Publications by authors named "Nga Nguyen"

Background And Aims: Acetaminophen (APAP) overdose is the leading individual cause of acute liver failure (ALF) in the United States, with many patients rapidly progressing to hyperacute liver failure. While hepatocytes are the main target of APAP toxicity, endothelial cells (ECs) are also affected. However, the efficacy of an endothelial-specific biomarker to predict patient outcomes remains unknown.

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Extracellular superoxide dismutase (SOD3) plays an important role in maintaining vascular redox homeostasis by eliminating superoxides. The angiotensin II (AngII) peptide mediates vasoconstriction in part via reactive oxygen species (ROS) but has pathologic effects when elevated in adults. Histone deacetylase 6 (HDAC6) modulates the acetylation of non-histone substrates and is associated with hypertensive disorders.

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Background: Black and Hispanic prostate cancer (PCa) survivors, who face a high burden of comorbid conditions and often engage in low levels of physical activity and healthy eating, remain significantly underrepresented in lifestyle intervention studies.

Purpose: Given the significance of spousal influence, we developed a culturally tailored lifestyle intervention for these survivors and their spouses and assessed its feasibility, acceptability, and impact on behavioral change.

Methods: Survivor-spouse couples were randomly assigned to an intervention group (n = 22), which received 12 health-coaching calls over 6 months, or a usual-care control group (n = 9).

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Oxidative stress caused by reactive oxygen species (ROS) and superoxides is linked to various cancer-related biological events. Extracellular superoxide dismutase (SOD3), an antioxidant enzyme that removes superoxides, contributes to redox homeostasis and has the potential to regulate tumorigenesis. Histone deacetylase 6 (HDAC6), a major HDAC isoform responsible for mediating the deacetylation of non-histone protein substrates, also plays a role in cancer progression.

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During field work on Hon Son Island, we discovered a new species of the genus Cyrtodactylus inferred from genetic and morphological evidence. Phylogenetic analyses based on the mitochondrial gene ND2, delimit Cyrtodactylus borgattaorum sp. nov.

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Background: There is currently no validated tool available for assessing the potential significance of pharmacist interventions in Vietnam.

Aim: This study aimed to translate the CLEO tool from French into Vietnamese, validate the Vietnamese version, and demonstrate its feasibility in daily practice.

Method: The CLEO tool was translated into Vietnamese (CLEO) using a 5-step process by bilingual experts.

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Article Synopsis
  • * Researchers found that the Cat Ba langur has low genetic diversity, high inbreeding rates, and harmful mutations, indicating a significant genetic burden; however, some adaptive potential has been preserved.
  • * Unique genetic variants related to calcium and sodium metabolism were identified, suggesting these adaptations might help the langurs thrive in their specific environment of high calcium and saltwater.
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  • Bilberry (Vaccinium myrtillus L.) is a nutrient-rich wild berry from northern Europe, known for its beneficial anthocyanins, but less is understood about its other quality traits like size and flavor during ripening.
  • The study used metabolomic and proteomic analysis across four ripening stages to uncover regulatory networks involving plant hormones that influence quality traits, showing how different metabolites are linked to fruit development.
  • Key findings include the role of gibberellic, jasmonic, and salicylic acids in unripe fruits, and the importance of abscisic acid and ethylene in ripening, potentially impacting future berry cultivation and applications in food and cosmetics.
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  • The study investigated the biocompatibility of squid ink melanin nanoparticles (NPs) on various human stromal cells and zebrafish embryos, finding they are generally non-toxic and compatible.
  • The NPs did not induce cell aging or affect cell movement in human fibroblasts and stem cells, but they hindered tube formation in endothelial cells at certain concentrations.
  • In zebrafish embryos, melanin NPs were shown to be safe, indicating potential for use in biomedical applications, particularly in contexts involving radiation exposure.
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Background: During the COVID-19 pandemic, health care professionals experienced high levels of depression. However, extant research has not highlighted effective internet-based psychological interventions to improve the mental health in this population during the pandemic. It remains unclear whether self-guided, internet-based cognitive behavioral therapy (iCBT) programs are effective in improving the mental health of health care workers during the COVID-19 pandemic.

