Publications by authors named "Ngan Chau Tran"
Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization.
Van Thien Chi Nguyen Trong Hieu Nguyen Nhu Nhat Tan Doan Thi Mong Quynh Pham Giang Thi Huong Nguyen Thuy Thi Thu Tran Trung Hieu Tran Anh Minh Tran Quang Dat Tran Thuy Trang Tran Ngan Chau Tran Thanh Huong Thi Tran Duc Huy Tran Thi Minh Thu Tran Thi Trang Tran Vu Uyen Tran Le Son Tran
Elife
October 2023
Article Synopsis
- The study introduces a new assay called SPOT-MAS that combines multiple analysis techniques to detect different types of cancer using circulating tumor DNA (ctDNA).
- SPOT-MAS was tested on a large group of 738 patients with various cancers and 1550 healthy controls, successfully identifying cancers with a sensitivity of 72.4% and high specificity.
- The assay performs well for early-stage cancers and shows promise for being more cost-effective compared to other ctDNA tests due to its lower sequencing depth requirements.
Article Synopsis
- Breast cancer is a leading cause of cancer-related death among women in the US, with current screening methods often hindered by high false positive rates.
- Researchers developed a new approach called SPOT-MAS, analyzing cell free DNA from 239 breast cancer patients and 278 healthy individuals.
- The study revealed that combining different DNA signatures significantly improved detection accuracy for early-stage breast cancer, achieving a high AUC of 0.91, with 65% sensitivity at 96% specificity.