoring (TDM) crucial for patient safety and treatment effectiveness.
- A sensitive ultra-performance liquid chromatographic tandem mass spectrometer (UPLC-MS/MS) method was developed to simultaneously measure VAL and PHE in human plasma, using specific ionization techniques for accurate quantification.
- The method demonstrated high recovery rates and met all US-FDA bioanalytical validation criteria, successfully evaluating the drug levels in plasma from epileptic patients.
