Publications by authors named "Nevgun Sepin"
Article Synopsis
- Human papillomavirus (HPV) is a leading sexually transmitted virus, and this study investigates the effectiveness of two sampling methods—cotton swabs (CS) versus nylon-flocked swabs (NFS)—for HPV-DNA testing in men with genital warts.
- The research involved 45 men, and results showed that NFS detected significantly more HPV types, including high-risk variants, compared to CS, with NFS identifying 106 HPV types overall versus 84 types for CS.
- The findings suggest that NFS are more reliable for HPV-DNA testing in this demographic, highlighting their superior capability in detecting multiple HPV infections and more high-risk strains, recommending their use over CS for better HPV detection.
Background: Human papillomavirus (HPV) causes a serious socioeconomic burden globally. However, there is currently no consensus on the optimal sampling method for HPVDNA genotyping in circumcised heterosexual men. This study aimed to determine the diagnostic efficacy of 6 different anatomic sampling sites in HPV DNA polymerase chain reaction (PCR) testing of circumcised heterosexual men with genital warts.
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- * Results showed that PCR identified pathogens in 83.1% of cases, while the A.F. Genital System only found them in 18.1%, highlighting the former's superior effectiveness.
- * The A.F. Genital System demonstrated low sensitivity (21.7%) in detecting urethritis pathogens, which raises concerns about its reliability and potential for missed diagnoses in acute urethritis patients.
Purpose: The association between the human papillomavirus (HPV) and anogenital carcinomas is well established. However, despite its anatomic adjacency, the relationship between HPV and urothelial carcinoma of the bladder (UCB) is less clear. Recent meta-analysis and case-control studies demonstrated a significant relationship between the presence of HPV DNA and UCB.
View Article and Find Full Text PDFBackground: The effectiveness of microscopy of Gram-stained smear (GSS) for the detection of male urethral infection is debatable, especially in cases with low inflammation and no visible urethral discharge. This clinical study compared GSS samples collected with the conventional swab method and our new technique, the kissing slide method, together with polymerase chain reaction results to demonstrate the effectiveness of this new method in men with acute urethritis.
Methods: The study included 64 men who presented to the urology outpatient clinic with complaints of acute urethritis between October 2019 and January 2020.
Human papillomavirus (HPV) is the most common pathogen of sexually transmitted disease worldwide. While HPV is responsible for low-grade benign lesions in the anogenital area such as condyloma acuminatum, it is also strongly associated with cervical, anal, vulvar/vaginal, and penile carcinomas. In addition to being an oncogenic virus, HPV causes a substantial socioeconomic burden due to the recurrence of benign lesions, the lack of a definitive treatment option that provides a complete cure, and the high cost of treatment.
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- The study investigates the link between human papillomavirus (HPV) and urothelial carcinoma of the bladder (UCB) through testing urine samples from patients diagnosed with UCB and a control group.
- 69 UCB patients and 69 control patients provided urethral swabs and urine samples, which were analyzed for HPV-DNA using a PCR assay detecting 22 HPV genotypes.
- Results showed that 28.9% of UCB patients tested positive for HPV-DNA compared to 8.7% in the control group, indicating a significant association between HPV infection and UCB, independent of tumor grade.
The aim of this study was to investigate the sensitivity of GSS in the diagnosis of urethritis in patients who present to the outpatient clinic with symptoms of urethritis. Sixty-three male patients who presented to our outpatient clinic with symptoms of urethritis between January and March 2018 were evaluated. Urethral smear samples obtained from patients were evaluated both by GSS examination and by Real-time Multiplex Polymerase Chain Reaction (rt-MPCR) assay.
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