Publications by authors named "Ngai Kien Le"
Article Synopsis
- - The study analyzed the diversity of plasmids carrying the antibiotic resistance gene bla in Enterobacteriaceae from neonates at a pediatric hospital in Vietnam, revealing rapid and silent spread of antibiotic resistance in the region.
- - Researchers used advanced techniques like optical DNA mapping and next-generation sequencing to identify at least 10 distinct plasmids among 18 bacterial isolates, indicating significant genetic variation.
- - The findings emphasize the coexistence of multiple plasmids encoding the same bla gene within individual isolates, showcasing the effectiveness of optical DNA mapping in understanding plasmid diversity and antibiotic resistance.
Clonal spread of carbapenem-resistant Klebsiella pneumoniae among patients at admission and discharge at a Vietnamese neonatal intensive care unit.
Antimicrob Resist Infect Control
November 2021
Background: The increasing prevalence of carbapenem-resistant Enterobacteriaceae (CRE) is a growing problem globally, particularly in low- to middle-income countries (LMICs). Previous studies have shown high rates of CRE colonisation among patients at hospitals in LMICs, with increased risk of hospital-acquired infections.
Methods: We isolated carbapenem-resistant Klebsiella pneumoniae (CRKP) from faecal samples collected in 2017 from patients at admission and discharge at a Vietnamese neonatal intensive care unit (NICU).
Background: Carbapenem-resistant are becoming increasingly common in hospital settings worldwide and are a source of increased morbidity, mortality and health care costs. The global epidemiology of carbapenem-resistant is characterized by different strains distributed geographically, with the strain ST258 being predominant in Europe and USA, and ST11 being most common in East Asia. ST15 is a less frequently occurring strain but has nevertheless been reported worldwide as a source of hospital outbreaks of carbapenem-resistant .
View Article and Find Full Text PDFInsertion sequence transpositions and point mutations in mgrB causing colistin resistance in a clinical strain of carbapenem-resistant Klebsiella pneumoniae from Vietnam.
Int J Antimicrob Agents
May 2018
Resistance among Klebsiella pneumoniae to the last-resort antibiotics carbapenems and colistin is increasing worldwide. In this study, whole-genome sequencing was used to determine the colistin resistance mechanisms in clinical isolates of carbapenem- and colistin-resistant K. pneumoniae from Vietnam.
View Article and Find Full Text PDFThere is scarce information regarding hospital-acquired infections (HAIs) among children in resource-constrained settings. This study aims to measure prevalence of HAIs in Vietnamese pediatric hospitals.Monthly point prevalence surveys (PPSs) in 6 pediatric intensive care units (ICUs) in 3 referral hospitals during 1 year.
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