Publications by authors named "Nezar Eltayeb-Elsheikh"
Article Synopsis
- The study aimed to assess the usefulness of DQ-genotyping in screening for celiac disease (CD) among type 1 diabetic (T1D) patients in a Saudi population, focusing on the frequency of DQ-genotypes, associated risks, and cost-effective screening strategies.
- Involved 67 T1D patients with CD and 224 without, analyzing their HLA-DQ genotypes to compare risks of developing CD.
- Results showed a significant correlation between homozygous DQ2.5/DR3-DQ2.5 genotypes and increased risk for CD, while only 4% of patients had no risk genotypes, confirming celiac serology tests
Aims: Type 1 diabetes (T1D) is an autoimmune disease that affects many children worldwide. Genetic factors and environmental triggers play crucial interacting roles in the aetiology. This study aimed to assess the contribution of HLA-DRB1-DQA1-DQB1 alleles, haplotypes, and genotypes to the risk of T1D among Saudis.
View Article and Find Full Text PDFObjectives: It remains unknown what degree of risk is conferred by celiac disease (CD)-predisposing human leukocyte antigen (HLA)-DQ genotypes in Saudi Arabia compared with in Western countries. In this study, we aimed to determine the CD risk gradient associated with the HLA-DQ genotypes and to compare HLA-DQ genotypes between symptomatic patients with CD and screening-identified asymptomatic CD patients.
Methods: We enrolled three groups of subjects, including 46 CD children diagnosed consecutively over the past 10 years, 54 CD children diagnosed during a mass screening of schoolchildren, and 192 healthy controls.
Background/aim: To determine the frequency of celiac disease (CD)-predisposing human leukocyte antigen (HLA)-DQ genotypes in the Saudi population, where the prevalence of CD is 1.5% as recently reported in a mass screening study.
Patients And Methods: In a cross-sectional population-based study, a total of 192 randomly selected healthy school children (97 females, mean age 10.
Genetic and environmental factors play important roles in predisposing an individual to the development of type 1 diabetes (T1D). Several studies have investigated the role of killer cell immunoglobulin-like receptors (KIRs) and their HLA-class I ligands in susceptibility to T1D development, but only some of these studies have demonstrated an association. KIRs and their corresponding HLA class I ligands were investigated in Saudi patients with T1D compared with healthy controls.
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