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  • A series of 14 conjugates combining 2α,3β,23-triacetyl-madecassic acid and silybin were created and tested for their effects on HepG2 cancer cells.
  • The conjugates were connected at specific positions (C-7 or C-3) and showed greater cytotoxicity than their parent compounds in initial tests.
  • The most effective conjugate, identified as compound 8, significantly impacted other cancer cell lines and induced specific cellular processes like apoptosis and cell cycle arrest, highlighting its unique biological effects compared to madecassic acid alone.
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Background: Understanding co-occurrence patterns and prognostic implications of immune-related adverse events is crucial for immunotherapy management. However, previous studies have been limited by sample size and generalisability. In this study, we leveraged a multi-institutional cohort and a population-level database to investigate co-occurrence patterns of and survival outcomes after multi-organ immune-related adverse events among recipients of immune checkpoint inhibitors.

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Hypertension affects one billion people worldwide and is the most common risk factor for cardiovascular disease, yet a comprehensive picture of its underlying genetic factors is incomplete. Amongst regulators of blood pressure is the renal outer medullary potassium (ROMK) channel. While select ROMK mutants are prone to premature degradation and lead to disease, heterozygous carriers of some of these same alleles are protected from hypertension.

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  • The text refers to a correction made to an article with the DOI 10.3389/fphar.2023.1156655.
  • This correction likely addresses inaccuracies or updates in the original publication.
  • The article is published in a pharmacology journal, suggesting it focuses on a topic related to pharmaceuticals or drug research.
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Erythroid sarcoma (ES) is exceedingly rare in the pediatric population with only a handful of reports of de novo cases, mostly occurring in the central nervous system (CNS) or orbit. It is clinically and pathologically challenging and can masquerade as a nonhematopoietic small round blue cell tumor. Clinical presentation of ES without bone marrow involvement makes diagnosis particularly difficult.

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  • A study examined the risk of new thrombotic events in patients with non-cirrhotic portal vein thrombosis (NCPVT) linked to local factors after stopping anticoagulation therapy.
  • Out of 154 patients assessed, a significant portion had high-risk prothrombotic factors, with new thrombotic events occurring in 17 patients during a median follow-up of 52 months.
  • The results suggest that high-risk factors increase the likelihood of new thrombosis, while continuous anticoagulation treatment may reduce these risks effectively.
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Using a population-level cohort analysis, our study demonstrates that, although rare, autoimmune cutaneous connective tissue diseases (AiCTDs) in the setting of immune checkpoint inhibitors (ICIs) are not associated with a greater risk of mortality and overall approach a statistically significant decrease in mortality when compared with patients treated with ICIs who do not experience cutaneous immune-related adverse events. These findings are significant and highly relevant to dermatologists and oncologists caring for ICI recipients as it adds to the limited information on development of cutaneous AiCTD following ICI administration, for which enhanced understanding is critical to improving the care for this challenging patient population.

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In recent years, organophosphate esters (OPEs) have become one of the most common additives in various consumer products worldwide, therefore the exposure and impact of OPEs on human health are drawing a lot of attention. In this study, three metabolites of OPEs including bis(1,3-dichloro-2-propyl) phosphate (BDCIPP), diphenyl phosphate (DPhP) and diethyl phosphate (DEP) were investigated in first-morning void urine samples taken from a population (age range: 3-76 years old) in Hanoi, Vietnam. The most dominant urinary OPE metabolite was DEP with the geometric mean of specific gravity adjust (SG-adjusted) concentration were 1960 ng mL and detected frequency (DF) of 98%.

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Fifty percent of all acute liver failure (ALF) cases in the United States are due to acetaminophen (APAP) overdose. Assessment of canonical features of liver injury, such as plasma alanine aminotransferase activities are poor predictors of acute liver failure (ALF), suggesting the involvement of additional mechanisms independent of hepatocyte death. Previous work demonstrated a severe overdose of APAP results in impaired regeneration, the induction of senescence by p21, and increased mortality.

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Article Synopsis
  • Gallbladder volvulus (GV) is a rare but serious medical condition in children, especially in boys, leading to acute abdominal pain that requires quick surgical intervention to prevent life-threatening complications.
  • A 5-year-old girl presented with severe abdominal pain and vomiting, initially diagnosed with gallbladder inflammation, but upon further imaging tests, she was accurately diagnosed with GV, which showed classic signs like a "floating gallbladder."
  • The patient underwent a successful laparoscopic cholecystectomy after the correct diagnosis, allowing for a good postoperative recovery, highlighting the importance of timely imaging in avoiding severe outcomes like gallbladder perforation.
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Background: The electronic National Immunization Information System (NIIS) was introduced nationwide in Vietnam in 2017. Health workers were expected to use the NIIS alongside the legacy paper-based system. Starting in 2018, Hanoi and Son La provinces transitioned to paperless reporting.

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